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Biomedical subjects

A Cole

Publications and source records attributed to A Cole.

At least 37 records · Page 2Linked to original sources
PubMed2000

Influence of the anagen:telogen ratio on Q-switched Nd:YAG laser hair removal efficacy.

BACKGROUND AND OBJECTIVE: Laser hair removal is believed to affect only anagen hairs. However, proof of this belief in humans is lacking. The objective of this study was to determine the influence of the anagen: telogen ratio on the results of Q-switched Nd:YAG laser hair removal. STUDY DESIGN/MATERIALS AND METHODS: Fifteen subjects had four test sites delineated in one body area. The test sites were chosen by trimming the hair and evaluating the area in 2 weeks. At that time, the anagen hairs were at least twice as long as the nongrowing telogen hairs and, therefore, could be differentiated and counted. Two sites with a low anagen number and two with a high number were chosen for comparison. All sites were then treated with a Q-switched Nd:YAG laser. Follow-up examination was in 1 month. RESULTS: Test sites with a low anagen number demonstrated a low level of hair loss compared with those sites with a high anagen number. A significantly higher percentage of hair loss was noted when comparing the anagen-only with total hair loss. In addition, lasing plus shaving demonstrated more hair loss than lasing alone. These findings indicated that anagen hairs were clearly affected, but the immediate clinical effect on telogen hairs was minimal. CONCLUSION: Q-switched Nd:YAG laser treatment of anagen hairs results in a rapid switch to telogen and a subsequent clinically obvious shedding of the hair shaft. This process causes a greater percentage hair loss at sites with high anagen number. Telogen hairs demonstrate no such effect and remain in their pretreatment phase after lasing.

Adult↗
PubMed2000

Analysis of the results of the C-Fit uncemented total hip arthroplasty in young patients with hydroxyapatite or porous coating of components.

Young patients at 2 separate centers received a C-Fit uncemented arthroplasty, with randomization to porous or hydroxyapatite coating. No difference in survival could be found between components that were porous or hydroxyapatite coated, with 27.5% being revised within 8 years, mainly for aseptic loosening. Acetabular augmentation screws or offset acetabular liners similarly did not affect outcome. Two of the offset liners had spun within the metal acetabular liners, with early failure. Some of the survivors showed poor clinical scores, but there was no correlation between clinical score and radiographic evidence of loosening. These results are comparable to the poorest reported survival figures in the literature for uncemented prostheses. Prosthesis coating could not be shown to affect component survival for this prosthesis.

Age Factors↗
PubMed2000

Metastatic prostate cancer (with prostate-specific antigen of 9996) presenting as obstructive jaundice.

A 78-year-old man admitted with clinical jaundice and pelvic pain had a total bilirubin level of 6.56 mg/dL, an alkaline phosphatase level of 855 U/L, and a prostate specific antigen (PSA) level of 9996 ng/mL. A computed tomogram demonstrated marked retroperitoneal, peripancreatic, periceliac, and periaortic lymphadenopathy. A bone scan revealed increased radiolabeled technetium uptake in the pelvis, vertebral column, parietooccipital region, ribs, and appendiceal skeleton. A biopsy of one pelvic lesion revealed metastatic prostate cancer. This man's obstructive jaundice and bone pain had a dramatic response to treatment with a gonadotropin-releasing hormone analog (leupro lide) and antiandrogen (bicalutamide). All bone pair and clinical signs of jaundice disappeared in 1 week His total bilirubin decreased to 0.84 mg/dL by 2 weeks His PSA values reflected this clinical response, decreasing to 4022 ng/mL in 1 week, 2680 ng/dL after 2 weeks and 1028 ng/mL after 1 month of the above therapy.

Aged↗
PubMed2000

In vivo measurement of colonic butyrate metabolism in patients with quiescent ulcerative colitis.

BACKGROUND: Butyrate, a short chain fatty acid produced by bacterial fermentation, is a major fuel source for the colonocyte. In vitro work has shown that ulcerative colitis may be characterised by a metabolic defect in colonocyte butyrate oxidation. AIMS: To investigate the rate of metabolism of rectally administered butyrate in patients with quiescent colitis. METHODS: [1-(13)C]-butyrate enemas were administered to 11 patients with long standing quiescent ulcerative colitis and to 10 control patients. The rate of production of (13)CO(2) in exhaled breath over four hours was measured by isotope ratio mass spectrometry combined with indirect calorimetry in order to measure CO(2) production. This allowed calculation of the patients' resting energy expenditure and respiratory quotient. RESULTS: Over a four hour period, 325 (SEM 21) micromol (13)CO(2) was recovered in breath samples from the colitis group compared with 322 (17) micromol from the control group (NS). The respiratory quotient of the colitic group was significantly lower than that of the control group. CONCLUSION: There was no difference in the rate of metabolism of butyrate between the two groups. It is unlikely that there is a primary metabolic defect of butyrate metabolism in patients with quiescent ulcerative colitis.

Adult↗
PubMed1998

Complementary therapies as a means of developing the scope of professional nursing practice.

The development of the extended role in nursing has been seen by some as primarily a means for nurses taking on tasks that have traditionally been the work of junior doctors. Others object to this view and ascribe to the 'new nursing' perspective of Salvage. She sees the extended role as moving towards increasing autonomy and operating in a professional rather than a bureaucratic occupational model. This view militates against the development of nurses as mini-doctors. This paper discusses the controversy surrounding the development of the extended role, focusing particularly on the use of complementary therapies as a legitimate component of the 'new nurses' role.

Complementary Therapies↗
PubMed1997

Guidelines for preventing thromboembolism.

Clinicians, units and hospitals in the UK should develop written policies for thromboembolic prophylaxis. Deep-vein thrombosis is both life-threatening and costly. The use of prophylaxis should be included in clinical audit and plans for patient care. The implementation of research-based and agreed guidelines can reduce the incidence of postoperative deep-vein thrombosis.

Humans↗