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Biomedical subjects

A Bremerich

Publications and source records attributed to A Bremerich.

At least 37 records · Page 2Linked to original sources
PubMed1994

Influence of fetal brain grafts on axotomized retinal ganglion cells.

The neurotrophic activity of fetal brain grafts next to the proximal stump of the transected optic nerve of adult rats was investigated. Axotomy (n = 25) reduced the original retinal ganglion cell population by 90% and the mean neuron size by one-third within 30 days. No increase in number or size of the surviving neurons could be found in any group receiving an embryonic brain graft (E16; spinal cord: n = 16, cerebral cortex: n = 16, tectum: n = 15, thalamus: n = 17) at the site of optic nerve transection, despite good survival of transplants. Although no positive effect on axotomized retinal ganglion cells could be found after transplantation of embryonic central nervous system structures, the same experimental model of the optic nerve seems to be valuable for further investigations of degeneration of traumatized retinal ganglion cells.

Animals↗
PubMed1994

[Reconstruction of the facial skull using implant retained prostheses].

Reconstructive surgery does not always provide for sufficient functional, cosmetic und esthetic results of bone defects, loss of soft tissues and sense organs. 57 patients were treated by the "Bochum study group for oro-facial rehabilitation" from 1990 to 1992 using implant-retained prostheses. The advantages of the "Snap-Button-System" used for retention are presented.

Ear, External↗
PubMed1993

SF-assemblin, the structural protein of the 2-nm filaments from striated microtubule associated fibers of algal flagellar roots, forms a segmented coiled coil.

The microtubule associated system I fibers of the basal apparatus of the flagellate green alga Spermatozopsis similis are noncontractile and display a 28-nm periodicity. Paracrystals with similar periodicities are formed in vitro by SF-assemblin, which is the major protein component of system I fibers. We have determined the amino acid sequence of SF-assemblin and show that it contains two structural domains. The NH2-terminal 31 residues form a nonhelical domain rich in proline. The rod domain of 253 residues is alpha-helical and seems to form a segmented coiled coil with a 29-residue repeat pattern based on four heptads followed by a skip residue. The distinct cluster of acidic residues at the COOH-terminal end of the motifs (periodicity about 4 nm) may be related to tubulin binding of SF-assemblin and/or its self assembly. A similar structure has been predicted from cDNA cloning of beta-giardin, a protein of the complex microtubular apparatus of the sucking disc in the protozoan flagellate Giardia lamblia. Although the rod domains of SF-assemblin and beta-giardin share only 20% sequence identity, they have exactly the same length and display 42% sequence similarity. These results predict that system I fibers and related microtubule associated structures arise from molecules able to form a special segmented coiled coil which can pack into 2-nm filaments. Such molecules seem subject to a strong evolutionary drift in sequence but not in sequence principles and length. This conservation of molecular architecture may have important implications for microtubule binding.

Amino Acid Sequence↗
PubMed1992

[Importance of diagnosis in facial pain].

The diagnosis and treatment of facial pain remains a great challenge for oral and maxillofacial surgeons. By taking an exact anamnesis--especially a pain anamnesis--and by starting specific examinations the patient can quickly be recommended to a qualified therapist. The pain syndromes are classified according to the IASP (International Association for the Study of Pain). The pain syndromes the maxillofacial surgeon is most frequently confronted with--idiopathic trigeminal neuralgia, atypical facial pain and the temporomandibular joint--are described. The necessity of a multidisciplinary examination is emphasized and the different diagnostic investigations are illustrated, particularly in the case of myo-arthropathy. Beside the analysis of temporomandibular joint dysfunction, a radiologic examination is performed. In some cases the advise of a neurologist, ophthalmologist or otolaryngologist may be indicated.

Adult↗
PubMed1992

[Treatment concept of facial pain].

The therapy of chronic facial pain still poses an important challenge. A therapeutical scheme in four steps has been developed. This scheme enables modification of the pain therapy depending on localisation, intensity and former treatment. It consists of the following steps: 1. Transcutaneous electrical nerve stimulation. 2. Medication 3. Extracranial glycerol blocking of the trigeminal nerve 4. Neurosurgical treatment with thermocoagulation, chemical glycerol-rhizotomy and microsurgical decompression. The different therapeutical steps have no influence on each other.

Antipsychotic Agents↗
PubMed1992

[Peri-orbital surgical approaches].

After having made a definitive diagnosis in patients with orbito-frontal pathology, the choice of incision is an important factor to achieve good intra-operative exposure of the region, as well as to obtain a good functional and aesthetic result. In the majority of cases we prefer to utilize the incisions commonly used for blepharoplasty, especially the transconjunctival approach popularized by Tessier. Other more classic accesses such as the superolateral, infra-orbital and intra-oral incisions, are reserved for treatment of cases of orbitomalar (communition) fractures. We feel there are limited indications for use of incisions through the eyebrows with medial extensions for exposure of isolated lesions of the medial orbital wall, orbital roof, and the anterior wall of the frontal sinus. However they may become very useful as the primary incisions in the treatment of open fractures of the orbital region. The bicoronal incision, a classical approach in neurosurgery, is also being used by us in cases of tumors and complicated middle face fractures which appear to extend to the orbito-frontobasal region in 40% of our patients. In addition it provides excellent access for post-traumatic reconstruction of orbito-frontal bone defects and impacted fractures. A combination of different incisions: bicoronal, peri-orbital and intra-oral, may be indicated for the correction of syndromal anomalies such as Treacher-Collins, for treatment of complicated facial fractures, or for pure aesthetic surgery procedures, such as the "mask-lift" introduced by Tessier.

Humans↗
PubMed1992

[Complications of orbito-frontobasal fractures].

Complications of fronto-basal trauma can, as a function of their severity, be divided into three classes: life-threatening situations, functional complications and cosmetic defects or facial deformities. They find their origin in the type of trauma, the extent of the lesions of bone and soft tissues, as well as in their timely management and quality of treatment. The etiology of the most common complications and their significance are covered with accent on inadequate primary treatment, insufficient repair of dural lesions, inadequate drainage, unstable osteosynthesis, insufficient treatment of scalp- and frontal defects, and finally the lack of antibiotic prophylaxis. The major complications of frontobasal trauma such as chronic cerebral spinal fluid fistulae and pneumocephalus are reviewed. Attention is also given to the importance of adequate drainage in cases of chronic ethmoidofrontal sinusitis, and on the treatment of osteomyelitis and sinus cysts. The therapeutic possibilities in patients with tissue deficits, i.e. reconstruction of frontal skull defects using autologous hip and rib material, as well as split calvarial bone grafts is discussed.

Adult↗
PubMed1992

[The treatment of neuralgiform facial pains with the combined therapy of transcutaneous electric nerve stimulation (TENS) and the iontophoresis of nonsteroidal antiphlogistics].

In a prospective study, 46 patients suffering from facial pain were treated by transcutaneous electrical nerve stimulation (TENS). In case of insufficient pain relief the combined use of TENS and iontophoresis of non-steroidal antiphlogistics was employed. Benzydamine was applied to the anode and diclofenac to the cathode instead of the contact gel, reducing average pain intensity to a marked 18%, compared to 81% to 63% by TENS only. Furthermore, the consumption of analgetics declined considerably with combined therapy. Severe side effects could not be registered. Therefore, this new combined therapy must be considered to be an alternative treatment before using systemic medication.

Adult↗
PubMed1991

The innervation of the trapezius muscle in connection with radical neck-dissection. An anatomical study.

The accessory nerve, the cervical plexus, the sternocleidomastoid and trapezius muscles and neighbouring structures were examined in 47 corpses. Considerable inter- as well as intra-individual differences could be found both in the course and shape of the accessory nerve and in the participation of the cervical plexus in the innervation of the trapezius muscle. The great variation in the manifestation of the shoulder-arm-syndrome in patients after radical neck-dissection can thus be explained. Finally a new method of restoring the innervation of the trapezius muscle is proposed.

Accessory Nerve↗
PubMed1991

Mycobacterium leprae renders Schwann cells and mononuclear phagocytes susceptible or resistant to killer cells.

Acquired resistance to Mycobacterium leprae, the etiologic agent of leprosy, crucially depends on cellular immune mechanisms. In addition to interleukin-mediated helper functions, killer mechanisms seem to be involved. This study addresses the question of how M. leprae render mononuclear phagocytes and Schwann cells, its natural targets, susceptible or resistant to killer cells. Killer activities were stimulated in peripheral blood mononuclear cells from healthy individuals by incubation with mycobacteria plus interleukin-2. These cells lysed Schwann cells and mononuclear phagocytes which had been pulsed with dead M. leprae, while unpulsed targets remained virtually unaffected. Importantly, targets infected with viable M. leprae were not lysed; furthermore, infection with viable M. leprae as well as gamma interferon stimulation or heat shock caused resistance in otherwise susceptible targets which had been pulsed with dead M. leprae. Thus, M. leprae markedly influenced the effect of killer cells on Schwann cells and mononuclear phagocytes.

Cells, Cultured↗
PubMed1991

[Possibilities of trigeminal somatosensory evoked potentials in diagnosing neuralgiform facial pain].

The aim of this study was to analyse the possibilities of trigeminal somatosensory evoked potentials (TSEP) as an objective diagnostic tool for the classification of pain sensations of the 5th cranial nerve. 43 patients suffering from trigeminal neuralgia, atypical facial pain and cancer pain were investigated. Pain sensations of patients correlated with changes in the somatosensory evoked response by presenting an increase in latency periods. Specific pathological peaks could not be found, and thus it must be concluded that TSEP changes should be interpreted only in the light of the clinical symptoms.

Adolescent↗
PubMed1991

[Perineural application of glycerol and phenol-glycerol. Histomorphologic-morphometric study].

In a long-term study the effect of glycerol and phenol-glycerol on rats mandibular nerve was analysed. The substances were applicated perineurally. Nerves treated with glycerol did not show any severe pathological changes. Only the number of desintegrations of myelin seemed to be more pronounced. This, however, was a transitary effect. On the contrary, nerves treated with phenol-glycerol showed the familiar picture of degeneration and regeneration. According to our results it can be stated that the perineural application of glycerol has no toxic and destructive effect on the nerve. Therefore, the perineural glycerol blocking will not cause severe side-effects and the method can be recommended in the therapy of chronic facial pain.

Animals↗
PubMed1991

Somato-sensory evoked potentials in facial pain diagnosis.

This study analyses the possibilities of somato-sensory evoked potentials following trigeminal stimulation in order to classify pain sensations provoked by the trigeminal nerve. 43 patients suffering from trigeminal neuralgia, atypical facial pain and from pain due to carcinoma were investigated. Pain sensations correlated with the responses of the evoked potentials--usually with increased latencies. However, it was not possible to point out specific correlative pathological peaks for individual diseases. Therefore, the judgement of TSEP alterations requires knowledge of each patient's clinical symptoms.

Adult↗