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Biomedical subjects

A Cordero

Publications and source records attributed to A Cordero.

29 records · Page 2Linked to original sources
PubMed1976

Treatment of skin and soft tissue infections with cefadroxil, a new oral cephalosporin.

Oral cefadroxil in doses of 0-6-1-8 g per day given on twice or three times daily schedules was effective in the treatment of thirty-six patients with infections such as abscesses, carbuncles, cellulitis, furunculosis and impetigo. Staphylococcus aureus strains and beta-haemolytic streptococci, alone or in combination, were cultured from lesions before treatment. In vitro studies with test discs showed that all the organisms were sensitive to cefadroxil, but twenty-three of twenty-nine S aureus strains and one of the seven streptococci strains were resistant to penicillin G. Pre- and post-treatment laboratory tests of renal, hepatic and haematopoietic functions produced no evidence of drug toxicity. The cefadroxil dosage effective in this study is lower than that recommended for currently available oral cephalosporins, which must be given on a four times daily schedule.

Adolescent↗
PubMedDate not supplied

[Utility of beta-blockers in the treatment of chronic heart failure].

Heart failure has become a major public health problem. About 2-3% of people over 65 years suffer from Heart Failure. A huge amount of money is spent every year treating problems connected with this syndrome. In this paper we analyse randomised prospective trials which support the use of beta-blockers in these patients. We also analyse the benefits of this treatment and some special considerations concerning the use of these drugs.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

[New strategies in cardiovascular prevention].

Cardiovascular diseases, especially coronary heart disease, are the leading cause of mortality in Spain and western countries. The prevention of complications is based on a cardiovascular risk stratification that is based on the presence of classical cardiovascular risk factors. There are many scales for cardiovascular risk stratification that classify subjects into low, intermediate or high risk. Despite the fact that the impact and treatment of risk factors are well known, their control remains poor. Obesity, diabetes, and hypertension seems also seem to be increasing trends due to the changes in lifestyles and nutritional habits of our communities. In recent decades some new, or emerging, cardiovascular risk factors have been identified that can improve the stratification of cardiovascular risk: C-reactive protein, homocysteine, and lipoprotein a. The metabolic syndrome is an association of cardiovascular risk factors that cluster in the same subject because they share a physiopathologic link: insulin resistance. Its presence is related to most cardiovascular risk factors, classical or emerging, especially obesity, hypertension, and C-reactive protein. On the other hand, detection of subclinical or incipient atherosclerosis, especially with the measurement of intima-media thickness, offers indirect information closely related to coronary atherosclerosis that improves the stratification of subjects at intermediate risk.

Cardiovascular Diseases↗
PubMedDate not supplied

[Progress in diagnostic and management of cardiac arrhythmias].

The era of catheter ablation for the treatment of arrhythmias began in 1981 when Dr Scheinman performed the first atrioventricular junction ablation using direct current shocks in a patient with drug refractory atrial fibrillation and an uncontrolled ventricular rate. With the progress of radiofrequency catheter ablation, the range of arrhythmias amenable to catheter ablation and the number of patients that could be treated safely by this procedure expanded enormously. Lastly, although still in an evolutionary phase, catheter ablation to eliminate atrial fibrillation has been demostrated in the past years to be feasible and clinically useful. On the other hand, innovations in technology and pharmacology, and better preventive and diagnostic tools, have provided our patients with an important improvement in their prognosis. The new developments in molecular genetics and biology are likely to change the way we approach a cardiac patient in the future. The diseases are now being deciphered at the most basic level, and the information obtained opens new possibilities not only for better therapeutic and diagnostic measures but also for prevention of the disease.

Anti-Arrhythmia Agents↗
PubMedDate not supplied

[Changes in lactate dehydrogenase levels in acute articular rheumatism, chorea minor and the Schönlein-Henoch syndrome in childhood].

Changes in serum LDH in AAR, Sydenham's chorea and purpura rheumatica and their significance were investigated in 103 cases observed at the 1st Paediatrics Clinic, University of Turin. A search was made for relation between such changes and the laboratory parameters in rheumatism. The data showed that blood LDH can be profitably determined in the diseases considered.

Adolescent↗
PubMedDate not supplied

[Changes in fibrinogen values in children with acute articular rheumatism and streptococcal disease].

A study was made of changes in body fluid parameters of rheumatism following treatment with sulphoadenosine-methionine and classic forms of management. Particular attention is drawn to improvement of the serum electrophoretic picture (especially in the case of alpha 2 and gamma-globulins) with respect to untreated control group. Note is also taken of the drug's positive influence on liver function, particularly with regard to lactate hydrogenase, compared with the variations in such parameters in the control group.

Acute Disease↗
PubMedDate not supplied

[Radiofrequency ablation in the treatment of supraventricular tachyarrhythmia. Experience with 500 consecutive patients].

Several reports have demonstrated that radiofrequency catheter ablation provides effective control of a variety of supraventricular tachyarrhythmias. This report details the results of radiofrequency catheter ablation in 500 consecutive patients with a wide variety of supraventricular tachycardia treated at the Instituto Nacional de Cardiología "Ignacio Chaávez". Tachyarrhythmias were associated with the presence of an accessory pathway in 355 patients (71%). The accessory pathways were capable of both anterograde and retrograde conduction in 220 of cases (60%), only retrograde conduction in 146 (40%), dual accessory pathways were present in 11 patients (2.2%) giving a total of 366 accessory pathways. The mechanism of the arrhythmia was AV nodal reentrant tachycardia in 115 patients (23%). Ablation of the reentrant circuit of atrial flutter within the right atrium was attempted in 15 (15%) patients and a primary atrial tachycardia in 3 patients (0.7%). AV node ablation and permanent pacemaker implantation were performed in 11 patients (2%). Radiofrequency catheter ablation was successful in 312 of 355 (87.9%) patients with accessory pathways 312 of 366 (85.2%) pathways with a complication rate of 6/355 (2%) and a recurrence rate of (12.4%). AV nodal reentry was successfully abolished in 110 of 115 patients by selective ablation of the slow pathway in 92/96 (95.8%) patients and the fast pathway in 18/19 (94.7%) patients. The complication rate of this group was 7/115 (6.0%) with a recurrence rate of 16 patients (12%). The reentrant circuit of atrial flutter was ablated successfully in 13 of 15 patients with recurrent atrial flutter in (27%) patients. 2/3 (66%) primary atrial tachycardia were successfully ablated. Complete AV block was achieved in 11 of 11 patients with atrial fibrillation or flutter treated by AV nodal ablation without complications or recurrence. The results of this series of patients demonstrates the safety and efficacy of radiofrequency ablation for the treatment of a wide variety of supraventricular arrhythmias with high rate of success and low risk of complications.

Adolescent↗
PubMedDate not supplied

[Radiofrequency ablation in the treatment of supraventricular arrhythmias in pediatrics. Experience with 203 consecutive patients].

We report the results of radiofrequency catheter ablation in 203 patients under 18 years of age with supraventricular tachyarrhythmias between April 1992 and June 1997. The presence of an accessory pathway caused the tachyarrhythmia in 181 patients (89.1%) with a total of 187 accessory pathways; atrioventricular nodal reentry caused the arrhythmia in 18 patients (8.8%) and atrial flutter in only 4 patients (1.9%). We eliminated the accessory pathway in 171 patients (91.4%), 23 patients showed recurrence of the tachycardia and we had complications in 4 patients (2.1%). The procedure was successful in the treatment of the atrioventricular nodal reentry in the 18 cases, with ablation of the slow pathway in 17 cases and in only one patient of the fast pathway, one patient showed total A-V block, and recurrence of the arrhythmia in 3 cases (16.6%). Finally the procedure was successful in the 4 cases of atrial flutter with one recurrence (25%). In the total of the series, the radiofrequency catheter ablation was successful in 193 patients (95%), with recurrence of the arrhythmia in 27 cases (13.3%) and with complications in only 5 patients (2.6%). Radiofrequency catheter ablation is a safe and effective procedure for the definitive treatment of supraventricular tachyarrhythmias in children.

Adolescent↗