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Biomedical subjects

A Colombo

Publications and source records attributed to A Colombo.

At least 541 records · Page 30Linked to original sources
PubMedDate not supplied

Pseudotumor cerebri: clinical features and evolution.

Risk factors, neurological, neuroradiological and ophthalmological features of 13 cases of acute pseudotumor cerebri were studied. After a 53-month period of mean follow-up, ophthalmological complications were taken into consideration: one patient (8%) showed unilateral optic atrophy with complete loss of vision, another subject complained of visual field constriction, and a third one of transient horizontal diplopia. Papilledema, which was present in 100% of the patients in the acute phase, persisted in 62%.

Adolescent↗
PubMedDate not supplied

Doxorubicin resistance circumvention by verapamil in B16 melanoma cells.

We present data on the cellular drug pharmacokinetic alterations correlated with the circumvention of doxorubicin resistance by verapamil in a B16 melanoma cell line. An increased drug uptake, a decreased drug efflux and a different intracellular drug distribution appear to be responsible for the enhancement of doxorubicin cytotoxicity induced by treatment with verapamil in drug-resistant cells. However, doxorubicin pharmacokinetics and cytotoxicity were not affected by verapamil in doxorubicin-sensitive melanoma cells.

Animals↗
PubMedDate not supplied

[Risk factors and short-term prognosis in ischemic and hemorrhagic attacks: review of 503 patients admitted to the Neurologic Clinic of Modena].

Cerebrovascular risk factors, characteristics of the lesion (ischaemia or haemorrhage in the carotid or vertebro-basilar area) and mortality in the acute phase were studied in 503 patients admitted for first stroke. Seventy-five per cent of the patients had an ischaemic lesion and 25% a hemorrhagic one. Most of the ischaemic lesions occurred in patients aged 71-80 years, while haemorrhagic strokes hit subjects aged 61-70 years. Hypertension favors haemorrhage and heart disease and the older age favors ischaemia. Coma at onset negatively influences prognosis; mortality is more frequent among older patients, subjects in coma or with haemorrhagic lesions. Twelve per cent of the patients died in the first three weeks post-onset.

Adolescent↗
PubMedDate not supplied

[52 cases of spontaneous cerebral hemorrhage].

The review of a large number of acute hemorrhagic strokes was undertaken to study the relationship between localization and size of lesion demonstrated by CT scan and clinical neurologic grade agreed with the classification of Gillingham. Moreover we could evaluate the prognostic value of clinical grade and of hyperglycemia especially in non-diabetic patients. We have also considered some suggestions on risk factors and on therapeutical treatment according to clinical neurologic grade.

Acute Disease↗
PubMedDate not supplied

[Primary hyperaldosteronism. Diagnostic procedure useful in hospital routine].

Personal experience in the management of three cases of primary hyperaldosteronism, in which a cure was obtained by surgical removal of an adrenocortical adenoma, is was used in the elaboration of a diagnostic procedure requiring hospitalisation for 12 days. During 6 days, the patient is kept on a diet containing 100 mEq Na and K, and blood potassium values are repeatedly determined. Other causes of hypertension are ruled out. On the 6th day, baselines for blood renin and urinary aldosterone are calculated. Next, a hyposodic diet is given for 4 days, and a diuretic is administered on the last of these days, after which renin is determined "in response to stimulation". Lastly, two days of i.v. NaCl loading are followed by the determination of urinary aldosterone "during inhibition". If the picture is positive for hyperaldosteronism, the patient is discharged and followed during treatment with spironolactone, and eventually subjected to renal and adrenal arteriography to determine the site of the adenoma. Division of the procedure into increasingly complex steps enables the examination to be halted at any point when evidence in support of the suspected diagnosis fails to appear. This feature, coupled with the simplicity of the procedures adopted, enables all young subjects admitted for unexplained hypertension to be screened for hyperaldosteronism, with the assurance of obtaining certain diagnosis without an excessively long stay in hospital.

Adenoma↗
PubMedDate not supplied

[Crossed aphasia: considerations on a clinical case].

A right-handed patient with no family history of either neurological disorders or of left-handedness was affected by crossed aphasia due to a focal hemorrhagic lesion in the right hemisphere at the level of the basal ganglia. The CAT-scan revealed the site of the brain change. Our case is uncommon in that the aphasia. Assessed by neuropsychological tests, was associated with impairment of right functions such as visual and spatial cognition. Thus he does not fit the classic description of crossed aphasia, exhibiting instead language disorders similar to those following deep brain lesions. Various hypotheses were considered in attempting to explain the pathogenesis of our neurological data, none of which proved adequate to account for all the reported findings.

Aged↗
PubMedDate not supplied

[Foix-Chavany-Marie syndrome. Case report].

Foix-Chavany-Marie syndrome is characterized by diplegia involving the face, the pharynx, the tongue and the masticatory muscles, with automatic-voluntary dissociation due to vascular damage of both operculi. The prognosis is usually good for life expectancy. The authors describe a 46-year-old man in whom one operculum was destroyed because of a birth trauma, the other one was injured by an ischemic infarct in the territory of the middle cerebral artery. The clinical correlations to the site of the lesions are discussed. They confirm the diagnostic value of CT scan in evaluating this syndrome.

Birth Injuries↗
PubMedDate not supplied

[Licorice-induced myopathy. Report of a new case].

A 64 year-old man, who had been ingesting 20 g of licorice daily for about five months, developed a progressive, diffuse muscle weakness, with myoglobinuria, severe hypokalemia and elevated serum muscle enzymes. Electromyography and muscle biopsy results were consistent with a necrotizing myopathy. Following licorice withdrawal and appropriate electrolyte administration, complete clinical recovery was observed within about ten days. Previous reports of similar cases are reviewed and causative factors of this kind of myopathy are discussed.

Foodborne Diseases↗