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Biomedical subjects

A Cappello

Publications and source records attributed to A Cappello.

At least 37 records · Page 2Linked to original sources
PubMed1998

Skin movement artefact assessment and compensation in the estimation of knee-joint kinematics.

In three dimensional (3-D) human movement analysis using close-range photogrammetry, surface marker clusters deform and rigidly move relative to the underlying bone. This introduces an important artefact (skin movement artefact) which propagates to bone position and orientation and joint kinematics estimates. This occurs to the extent that those joint attitude components that undergo small variations result in totally unreliable values. This paper presents an experimental and analytical procedure, to be included in a subject-specific movement analysis protocol, which allows for the assessment of skin movement artefacts and, based on this knowledge, for their compensation. The effectiveness of this procedure was verified with reference to knee-joint kinematics and to the artefacts caused by the hip movements on markers located on the thigh surface. Quantitative validation was achieved through experimental paradigms whereby prior reliable information on the target joint kinematics was available. When position and orientation of bones were determined during the execution of a motor task, using a least-squares optimal estimator, but the rigid artefactual marker cluster movement was not dealt with, then knee joint translations and rotations were affected by root mean square errors (r.m.s.) up to 14 mm and 6 degrees, respectively. When the rigid artefactual movement was also compensated for, then r.m.s errors were reduced to less than 4 mm and 3 degrees, respectively. In addition, errors originally strongly correlated with hip rotations, after compensation, lost this correlation.

Adult↗
PubMed1998

Optimal CT scanning plan for long-bone 3-D reconstruction.

Digital computed tomographic (CT) data are widely used in three-dimensional (3-D) reconstruction of bone geometry and density features for 3-D) modeling purposes. During in vivo CT data acquisition the number of scans must be limited in order to protect patients from the risks related to X-ray absorption. Aim of this work is to automatically define, given a finite number of CT slices, the scanning plan which returns the optimal 3-D) reconstruction of a bone segment from in vivo acquired CT images. An optimization algorithm based on a Discard-Insert-Exchange technique has been developed. In the proposed method the optimal scanning sequence is searched by minimizing the overall reconstruction error of a two-dimensional (2-D) prescanning image: an anterior-posterior (AP) X-ray projection of the bone segment. This approach has been validated in vitro on three different femurs. The 3-D reconstruction errors obtained through the optimization of the scanning plan on the 2-D) prescanning images and on the corresponding 3-D data sets have been compared. Two-dimensional and 3-D data sets have been reconstructed by linear interpolation along the longitudinal axis. Results show that direct 3-D optimization yields root mean square reconstruction errors which are only 4%-7% lower than the 2-D-optimized plan, thus proving that 2-D-optimization provides a good suboptimal scanning plan for 3-D reconstruction. Further on, 3-D reconstruction errors given by the optimized scanning plan and a standard radiological protocol for long bones have been compared. Results show that the optimized plan yields 20%-50% lower 3-D reconstruction errors.

Algorithms↗
PubMed1998

Model-based dialysis adequacy prediction by continuous dialysate urea monitoring.

A modeling approach for on-line estimation of urea kinetics from continuous measurement of urea concentration in the effluent dialysate stream (DUN) is presented. On-line identification of urea kinetics response parameters is used to predict and update dialysis adequacy during the treatment. Dialysis adequacy can be quantified in several ways, but its strict dependence on final urea concentration is a major fact. For this reason, a good predictive skill on the time course of DUN may enable better performances in the control of dialysis outcome by treatment parameters adjustment. A post-filter enzymatic sensor performs continuous measurement of DUN on patients undergoing standard haemodialysis. To get an early prediction of the end dialysis urea level, the solution of a variable volume double-pool (VVDP) model is used, whose parameters are identified at each time on the basis of the past DUN history Unlike the variable volume single-pool (VVSP) model, this enables a prompt and accurate estimation of the final DUN. In fact, after 75 min the estimates always differ by less than 10% from the values measured by the sensor at the end of the treatment. Moreover, values predicted by the model in the last hour always lie within 1% of measured final values. Real-time knowledge of an analytic expression for whole DUN time course also enables the accurate prediction of total removed urea, with no need of cumbersome dialysate collection techniques.

Aged↗
PubMed1997

Sonographic anatomy of the supraspinatus tendon and adjacent structures.

OBJECTIVE: To depict the detailed sonographic pattern of the normal supraspinatus tendon and adjacent structures. Pathologic findings in these structures. Pathologic findings in these structures are well described, but knowledge of their sonographic anatomy is relatively limited. DESIGN: A new position for sonography of the shoulder was adopted that permits good stretching and a large field of view of the supraspinatus tendon. The right shoulders of 12 healthy adult volunteers and of a 10-year-old boy were imaged. Frozen-frame images of ten standard sections were obtained, anatomic details were sought, and a sonographic normal pattern was reconstructed. RESULTS AND CONCLUSIONS: The study allowed sonographic description of new details, including the presence of two distinct tendons of the supraspinatus. Such a reference normal pattern may be helpful in clinical practice for separating the various components and recognizing artifacts or other possible causes of a misdiagnosis.

Adolescent↗
PubMed1997

Surface-marker cluster design criteria for 3-D bone movement reconstruction.

When three-dimensional (3-D) human or animal movement is recorded using a photogrammetric system, bone-embedded frame positions and orientations are estimated from reconstructed surface marker trajectories using either nonoptimal or optimal algorithms. The effectiveness of these mathematical procedures in accommodating for both photogrammetric errors and skin movement artifacts depends on the number of markers associated with a given bone as well as on the size and shape characteristics of the relevant cluster. One objective of this paper deals with the identification of marker-cluster design criteria aimed at the minimization of error propagation from marker coordinates to bone-embedded frame position and orientation. Findings allow for the quantitative estimation of these errors for any given cluster configuration and suggest the following main design criteria. A cluster made up of four markers represents a good practical compromise. Planar clusters are acceptable, provided in quasi-isotropic distribution. The root mean square distance of the markers from their centroid should be greater than ten times the standard deviation of the marker position error. The second objective of this paper deals with the identification of the optimal cluster position and orientation on the limb aimed at the minimization of error propagation to anatomical landmark laboratory coordinates. Cluster position should be selected to minimize skin movement artifacts. The longest principal axis of the marker distribution should be oriented toward the relevant anatomical landmark position.

Animals↗
PubMed1997

Application of stereophotogrammetry to total body three-dimensional analysis of human tremor.

This work aims at verifying the possibility of investigating joint rotations, with amplitude and frequency ranges typical of pathological human tremor, using commercially available stereophotogrammetric systems together with signal processing techniques. A rotating disk is used as a mechanical tremor simulator to test the ability of the system to track known marker trajectories both in a large and a small calibrated volume. The performances of standard discrete Fourier transform (DFT) and autoregressive techniques are also evaluated and compared in the signal spectrum estimation. Results obtained from a pathological test subject and their dependence on the processing techniques adopted are also presented. The use of stereophotogrammetry and of the proposed signal spectrum estimation technique allow to quantify both frequency and amplitude content of three-dimensional (3-D) rotations of many human joints simultaneously and therefore to isolate the contribution of each joint to the whole body tremor.

Aged↗
PubMed1997

[Echography of the shoulder with the patient supine in the diagnosis of rotator cuff rupture].

We report a new method for shoulder sonography (US): the patient lies supine and his/her arm is positioned so as to optimize tendon depiction. The supraspinatus tendon, which is the most frequently involved structure in rotator cuff tears, is studied with the patient's arm dropped, elbow extended and forearm prone. Our series consisted of 49 surgical patients (arthroscopy in 16 and open surgery in 33 patients): US sensitivity in tear depiction was 84.8%, specificity 100% and accuracy 89.8%. Medium-small tears appeared as transonic areas within tendon substance and/or tendon focal thinning. Large tears appeared as: (a) missed or markedly thinned rotator cuff, with deltoid muscle approximation to the humeral head surface, (b) plenty of fluid collected around bulky tear margins. The US images of 36 patients were then reviewed and the details discussed. A new sign was observed in medium-small tears, that is a sharp hyperechoic band encircling the humeral cartilage (the compass sign). In conclusion, we believe that US performed with the patient in supine recumbency is easier to perform and provides a bigger field of view of the supraspinatus tendon; it also permits to keep stretched rotator cuff, with consequent image quality improvement.

Adult↗
PubMed1996

Optimization and smoothing techniques in movement analysis.

This paper deals with accurate estimation of the degrees of freedom (DOF) of a body segment, starting from the trajectories of clusters of markers acquired with a suitable measurement system. The most commonly employed estimation procedures involve two sequential steps, a trajectory smoothing algorithm and a DOF reconstruction routine. Three optimized smoothing and reconstruction schemes are described, analyzed and tested and their performances are compared with each other and with those of a more traditional technique which contains no optimization criteria. All three schemes include an iterative, weighted-least-squares DOF reconstruction routine and a self-tuning, zero-phase-shift, 4th-order Butterworth filter. Both routines are extensively described and validated on the basis of numerically-simulated marker trajectories. Test results, analyzed on a statistical basis, show that the use of an optimization routine provides a visible improvement in DOF reconstruction. This performance has also been confirmed using stereophotogrammetric data collected on a subject wearing an external fracture fixation device which provides reference values for the bone DOF. Angular DOF estimated applying the optimized method to skin technical clusters are much closer to the reference values than the non-optimized values. Smoothing of data further improves the reconstruction accuracy while a far less crucial role is played by the order in which smoothing and reconstruction routines are applied.

Algorithms↗
PubMed1996

Mechanical validation of whole bone composite femur models.

Composite synthetic models of the human femur have recently become commercially available as substitutes for cadaveric specimens. Their quick diffusion was justified by the advantages they offer as a substitute for real femurs. The present investigation concentrated on an extensive experimental validation of the mechanical behaviour of the whole bone composite model, compared to human fresh-frozen and dried-rehydrated specimens for different loading conditions. First, the viscoelastic behaviour of the models was investigated under simulated single leg stance loading, showing that the little time dependent phenomena observed tend to extinguish within a few minutes of the load application. The behaviour under axial loading was then studied by comparing the vertical displacement of the head as well as the axial strains, by application of a parametric descriptive model of the strain distribution. Finally, a four point bending test and a torsional test were performed to characterize the whole bone stiffness of the femur. In all these tests, the composite femurs were shown to fall well within the range for cadaveric specimens, with no significant differences being detected between the synthetic femurs and the two groups of cadaveric femurs. Moreover, the interfemur variability for the composite femurs was 20-200 times lower than that for the cadaveric specimens, thus allowing smaller differences to be characterized as significant using the same simple size, if the composite femurs are employed.

Biomechanical Phenomena↗
PubMed1996

A minimal parametric model of the femur to describe axial elastic strain in response to loads.

Evaluating the state of stress/strain for a given geometry and load in femurs can be done both experimentally, measuring strain at a limited number of locations, and theoretically with finite element models. Another approach is to describe the state of strain with a few synthetic indices. For this purpose the reverse elastic problem (i.e. bone parameters are estimated given the strain distribution and loads) needs to be solved as opposed to the finite element direct problem. Such reverse models can be then used: (1) to describe simply the strain distribution by means of few synthetic indices; (2) to explain the state of strain; and (3) to predict the strain distribution under different loading conditions. Various linear models, characterized by two to five bone related parameters, were tested on (1) 12 femurs, (2) a finite element model, and (3) data taken from the literature, for a total of 43 loading cases. Three and four-parameter models were able to fit the experimental strain distributions with mean squared residuals smaller than 5% of the strain range. The consistency of the model was proved by the repeatability of the parameters estimate for identical femurs. Furthermore, the bone-related coefficients were able to detect the stiffening effect of the implantation of an uncemented stem. Finally, the model can be used for predictive purposes if the parameter estimates are used with different loading conditions.

Biomechanical Phenomena↗
PubMed1995

Analytic solution of the Variable-Volume Double-Pool urea kinetics model applied to parameter estimation in hemodialysis.

An analytic solution of the Variable-Volume Double-Pool urea kinetics model and its application to the estimation of clinically relevant parameters of the patient-machine system, are presented. These include the urea distribution volume and generation rate and the mean dialyzer clearance. The estimation of these parameters is based on the assumption of constant values for the diffusion coefficient between the two pools and the intra-extracellular volume ratio. Results obtained by computer simulations show that the effect of a +/- 50% variation of these parameters influences the estimates less than standard measurement errors. Starting from these results, four methods to in vivo estimate the urea distribution volume and generation rate from blood samples are compared. Two methods are based on the analytic solution of the double-pool model using seven samples (reference method) or three samples (new clinical method). The remaining methods are based on urea mass-balance and are largely used in the clinical practice. These last techniques differ from each other for the blood sample taken at the end of the treatment or 30 min later. The results obtained from hemofiltration sessions show that the urea generation rate is accurately estimated by all methods. The total distribution volume is still accurately estimated by the new clinical method while it is systematically underestimated by the urea mass-balance when the blood sample at the end of dialysis is used. Instead, a high overcompensation results using the blood sample taken 30 min after the end of dialysis. Finally, the new clinical method also provides reliable estimates for the dialyzer clearance starting from only three blood samples all taken during dialysis.

Algorithms↗
PubMed1995

Sensitivity analysis for estimating urea kinetics parameters during hemodialysis.

In this paper a time-varying volume, double-pool urea kinetics model is considered and a sensitivity analysis is carried out to determine those patient parameters that have greater influence on the time course of blood urea nitrogen concentration (BUN) during and between dialysis treatment. The model parameters include the urea generation rate, the initial distribution volume of the urea, the ratio between intracellular and extracellular volumes, and the mass transfer coefficient between the two pools. The analysis demonstrates that BUN is highly sensitive to the urea generation rate and total distribution volume whereas it is influenced by the remaining parameters to a much lesser extent. In addition, the location of the absolute maxima of BUN sensitivity functions suggests the rational placement of a reduced number of blood samples that may still allow sufficiently accurate estimates for the parameters of clinical interest, such as the urea generation rate, total distribution volume, and the ratio between intracellular and extracellular volumes. This conclusion has been confirmed by simulation studies where parameter estimation has been performed with a varying number of observation points.

Blood Urea Nitrogen↗
PubMed1995

Two new algorithms for tracking arterial parameters in nonstationary noise conditions.

Two new algorithms with reduced sensitivity to the changing environment are applied to tracking arterial circulation parameters. They are variants of the Least-Squares (LS) algorithm with Variable Forgetting factor (LSVF), and of the Constant Forgetting factor-Covariance Modification (CFCM) LS algorithm, devised to overcome their main practical deficiencies related to noise level sensitivity and the high number of design variables, respectively. To this end, adaptive mechanisms are incorporated to estimate observation noise variance in LSVF and the rate of change for the different parameters in CFCM. Specific computer simulation experiments are presented to compare their effectiveness with the original counterparts and to provide guidelines for their optimal tuning at different noise levels. Moreover, algorithm performance degradation, consequent on changes in the noise level compared to that assumed during the tuning phase, is analyzed. In particular, it is shown that, when the noise level changes with respect to the tuning value, the new LSVF algorithm is much more robust than the original one, whose performance degrades rapidly. The new CFCM algorithm is characterized by a reduced number of design variables with respect to its original counterpart. Nevertheless, it can be preferred only when low noise signals are used for estimation.

Algorithms↗
PubMed1995

Influence of flow pattern on the parameter estimates of a simple breathing mechanics model.

The first-order model of breathing mechanics is widely used in clinical practice to assess the viscoelastic properties of the respiratory system. Although simple, this model takes the predominant features of the pressure-flow relationship into account but gives highly systematic residuals between measured and model-predicted variables. To achieve a better fit of the entire data set, an approach hypothesizing deterministic time-variations of model parameters, summarized by information-weighted histograms was recently proposed by Bates and Lauzon. The present study uses flow and pressure data measured in intensive care patients to evaluate the real potential of this approach in clinical practice. Information-weighted histograms of the model parameters, estimated by an on-line identification algorithm, were first constructed by taking into account the parameter percentage standard deviations. Then, the influence of the respiratory flow pattern on the calculated histograms was evaluated by the Kolmogorov-Smirnov statistical test. The results show that the method gives good reproducibility under stable experimental conditions. In addition, for a given airflow waveform, an increase in respiratory frequency shifts the histograms representing time-varying viscous properties strongly versus lower values, whereas it shifts the histograms representing time-varying elastic properties slightly versus higher values. On the other hand, the same histograms were highly dependent on the airflow waveform, especially for the viscous properties. Even in a limited experimental work, in all the conditions considered, the method provides results which agree well with the physiological knowledge of nonlinear and multicompartment behavior of respiratory mechanics.

Algorithms↗
PubMed1995

On-line estimation and prediction of urea kinetics during hemodialysis: a simulation approach.

A new method for the on-line estimation of urea kinetic parameters from blood urea concentration (BUN) continuously measured during a dialysis session is proposed. The method, based on the variable-volume double-pool model, is evaluated through a simulation approach in order to easily consider a large set of well-controlled test conditions. The model is characterized by six parameters, knowledge of which enables early prediction of the end dialysis urea concentration and the dose of dialysis. The sensitivity of the model predicted BUN with respect to the parameters was first analyzed to investigate which can be reliably estimated from blood urea measurements taken at a suitable rate. This analysis showed that the model predicted BUN is highly sensitive to the initial blood urea concentration and to the dialyzer clearance, normalized with respect to the total initial distribution volume, while it is scarcely influenced by the normalized ultrafiltration and urea generation rates. The new on-line estimation technique keeps these two last parameters constant and takes advantage of an original analytic solution of the second order urea kinetics. The results of the estimation process on realistic simulated data showed that the proposed method provides early and reliable estimates of the normalized clearance and of the end dialysis concentration. The transcellular mass transfer coefficient and the intra-extra cellular volume ratio can also be estimated, although with less accuracy. Moreover, it was shown that the use of the single-pool model, instead of the double-pool one, provides systematic errors on the estimates.

Algorithms↗
PubMed1994

Comparative evaluation of different methods to estimate urea distribution volume and generation rate.

Eight methods to estimate urea distribution volume and generation rate from blood urea samples measured in dialysis patients are reviewed. An analytical solution has been provided for a double-pool variable volume kinetic model to allow for faster and more accurate simulation and identification. The reliable parameter estimates provided by the double-pool kinetic model starting from seven samples, were assumed as references for the estimates obtained by the remaining methods. These include three kinetic models and four methods based on urea mass-balance. In particular, the estimation techniques differ in the number of compartments where urea is assumed distributed (double- and single-pool) or in the number of blood urea samples. Among the methods based on mass-balance, two techniques neglecting the weight loss or the urea generation during dialysis, were also analysed. The results obtained during hemofiltration sessions using three samples, usually available in clinical practice at the beginning and at the end of dialysis, demonstrate that a new method based on double-pool kinetics provides, on average, the most reliable estimates. Moreover, methods belonging to a single pool view and including both weight loss and urea generation during dialysis seem to underestimate by 1 divided by 2 liters the urea distribution volume. However, neglecting the weight loss or the urea generation can overcompensate this error, resulting in a significant overestimation of the distribution volume. Finally, it has been experimentally proved that the single-pool kinetic methods overestimate the urea production rate, while techniques based on mass balance provide more reliable values.

Adult↗