Search PubMed⌕ Search

Biomedical subjects

A D Jorge

Publications and source records attributed to A D Jorge.

At least 19 recordsLinked to original sources
PubMed1993

Steroid receptors and heat-shock proteins in patients with primary biliary cirrhosis.

Primary biliary cirrhosis has a definite female preponderance. Increased estrogen levels have been found in patients with this disease; however no studies indicate the status of sex hormone steroid receptors in primary biliary cirrhosis patients. In this study the occurrence and distribution of estrogen receptors, progesterone receptors and androgen receptors in liver biopsy specimens from patients with primary biliary cirrhosis were examined and compared with these receptors in the normal liver. In addition, three heat-shock proteins associated with steroid receptors (90 kD, 70 kD and 27 kD) were examined. All of the receptor proteins were detected on immunocytochemical study using specific receptor antibodies; monoclonal and polyclonal antibodies were also used to detect the heat-shock proteins. Normal bile duct epithelial cells displayed low-to-moderate amount of estrogen receptors and abundant 90- kD, 70- kD and 27-kD heat-shock protein expression, whereas normal hepatocytes showed moderate estrogen receptor and 90-kD heat-shock protein and high 70-kD heat-shock protein expression. Expression of 70-kD heat-shock protein was due mainly to the constitutive form of this protein (hsc72). In patients with primary biliary cirrhosis, significant increases in estrogen receptor and 90-kD heat-shock protein content were seen in bile duct cells and in hepatocytes. Levels of 27-kD heat-shock protein were also increased in some of the primary biliary cirrhosis biopsy specimens. The expression of progesterone receptor and androgen receptor was very low in normal and primary biliary cirrhosis bile duct cells and hepatocytes.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1991

[Sclerosing treatment of esophageal varices].

The results of esophageal varices treatment in two groups of patients are shown. The first group consists of 351 patients who suffered an hemorrhage and were treated with sclerosing varices during the acute period or in the intervals of bleedings. The second group consists of 90 cirrhotic patients to whom a prophylactic treatment was administered. From 67 patients treated during acute hemorrhage 6 (9%) died due to hemorrhage, 6 (9%) due to hepatic failure and 1 (1.5%) due to sepsis. The 90 cirrhotic patients with prophylactic treatment were divided in 3 groups. In the first group of 30, 15 were sclerosized and 15 did not get treatment. From the second group of 32, 16 got propranolol and 16 no treatment. In the third group of 28, 14 got propranolol and were sclerosized and 14 were not treated. In all three groups with treatment hemorrhage ceased in a statistically significative manner. Surviving was the same in the treated and non-treated groups. Most patients died due to an hepatic failure.

Esophageal and Gastric Varices↗
PubMed1991

Estrogen receptors, progesterone receptors and heat-shock 27-kD protein in liver biopsy specimens from patients with hepatitis B virus infection.

It has been proposed that in the human liver, the estrogen receptor gene may become inappropriately expressed as a consequence of HBV integration, contributing to cell transformation. This study was undertaken to examine estrogen receptor status in patients with hepatitis B virus infection and to analyze the expression of progesterone receptor and of a heat-shock 27,000-D protein (hsp27), both of which are estrogen regulated in estrogen target tissues. Receptor proteins were detected in liver biopsy specimens by immunocytochemistry using antireceptor monoclonal antibodies; a monoclonal antibody was also used to detect hsp27. Estrogen receptor and progesterone receptor were mainly seen in the nuclei of hepatocytes. The presence of hepatitis B virus infection did not always result in elevated estrogen receptor expression, but in general the expression of this receptor protein was higher in hepatitis B virus-positive patients than in patients with the same pathological findings (hepatitis, cirrhosis, hepatocarcinoma) but without hepatitis B virus. This was more clearly seen in the patients with hepatitis. Although estrogen receptor expression was moderate to high in many samples, the expression of the two biochemical markers of estrogen action at postreceptor levels (progesterone receptor and hsp27) was low or absent in most of the liver tissues examined, suggesting that in the liver the interaction of estrogen-estrogen receptor-DNA has characteristics inherent to this tissue.

Adolescent↗
PubMed1989

[Effect of somatostatin and ranitidine in acute hemorrhage of the upper digestive tract].

The effects of Somatostatin and Ranitidine were studied in 46 patients with acute hemorrhages of the upper digestive tract, 23 were medicated with Somatostatin, 12 with acute gastric hemorrhages of medicamental etiology and 11 with ulcers. The doses was 500 micrograms bolus and than infusion of 250 micrograms/h. 23 patients were treated with 300 mg/day I.V. of Ranitidine, 12 had acute gastric hemorrhages also of medicamental etiology and 11 with ulcers. Somatostatin stopped the bleeding in 100% of the patients with hemorrhagic gastritis, meanwhile Ranitidine only in 76%. This is statistically significative (p less than 0.04648). Hemorrhages in patients with ulcers were stopped by Somatostatin in 73% and by Ranitidine in 64%. This is not statistically significative (p = 0.4995). No collateral effects were observed in both groups of patients.

Acute Disease↗
PubMed1985

Primary sclerosing cholangitis.

Primary sclerosing cholangitis was diagnosed in 6 patients (4 men and 2 women), with ages ranging from 33 to 71 years. Four of them had ulcerative colitis, with an evolution from 8 to 21 years, the other two had Crohn's disease with 2 and 3 years of evolution. 66% of the patients had pain in the right upper quadrant; 50% complained of itching, 33% presented with fever, jaundice, weight loss and hepatomegaly and 16% had splenomegaly. 50% of these patients were diagnosed as having Sjörgren's syndrome. Alkaline phosphatase and gamma GT were elevated in 100% of the cases; SGOT and SGPT were slightly elevated in all cases; bilirubin was elevated only in 50% of the cases. Cholelithiasis was found in 2 patients with Crohn's disease and 1 patient with ulcerative colitis. All were subjected to laparoscopy. 2 of them were diagnosed as having persistent chronic hepatitis and the remaining patient had hepatic fibrosis. ERCP revealed alterations in the intrahepatic ducts and there was stenosis of the end of the common bile duct in one of them. The most frequent histological findings were periportal reactions with lymphocytes, plasma cells of macrophages, and periductal fibrosis with obliteration of the canaliculae.

Adult↗
PubMed1985

[Results and prognostic factors in the treatment of chronic active hepatitis with prednisone and azathioprine].

Fifty-two patients with active chronic hepatitis (A.C.H.) were treated with prednisone and azathioprine simultaneously. Seventy-three per cent of the patients were cured. Healing was obtained in 94% of the patients who did not reveal necrotic bridging prior to treatment, while only 43% of the patients who had this sign was cured. Eighty-one per cent of the cases with no A- no B active chronic hepatitis was cured, while only in 66% of patients with B A.C.H. remission was obtained. All the Non A- Non B A.C.H. patients who recovered did so in less than 3 years, while only 40% of the B + A.C.H. patients obtained complete remission in the same period of time. The remaining 60% of the B + A.C.H. group recovered in a period ranging from 3 to 12 years. In the B + A.C.H. group 75% patients of the male sex were cured, while only 33% of the females recovered. Active cirrhosis was seen in 7.6% of cases. All of them were B+. Mortality rate was 3.8 and only the B + group was affected. In conclusion it must be remarked that the presence of necrotic bridging, virus B and female sex were the factors that revealed the worst prognosis as response of A.C.H. to the combined treatment of prednisone and azathioprine.

Adolescent↗
PubMed1984

Peritoneal tuberculosis.

In a total of 8,400 laparoscopies performed over a period of 16 years, 42 cases of tuberculous peritonitis (0.5%) were diagnosed. Free ascites with multiple yellowish-white nodules in the peritoneum, thickening and hyperemia and retraction of the greater omentum were found in 35 cases. Ascites with multiple adhesions in the peritoneum was observed in 4 cases, and peritoneal thickening and adhesions of the viscera without ascites were observed in only 3 cases. Tuberculous peritonitis was found to be associated with genital tuberculosis in 3 women, with hepatic tuberculosis in 2 cases, and with renal and hepatic tuberculosis in 1 case. Laparoscopic diagnosis was confirmed by intralaparoscopic biopsy in all cases.

Adult↗
PubMed1982

Injection sclerotherapy of esophageal varices.

Forty-one patients with hepatic cirrhosis of alcoholic etiology and esophageal varices were subjected to endoscopic sclerotherapy. Four patients were treated during the intervals between hemorrhages; thirty after their first hemorrhage and 7 prophylactically. Propranolol was administered to 5 patients, in doses of 60-80 mg daily. The survival rate for a period of 5 to 16 months was 83%. No complications attributable to the procedure were observed.

Endoscopy↗
PubMed1980

[Transparieto-hepatic cholangiography with Chiba needle].

253 percutaneous transhepatic cholangiographies with Chiba needle were performed. In 83% of the cases the biliary tract could be visualized. In the patients with extrahepatic cholestasis 92% success was achieved, while only 48% success in the cases with intra-hepatic cholestasis. Complications were developed in 3,87% of cases (choleperitoneum 4, cholangitis 2, hemorrhage 2, paralytic ileum 1, hemobilia 2). There was no mortality. Patients with dilated biliary tract should be operated upon in no more than 24 hours following the procedure.

Adolescent↗
PubMed1978

[The effect of chenodesoxycholic acid on cholesterol gallstones (author's transl)].

30 patients with radiolucent gallstones and 2 patients with radioopaque stones recieved chenodesoxycholic acid (CDC). In 12 patients stones were dissolved completely by CDC therapy, in 6 of the patients the size of the stones decreased by 40-70%. Only 1 patient developed severe diarrhea, so therapy had to be stopped. In 5 patients there was a slight and transient increase in SGOT and SGPT, in 2 other patient gammaGT increased; value normalized while treatment was continued. In 23 cases liver biopsies were done before and during treatment: no histological changes could be found in the specimens. 5 of the patients, whose gallstones had been dissolved, received 500 mg CDC/day thereafter, another 5 patients received 500 mg/d every other day. No recurrence of lithiasis was observed in either group. One patient on 500 mg CDC twice a week developed lithiasis after 6 months, another one stopped treatment completely and gallbladder stones reappeared after 8 months. The patients with radioopaque stones did not show any changes during treatment.

Adult↗
PubMed1978

Therapeutic evaluation of chronic aggressive nepatitis and its relation to the Australian antigen.

Twenty-seven patients with chronic aggressive hepatitis were treated with azathioprine and methylprednisolone for a long term ranging from 7 to 92 months. HbsAg was positive in 59% of cases. Of the 27 patients, 12 revealed healing between 7 and 82 months after therapy was started; seven patients revealed histological improvement with an interval in treatment between 12 and 58 months; two of them did not show histologic changes from 37 to 84 months and 6 developed cirrhosis at the 24th and 92nd months after treatment. It was noted that all the negative HbsAg either improved or healed, while the positive HbsAg achieved a favourable evolution in 50% of cases; the rest remained either in an histologically unchanged condition or developed cirrhosis. On considering the healed patients we may confidently state with 95% of certainty that treatment leads to normalization between 9% and 50% for the positive HbsAg patients and between 37% and 92% for the negative HbsAg patients.

Adolescent↗
PubMed1977

[Early detection of colonic and rectal cancer; extensive study of occult blood].

Due to the high frequency and usually late diagnosis of cancer of colon and rectum the "haemoccult test" has been recommended as an easy, quick, and unexpensive method for stool determination of occult blood that will allow us to suspect the existence of these tumors in their early asymptomatic stages. The test was performed in 1437 patients attending the gastroenterology clinic which had no clinical evidence of bleeding, of these, 1150 returned the samples. In 52 (4,6%) the test was positive for occult blood. The studies performed revelated that 4 were upper gastrointestinal ilions, one ileal diverticulum and 40 (3,47%) patients had colonic disease of the latter 19 were diverticular disease, 1 crohnis disease of rectum, 2 adenomatous and 2 villous polips, 1 Hodkgin disease and 7 carcinomas. There were 6 false positive results. The high frequency of positive "haemoccult test" in colonic disease, specially benign and malignant tumors, make this test and appropiate method of this time in the detection for colo-rectal carcinoma.

Adenocarcinoma↗