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Biomedical subjects

A Consoli

Publications and source records attributed to A Consoli.

At least 91 records · Page 5Linked to original sources
PubMed1981

[Effect of scheduling of meal times on the circadian rhythm of energy expenditure].

15 obese subjects were studied under different meal-timing schedules in order to see if meal-timing could affect the circadian pattern of energy expenditure. 4 subjects were given one meal (700 Kcal.) a day at h 10 in the morning (for 3 days) or at h 18 in the afternoon (for another 3 days). 4 subjects were given 3 meals (240 Kcal. each) at h 10, h14, h 18 for 3 days. 7 subjects were kept absolutely fasting for 36 hours. O2 consumption and CO2 production were measured minute by minute for 30' every 4 hours by means of a gas-analyser Mijnardht Oxicon II. Urine Samples were taken every 4 hours for urinary nitrogen determination. Energy expenditure was calculated according to Consolation's formula. Cosinor test was used to detect circadian rhythms. A statistically significative circadian rhythm of energy expenditure could be detected in all the protocols. The observed small differences among acrophases and the overlapping of confidence's ellipses allow to conclude that meal-timing doesn't affect the circadian rhythm of energy expenditure and suggest that this rhythm can be considered endogenous.

Adult↗
PubMed1981

[The artificial pancreas in the evaluation of insulin sensitivity in healthy subjects].

24-hours peripheral insulin sensitivity was studied in 5 healthy subjects by mean of artificial pancreas (Biostator), using the glycemic clamp technique (100 mg%). A sharp rise of insulin sensitivity (expressed as glucose required/insulin evoked ratio) was obtained in the morning, confirming our previous data observed by insulin tolerance test, but in a more physiological condition. The subjects appeared well synchronized as documented by statistically significant circadian rhythms in both serum cortisol and body temperature.

Adult↗
PubMed1981

[Treatment of unstable diabetes by continuous subcutaneous infusion of insulin].

In a group of seven brittle diabetic males, hospitalized, two kind of treatment has been compared: conventional insulin therapy (three daily injections) versus continuous subcutaneous insulin infusion. A strike improvement of metabolic control has been reached with the latter procedure. It is concluded that this new type of treatment seems very useful in brittle diabetics. The possible benefit on diabetic complications remains to be investigated.

Adult↗
PubMed1981

[Effects of a "single-meal" low calorie diet on the circadian variation of serum cortisol, insulin and somatotropin and urinary excretion of catecholamines].

Four obese patients were given a single-meal diet for two periods of three days each. Blood samples were drawn every four hours for serum determinations of growthormone, cortisol and insulin. At same times urinary samples for urinary cathecholamines determination were collected. Cortisolemia showed a firm circadian rhythm in both regimens: there was a marked over-lap of the two confidences ellipsis so we could conclude for the independence of cortisol rhythm whith both regimes, but there occurred a significant difference in the acrofases between the two regimens. This could mean that meal-timing can play a major role in syncronizing catecholamines urinary excretion as far as subjects in supine position are concerned. No circadian rhythm was detected either in serum insulin or in HGH values.

Catecholamines↗
PubMed1981

[Modifications of the water balance and urinary excretion of sodium and potassium in obese subjects on a "single-meal" low-calorie diet].

Four obese patients were given a single-meal diet (684 kcal.) for two periods of three days each. Water-loss, according to Peter-Passmore formula, and urinary sodium and potassium excretion were measured at 4-hours intervals. A water-loss greater in the first than in the second and in the third day in both periods and a strong linear correlation between water-loss and sodium urinary excretion were found. Furthermore a circadian rhythm either is sodium or in potassium urinary excretion not modifiable by meal timing with both regiment was detected.

Adult↗
PubMed1981

[Variations in carbohydrate, lipid and protein oxidation evaluated by indirect calorimetry in obese subjects on a "single-meal" low-calorie diet].

Four obese patients were given a single-meal diet (Kcal, 684) for two periods of three days each. CO2 production and 02 consumption were measured every four hours for 30'. At the same times urine samples were collected for nitrogen evaluations. By Consolatio's formulas the amount of carbohydrates, lipids and proteins oxidated in the three days of both periods was calculated. No changes in carbohydrate and lipid oxidation rates were found during the three days with meal at h.10, while a progressive increase in lipid oxidation and a progressive decrease in carbohydrates oxidation could be observed with meal at h. 18. No change with both regimes could be observed in protein oxidation. Furthermore a circadian rhythm of lipid and carbohydrate oxidation with both regimens was observed, while protein oxidation showed a circadian rhythm only with meal at h.10.

Adult↗
PubMed1981

[Nipple discharge].

The Authors examine the various types of breast discharge concentrating in particular on the secretions due to inherent pathology. After having studied origin, they concentrate on the diagnostic significance and the limits of exfoliative cytology and contrast mammography. The Authors conclude by presenting an original protocol of treatment of the afflicted breast illustrating in addition, the various surgical techniques proposed for the cure of the sicknesses of intramammary origin that cause abnormal discharge.

Adult↗
PubMed1979

[Clinical and therapeutic considerations on bochdalek's congenital posterolateral diaphragmatic hernia (author's transl)].

The Authors describe 5 cases of Bochdalek's posterolateral diaphragmatic hernia in terms of their clinical, diagnostic, and therapeutic aspects. They also explain their criteria in the choice of surgical approaches and describe reconstruction methods used in the repair of large hernias. Finally, they propose a special schedule of postoperative management to be used in connection with neonatal surgery, where surgical mortality is still high.

Child, Preschool↗
PubMed1978

[Therapy of pneumogenous respiratory insufficiency. Preliminary physiopathology].

A physiopathological approach to the treatment of chronic pneumogenous respiratory insufficiency is proposed. To this end, disturbances of the ventilatory and alveolocapillary stages of the pulmonary respiratory function are discussed. Particular attention to distribution and diffusion disturbances and the main diseases to which they give rise. A treatment program based on these premises is put forward.

Humans↗
PubMed1978

[Intrathoracic goiters].

Reference is made to the nosographical classification of intrathoracic goitre and the difficulties associated with its diagnosis. Particular attention is devoted to the correct surgical technique required. Surgery is mandatory in mediastinal cases on account of the slow and gradual progression of the swelling and exacerbation of the symptoms, and also because complications may supervene (cancer, intraparenchymal haemorrhage, etc.). The approach routes are discussed, along with the conditions requiring resort to a complementary route--usually median sternotomy--in addition to cervicotomy.

Adult↗
PubMed1976

[Gastric diverticula].

The Authors, on the basis of two recently observed cases of gastric diverticula, emphasize its relative rarity and set out the various aetiopathogenetic theories of the disease. In this connection they point out that, apart from congenital alterations, particular importance may attach to gastric dyskinetic factors. The Authors conclude by discussing the diagnostic difficulties posed by gastric diverticula and setting out the modern possibilities of study and therapy of the disease.

Diverticulum, Stomach↗
PubMedDate not supplied

Insulin requirement of simple and complex carbohydrate foods in type 1 (insulin-dependent) CSII-treated diabetic subjects, obtained by biostator. Correlation with glycaemic index.

The aim of this work was to observe whether different types of carbohydrates might require different insulin doses. Five type 1 CSII-treated diabetic subjects (age 39 +/- 4 years), C-peptide negative and in optimal metabolic control (HbA1c 7.5 +/- 0.2) were selected for the study. They were connected to the Biostator 6 times with an interval of 4-10 days between sessions and fed a meal containing 75 g of carbohydrates of different types: bread, pasta, potatoes, apples, oranges and sucrose. The following net (above basal) insulin requirement for the 30 meals were found (IU - mean + SD): bread 9.15 +/- 1.97; pasta 6.00 +/- 1.37; potatoes 7.05 +/- 2.58; apples 4.54 +/- 1.42; oranges 6.21 +/- 2.62; sucrose 7.83 +/- 2.33. A statistically significant difference was found by ANOVA among insulin requirements for foods (p less than 0.05). Single comparisons between bread and the other foods showed a statistically significant difference only between bread and apple (p less than 0.05). Mean coefficient of variation was 33.9% for the subjects and 30.7% for the meals. A significant correlation was found between Jenkins' glycaemic index and insulin requirement (r = 0.897; p less than 0.001). In conclusion, the high intraindividual variability of insulin requirement does not advice the use of the glycaemic index during optimized insulin therapy.

Adult↗
PubMedDate not supplied

[Esophageal achalasia. Personal experience with 76 patients].

The Authors report their experience on 76 patients managed for oesophageal achalasia from 1973-1997. 65 patients have been surgically treated with Heller miotomy (19 cases) or miotomy with antireflux procedures (46 cases); 11 patients underwent an endoscopic pneumatic dilation. 54 patients, 43 surgically and 11 endoscopically treated, have been followed for a mean length of time of 6 years and 6 months. Complete cure or significant improvement of symptoms have been noted in 86% and 72.7% of patients treated respectively with surgery or pneumatic dilatation. The results have been evaluated according to the recent data from the literature and diagnostic and therapeutic aspects of primitive achalasia are discussed.

Adolescent↗