Biomedical subjects

A Coppola

Publications and source records attributed to A Coppola.

130 records · Page 8Linked to original sources

PubMedDate not supplied

[Basophil count of the newborn is not useful in prediction of allergic diseases].

Basophil granulocytes and their mediators are involved in the pathogenesis of allergic inflammation. We evaluated basophil count, blood histamine content, eosinophil count and serum total IgE levels in one hundred-thirteen healthy newborns at birth. 108 children were prospectively studied with a follow-up to 18 months of age for development of topic disorders. No difference was found in newborns with biparental family history of atopy (FHA) in comparison with newborns with monoparental FHA and with newborns without FHA. Children who developed atopic disorders had neonatal basophil count higher than those who did not develop atopic symptoms (p = 0.03). No significant correlation was found between basophil and eosinophil counts (r = 0.013), between basophil count and serum total IgE levels (r = 0.012) and between basophil count and blood histamine content. Positive predictive value and sensitivity of basophil count for allergy up to 18 months of age was respectively only 33% and 27%. Our data indicate that an increased basophil count at birth is not associated with FHA and is not a good predictive marker of atopy.

Age Factors↗

PubMedDate not supplied

Basophil count in neonates is not suitable for atopy predictivity.

Basophil granulocytes and their mediators are involved in the pathogenesis of allergic inflammation. We evaluated basophil count, blood histamine content, eosinophil count and serum total IgE levels in one hundred-thirteen healthy newborns at birth. 102 children were prospectively studied with a follow up to 18 months of age for development of atopic disorders. No difference was found in newborns with biparental family history of atopy (FHA) in comparison with newborns with monoparental FHA and with newborns without FHA. Children who developed atopic disorders had neonatal basophil counts higher than those who did not develop atopic symptoms (p = 0.03). No significant correlation was found between basophil and eosinophil counts (rs = 0.013), between basophil count and serum total IgE levels (rs = 0.012) and between basophil count and blood histamine content. Positive predictive value and sensitivity of basophil count for allergy up to 18 months of age was only 33% and 27%, respectively. Our data indicate that an increased basophil count at birth is not associated with FHA and is not a good predictive marker of atopy.

Basophils↗

PubMedDate not supplied

Platelet and monocyte variables in homocystinuria due to cystathionine-beta-synthase deficiency.

To gain insight into the mechanisms responsible for enhanced thromboxane (TX) A2 biosynthesis in homozygous homocystinuria due to cystathionine-beta-synthase deficiency (CBSD), we measured a series of platelet and monocyte variables in 9 homozygous and 8 obligate heterozygous CBSD patients and evaluated their relationships to thromboxane formation, as reflected by urinary excretion of its major metabolite, 11-dehydro-TXB2 (TXM). Consistent with our previous data, homozygous CBSD patients showed abnormally high TXM excretion (1175 +/- 236 pg/mg creatinine vs. 284 +/- 39 in control subjects; p < 0.001). Significantly higher TXM excretion was also found in obligate heterozygotes (755 +/- 450 pg/mg creatinine; p < 0.05 vs. control subjects). All platelet and monocyte variables fell within the normal range in CBSD patients and none showed a correlation with TXM excretion (p always > 0.05). Our results argue against abnormalities of platelet and monocyte function being responsible for the abnormally high in vivo TXA2 biosynthesis in homocystinuria due to CBSD.

Adolescent↗

PubMedDate not supplied

[Effects of prolonged work on "deep-sea" fishermen: influence of blood cortisol, prolactinemia and urinary catecholamines].

Effects of persistent overwork on the deep-sea fishermen: influence on serum cortisol and prolactin, and on urinary catecholamine levels. Variations in serum prolactin and cortisol levels and in urinary catecholamines levels were studied in fishermen exposed to a persistent overwork period of deep-sea fishing. Results indicate that prolactin was rapidly modified. In fact, the serum prolactin levels already increased on the first day and maximum levels were observed on the fifth day. On the contrary, the physiological rise and fall in the serum levels of cortisol were scarcely influenced on the first day while on the fifth day increased in the morning and fell in the evening in a very significant manner. No significant variation in urinary catecholamine levels was observed at the end of fifth day. These results suggest that, unlike for prolactin, the effects of stress on serum levels of cortisol are complex and, under our conditions, could be due, at least in part, to the duration of the stress and to the functional moment of pituitary-adrenal axis.

Adult↗