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Biomedical subjects

A Chaoui

Publications and source records attributed to A Chaoui.

At least 37 records · Page 2Linked to original sources
PubMed1993

[Ovarian pregnancy. Four cases with review of the literature].

The authors report four cases of ovarian pregnancies operated in Central Maternity of Rabat (Pr Chaoui) during a period from 1979 to 1989. In the light of literature data, they have tried to trace out the particularities of this form of extra-uterine pregnancy. Clinical symptomatology of ovarian pregnancy very often remains similar to that of tubary GEU as well as the data of complementary exams with the exception sometimes of coelioscopy. The treatment, because of diagnostic delay, is annexectomy in all cases. But it is desirable to carry out a conservative treatment in the form of partial ovariectomy. Only pathological anatomy can give the diagnosis a sense of certainty.

Adult↗
PubMed1992

[Hydatidiform mole and its complicated development].

The authors report a series of 260 cases of trophoblastic disease, followed up over a period of 18 years. Supervision was based on clinical findings, biological development, radiology and ultrasound. The outcome was favourable in 80% of cases with 2.7% requiring prophylactic hysterectomy for classifical hydatiform mole. In the other cases (20%) the following was the way the disease developed: 12 cases of persistent trophoblastic activity, 13 cases of invasive mole, 24 cases of choriocarcinoma. Initially the treatment was with chemotherapy and surgery was used as an extra treatment in 14% of cases, which gave encouraging results. The authors regret three deaths in this series following choriocarcinoma. Two of these were after chemotherapy as a sole treatment and one after treatment with chemotherapy and surgery.

Adolescent↗
PubMed1992

[Malignant non-Hodgkin's lymphoma of primary mammary localization. Two cases].

The authors report two cases of non-hodgkinian malignant lymphoma (NHML) of primitive mammary localization. Surveying the data of world literature, they have tried to trace the main characteristics of this breast cancer. The NHML are met at all ages, of female predominance and whose clinical aspect is summarized in two great tables: a module radiologically benign, isolated, quite limited, or a tumor of inflammatory aspect. Anatomopathological exam and the extension check-up constitute a fundamental step to establish the diagnosis, to confirm the initial localization and evaluate the prognosis which depends on two main factors: anatomical stage and histological type. Chimiotherapy is indicated initially, often related to a conservative surgery (tumorectomy), rarely to a radiotherapy.

Adult↗
PubMed1992

[Hypertrophic tuberculosis of the cervix. Three cases].

Tuberculosis of the cervix of the uterus is a rare form of genital tuberculosis. The epidemiology does not have any particular specific feature; but the macroscopic appearance gives a first impression of a cancer. Only by carrying out a biopsy of the cervix, followed by study of the histology can the problem be solved so that longterm anti-tuberculous treatment can be started. There is rarely any need for surgery, that only in cases resistant to medical treatment. The authors report three cases of tuberculosis of uterine cervix, found in the university clinic of obstetrics and gynaecology I (Professor Chaoui) during the years 1986-90. The incidence of this condition is 8.5% of genital tuberculosis. The outlook is good with full healing if the treatment is carried out properly.

Adult↗
PubMed1989

Pharmacological activity, blood and tissue levels of indomethacin after single oral administration of two long-acting forms in the rat.

The duration of pharmacological action in the rat (carrageenin edema inhibition) of a long-acting indomethacin form (Dolcidium PL) was compared to that of a reference long-acting indomethacin form after a single oral dose (3 mg/kg) considered as the ED50 value and compatible with clinical use. Kinetic comparison of both forms was achieved in the blood and at the level of the inflammatory site. There was an identical bioavailability, but the rate of indomethacin release from the test preparation was significantly slower than that of the reference form. Greater pharmacological potency and significantly longer duration of action were also demonstrated for the former, indicating that this novel formulation exhibited better sustained release characteristics than the reference form, and thus exerted an optimal pharmacological effect (over 24 hr). Since there is a high degree of correlation of clinical efficacy with potency in the rat foot edema test, better effectiveness of Dolcidium PL should be expected in man. The reduction in peak plasma level of indomethacin should improve its tolerability as well.

Administration, Oral↗
PubMed1987

A study of the effect of decimal and centesimal dilutions of arsenic on the retention and mobilization of arsenic in the rat.

Having developed a pharmacokinetic method for studying the fate of orally administered arsenious anhydride by a radioactive tracer method, the influence of Hahnemannian dilutions of arsenicum album on the elimination and retention of this toxin in the rat was then investigated. The effects of centesimal (cH) and decimal (dH) dilutions were studied. All the dilutions studied were found to be active. The strongest effects were observed after the administration of dilutions corresponding to a concentration of 10(-14) (14dH and 7cH). Overall, the decimal dilutions augmented the elimination of arsenic more than the centesimals. The observed results were submitted to mathematical analysis. A mathematical model, which confirms that Hahnemannian dilutions have biological effects which are a direct function of the degree of dilution, was developed.

Administration, Oral↗
PubMed1985

[Multiple cancers. Apropos of a quadruple cancer].

A woman of 48 years of age presented over a period of twelve years with, successively, a cancer of the rectum, a cancer of the breast, cancer of the scalp and finally of the endometrium without metastases. Her general condition stayed good. We have looked into the nosological, statistical, pathogenic and prognostic features of multiple cancers. It does seem that the hormone state may be the trigger for this polycancerous condition (hyperoestrogenaemia). This was linked to an alimentary factor (obesity) and to a family history of a predisposition to cancer, as our patient was the tissue of a blood-related marriage and a member of a family where the incidence of cancer was 40%. Multiple cancers are 2.42% of all cancers but are mainly double or triple cancers. There are only 20 cases of quadruple cancers in the literature. One can divide these into: Cancers with a short interval between each appearance of simultaneous appearances, which usually occur at an advanced age, due to simple chance and often with a bad prognosis. Cancers that occur at longer intervals in younger people, which are rarer and show a family predisposition or endogenous factors. Their prognosis is as a whole better.

Adenocarcinoma↗
PubMed1984

Preliminary note: effect of microtubule inhibitors with acrylophenone structure on Triton WR 1339 induced hyperlipidemia in rats.

Acrylophenone derivatives having in vitro antimicrotubular activity very similar to that of Colchicine were tested on Triton WR 1339 induced hyperlipidemia in rats. By inducing a disorganization of the microtubular system these compounds decreased the movement of very low density lipoproteins (VLDL) to the extracellular space and consequently decreased hypertriglyceridemia. On the other hand, contrary to Colchicine, these derivatives decreased cholesterolemia more significantly and this could be explained by a second action mechanism.

Acrylates↗
PubMedDate not supplied

MRI isolation of infected renal cyst in autosomal dominant polycystic kidney disease.

The use of gadolinium-enhanced magnetic resonance (MR) to isolate an infected renal cyst in the setting of autosomal dominant polycystic kidney disease (ADPKD) has not been previously described. A case in which T1- and T2-weighted and gadolinium-enhanced MR images were used to identify a single purulent cyst in a patient with ADPKD is herein presented. We suggest that gadolinium-enhanced MR be considered useful in the evaluation of ADPKD patients with suspected infected cyst.

Anti-Bacterial Agents↗