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Biomedical subjects

A Bradlow

Publications and source records attributed to A Bradlow.

26 records · Page 2Linked to original sources
PubMed1986

Dupuytren's contracture and alcohol.

Reported alcohol consumption was quantified and scored by a validated questionnaire administered by an interviewer to 64 patients (10 female) with Dupuytren's contracture (DC) before hand surgery and to 89 controls (44 female) admitted for other hand or foot surgery. Serum urate (SUA), gamma-glutamyl transferase (GGT), and mean red cell volume (MCV) were measured on admission. Thirteen of 54 men with DC reported current daily alcohol intake of 40 g or more compared with one of 45 male controls (p = 0.0001). Two of 10 women with DC (but none of 44 controls) admitted consuming at least 40 g alcohol daily (p = 0.03). MCV was higher in men (but not women) with DC than in controls (p less than 0.0005). Current alcohol consumption score of patients with DC correlated with SUA (r = 0.308, p less than 0.05), MCV (r = 0.44, p less than 0.01), and GGT (r = 0.54, p much less than 0.001) on admission. DC among men is strongly associated with heavy drinking, reflected both in self reporting and haematological data.

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PubMed1985

Comparison of reconstructive orthopaedic surgery in patients with seropositive and seronegative rheumatoid arthritis.

The longitudinal orthopaedic history of 107 unselected patients with rheumatoid arthritis undergoing reconstructive surgery was studied to define the relationship between serology and surgery. Using strict criteria 85 patients were seropositive and 22 seronegative. Age, disease duration, number of reconstructive orthopaedic operations, and second-line or corticosteroid drug treatment were similar in seropositive and seronegative patients. Users of steroids and/or second-line drugs had a similar number of operations to non-users. However, patients undergoing only hip or knee surgery used steroids more often in the pre-operative disease than those only having other operations (p less than 0.05). This may reflect more-aggressive disease or the direct effect of steroids. The expected proportions of seropositive and seronegative patients together with their similar surgical and treatment patterns do not suggest that they have different diseases.

Adrenal Cortex Hormones↗
PubMed1985

Alcohol consumption in arthritic patients: clinical and laboratory studies.

In popular belief patients with chronic arthritis take alcohol for its analgesic effect. To test this we studied by validated questionnaire the past and present alcohol consumption of 103 patients with primary osteoarthritis of the hip (OA), 95 patients with rheumatoid arthritis (RA), and 90 orthopaedic non-arthritic controls. OA men were most likely and RA men least likely to have been heavy drinkers at any time of their lives. Mean red corpuscular volume (MCV), gamma-glutamyltransferase (GGT), and serum uric acid (SUA) levels did not correlate with reported alcohol consumption. Two of 93 OA femoral heads examined had avascular change; both were from heavy drinkers. The abstemiousness of RA men compared with their OA counterparts was due to a striking increase in joint pain after drinking alcohol (p = 0.004), fear of adverse drug reactions with alcohol, and a widespread belief not expressed by OA men that 'alcohol and arthritis do not mix'.

Alcohol Drinking↗
PubMed1984

Cutaneous vasculitis and immune complexes in severe bronchiectasis.

Four patients with severe bronchiectasis (chronic bronchial suppuration) are described who developed cutaneous lesions associated with exacerbations of their respiratory disease. The skin abnormalities consisted of purpuric lesions in three patients and an erythematous vasculitis in one. Circulating immune complexes were present in all patients and in three skin biopsy specimens showed deposition of C3, IgG, and IgA in dermal blood vessels. Haemophilus influenzae had been isolated from the sputum of all four patients and in two patients was present at the time the cutaneous lesions appeared. It is suggested that local immune complex deposition was responsible for the skin lesions which occurred during acute exacerbations of bronchiectasis.

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PubMed1983

Reiter's syndrome in a 73-year-old man with bronchiectasis.

We report the case of what we believe to be the oldest person to develop Reiter's Syndrome. There was no evidence of preceding gastro-intestinal or genito-urinary infection but the patient had post-tuberculous bronchiectasis and the role that this might have played is examined.

Age Factors↗
PubMed1982

Group G streptococcal arthritis.

Six cases of Lancefield Group G streptococcocal arthritis are described. Two cases had pre-existing chronic arthritis (one rheumatoid) with infection of a joint prosthesis. Three cases had neoplastic disease before or at the same time as septic arthritis. Skin reactions, including cellulitis and scarlatiniform rash were prominent in five cases. One patient may have acquired a Group G streptococcus from her dog. Five cases responded well to penicillin and the sixth who was allergic to that drug was cured by erythromycin. This unusual cause of septic arthritis is being recognized more frequently in the United Kingdom.

Aged↗