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Biomedical subjects

A Cerillo

Publications and source records attributed to A Cerillo.

At least 37 records · Page 2Linked to original sources

[The role of inflammatory infiltrate as a prognostic criterion in cerebral metastases. Preliminary results].

Data concerning a preliminary study on the prognostic significance of inflammatory infiltration in cerebral metastases are reported. Seventeen cases of operated cerebral metastases have been studied to investigate their histotype and grade of necrosis, stromal reaction, and inflammatory infiltration. Finally, the results obtained are discussed in relation to the postoperative survival rate of the patients.

Brain↗

Antithrombotic effect of indobufen in an experimental model of arterio-arterial microanastomosis in the rat.

Using an end-to-side microanastomosis of the left common carotid into the right common carotid of rats, implementing a potentially thrombogenic situation, we have investigated the possible antithrombotic effect of indobufen, a new antiplatelet drug. In eight of 15 untreated rats the anastomosis was totally obstructed by a single thrombus growing from the anastomotic wall. Indobufen treatment prevented thrombus formation completely in 14 of 15 rats (p less than 0.02). In treated animals indobufen also produced a statistically significant reduction of ADP-induced platelet aggregation relative to basal values. Platelet count were not influenced by drug treatment. Our experimental results suggest the potential usefulness of indobufen as an antithrombotic agent.

Anastomosis, Surgical↗

Transient occlusion of intracranial blood vessels. Presentation of one clinical and preliminary considerations.

The authors suggest that some cerebral ischaemic lesions depend upon a transient obstruction of intracranial blood vessels (particularly the trunk and the branches of the middle cerebral artery). This explains (as in the patient described here) the cases in which an ischaemic lesion does not correspond with the vascular lesions found on arteriography and/or at autopsy. Furthermore the authors indicate the importance of blood flow in the spontaneous relief of obstruction which is favoured by an undamaged vascular bed. Consequently they recommend, if possible, early surgical treatment of the carotid lesions, in order to reduce the risk of emboli and to improve cerebral blood flow in general.

Adult↗

[Supratentorial arachnoidal cysts].

The AA., after having examined the various hypothesis reported in literature about the etiopathogenesis and the contrasting anatomical and pathological data concerning the arachnoid supratentorial cysts, point out the remarkable frequency of they malformative and above-all post-traumatic genesis. On the formation mechanism of this last type, they agree upon the supposition expressed by Taveras and Ransohoff in 1953. The AA., therefore, after having analysed the principal morphological and topographical aspects, pay attention to the present diagnostic possibilities, above all in radiological range, where the TAC represents, by this time, the examination of election compared with traditional assurances with means of contrast. It follows the analysis of the personal casuistry, consisting in 6 arachnoid supratentorial cysts, two of which clearly post-traumatic and two, very probably, of malformative genesis (for the coexistence of data in favour of both suppositions). The AA. draw these conclusions: the CT Scan is the only diagnostic means which permits an exact pre-operating diagnosis on the nature of the lesion; the surgical and, above all, anatomo-pathological reports assume an essential rule for an exact etiopathogenetic interpretation of the lesion examined.

Adolescent↗

Intracerebral haemorrhage: an attempt at statistical assessment for operability.

A series of 88 patients, who underwent operation for intracranial haemorrhage, is reported. The outcomes are assessed in order to evaluate the operability in relation to the patient's age, the type of onset, the site of haemorrhage, the conscious level, the interval between accident and operation, cardiovascular disease and the dysmetabolic values. A numerical value has been assigned to each factor considered; than the correspondence between these values and the importance of each factor in relation to the clinical state has been analysed. The authors finally point out that their study, although it has a merely indicative significance, agrees sufficiently with the clinical results, as to give a useful pattern for a statistical approach to the question of intracerebral haemorrhage, offering in the meantime hopeful aids to diagnosis.

Age Factors↗