Search PubMed⌕ Search

Biomedical subjects

A Coppola

Publications and source records attributed to A Coppola.

At least 91 records · Page 5Linked to original sources
PubMed1990

[Pituitary-testicular evaluation in patients with chronic renal insufficiency in hemodialysis treatment].

Hormone assays were performed in 10 nephropathic men on haemodialysis who revealed reduced libido and importance. In particular, testosterone, 17-beta-estradiol, prolactin, FSH and LH plasma levels were assayed in 8 patients before dialysis and at last, after both long and short interdialytic periods. Below normal testosterone, elevated 17-beta-estradiol, FSH at the upper limits of the range and markedly increased LH levels were noticed; prolactin levels were almost normal. No substantial difference was observed between pre- and post-dialytic hormone levels, after either interdialytic periods. Testosterone, 17 beta-estradiol, prolactin, FSH and LH plasma levels were again assayed in 8 patients (six of the former group + two more) and afterwards a test with HCG was performed. Basal hormone levels agreed with the previous ones; prolactin levels were quite normal. An almost complete absence of response of testosterone and 17-beta-estradiol to HCG was noticed. These results demonstrate a primary hypogonadism responsible for reduced libido and impotence in the patients on haemodialysis investigated.

Adolescent↗
PubMed1990

[Pathogenetic endocrine aspects of primary osteoporosis].

The pathogenetic endocrine aspects of primary osteoporosis are reviewed on the basis of some physiological remarks. Specifically, postmenopausal and senile osteoporosis represent 2 distinct clinical entities. For both, the last event in the pathogenetic chain is in any case the negative skeletal balance, but the starting point and the development of processes present differently.

Aged↗
PubMed1989

Preventive distinction of patients with primary or secondary hypertension by discriminant analysis of chronobiologic parameters estimated on 24-hour blood pressure patterns.

This investigation deals with a statistical probatory that patients with primary (PH) or secondary (SH) hypertension may be correctly diagnosed by a discriminant analysis of the chronobiologic characteristics computed on the 24-hour blood pressure (BP) patterns. The methodology concerning non-invasive 24-h BP monitoring, chronobiologic analysis and the discrimination process is detailed. Substantial dissimilarities were found in the statistical distribution for systolic and diastolic BP rhythmometric parameters (mesor, amplitude and acrophase) by a retrospective assessment of two groups, consisting of 54 patients with PH and 16 patients with SH. The group-related distribution for rhythmometric parameters was found to be significantly different to generate a statistically significant intergroup discriminatory boundary. The discriminant analysis correctly diagnosed patients with PH and SH in a percentage of about 91% and 63%, respectively. The high incidence of success is convincing that the combination of 24-h BP monitoring/chronobiologic analysis/discrimination process cna be a practical tool for confidently selecting patients with a presumable PH or SH.

Adolescent↗
PubMed1989

Circadian rhythmicity of plasma amino acid variations in healthy subjects.

The circadian periodicity of plasma amino acids (AA) was explored using Cosinor analysis. Six healthy subjects eating a standard diet (30 Kcal and 1 g of protein/Kg of body weight) were studied. Plasma samples for AA determination were taken at 07:00, 11:00, 15:00, 17:00, 21:00 and 24:00. The majority of AA showed an increment in the evening samples. This 24-h variability led to a circadian rhythmicity for all AA, except for taurine, threonine, glutamate, alanine, cystine, and total tryptophan. On average, the fluctuation was approximately 15% of the mesor and the acrophase timing was between 17:00 and 22:00.

Adult↗
PubMed1989

[Etiopathogenetic aspects of central diabetes insipidus. Report of a clinical case].

The manifold etiopathogenetic conditions responsible for central diabetes insipidus are minutely examined. On the ground of these introductory remarks, the Authors report a case of diabetes insipidus following from pituitary metastasis in a patient with cancer of the lung. Some relations between diabetes insipidus and cancer are discussed. The uncommon remark of a metastatic lesion in the etiopathogenesis of the central diabetes insipidus and its early display in the patient at issue support this description.

Carcinoma↗
PubMed1988

[Gynecomastia. A clinical review].

In connection with male breasts, an extensive review of gynecomastia is reported. In particular, the manifold physiological and pathological conditions bringing about this breast disorder are examined in detail.

Adolescent↗
PubMed1986

[Acromegaly. Physiopathological aspects and description of a clinical case].

Recent physiopathological studies suggest that hypersecretion of GH in acromegaly is not necessarily the result of a primary alteration to the GH-secreting pituitary cells. Some suggest that an alteration in the hypothalamic control of the hormone secretion may also be involved. After a general introduction, a clinical case of acromegaly is reported.

Acromegaly↗
PubMed1982

Pseudolymphoma with mycosis fungoides manifestations, hyperresponsiveness to diphenylhydantoin, and lymphocyte disregulation.

Three patients receiving diphenylhydantoin (DPH) were seen with a reversible process suggesting mycosis fungoides. Clinical and laboratory manifestations included generalized pruritic exfoliative erythroderma, eosinophilia, lymphadenopathy, hepatosplenomegaly, circulating Sézary cells, epidermal Pautrier's microabscesses on skin biopsy, and moderate liver dysfunction. Studies of the distribution and function of the various lymphocyte subpopulations from these patients showed: (1) an increase in the relative and absolute number of T lymphocytes (85--92%); (2) significant stimulation of lymphocyte-blastic transformation by DPH and low response to pokeweed mitogen stimulation; (3) the impaired ability of T gamma lymphocytes to suppress B-cell differentiation and immunoglobulin production. With only one exception, 15 symptom-free patients on DPH showed none of these abnormalities. The clinical manifestations and immunologic abnormalities of patients with this pseudo mycosis fungoides syndrome remitted three to four weeks after DPH administration was discontinued. The proliferation of T lymphocytes and the inhibition of the function of T gamma-suppressor lymphocytes noted in these patients may be significant to the development of other types of pseudolymphoma and to that of true lymphoma.

Adolescent↗
PubMed1982

Sézary syndrome presenting as a follicular dermatosis.

A patient with erythroderma initially characterized by follicular papular dermatosis was diagnosed clinically and histologically as having probable pityriasis rubra pilaris. In addition the patient had an elevated WBC with absolute lymphocytosis. Ninety percent of the lymphocytes had the features of Sézary cells by light and electron microscopy. He was diagnosed as having Sézary's syndrome despite the noncharacteristic findings in the skin biopsy. This case illustrates that Sézary's syndrome can present initially as a follicular dermatosis.

Humans↗
PubMed1982

Ultrastructure of lymphocytes in a case of pertussis syndrome.

A case of an 11-month-old black male with pertussis syndrome is described. He manifested a lymphocytic leukemoid reaction characterized by marked lymphocytosis and the presence of lymphoblasts in his circulation. A bone marrow examination did not reveal any evidence of acute leukemia. Electron microscopic examination of peripheral blood lymphoid cells revealed the presence of lymphoblasts and immature plasma cells, as well as unusual intramitochondrial and intranuclear bodies. The significance of these structures is discussed.

Cell Nucleus↗
PubMed1982

Study of blood vitamin C in lung and bladder cancer patients before and after treatment with ascorbic acid. A preliminary report.

A systematic study of vitamin C blood levels in patients with cancer and an evaluation of their modifications when the patients were orally treated with daily large doses of ascorbic acid (5g/day) have been carried out. For excluding any interference on intestinal vitamin C absorption, all patients with digestive tract cancer have been excluded. Our first results concern 24 lung cancer and 35 bladder cancer patients, operable or not, of different sex and age. The study has shown hypovitaminosis C subclinic conditions for the greater part of subjects: in fact the average haematic rate of ascorbic acid approaches to lower level of physiologic range, appearing very low particularly for the younger patients. Periodic haematic dosages of vitamin C of unoperable and operated patients treated with large doses of ascorbic acid, have shown a rapid increase of its blood concentration which frequently has been very over 1500 micrograms%, the higher level of normal range. These high vitamin haematic levels, generally constant during the time, appear usefull in increasing the defence reactions of the cancerous patient.

Adenocarcinoma↗