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Biomedical subjects

A Borkowski

Publications and source records attributed to A Borkowski.

At least 109 records · Page 6Linked to original sources

Simultaneous repair of post-irradiation vesicovaginal and rectovaginal fistulas.

A simultaneous repair of radiation-induced vesicovaginal and rectovaginal fistulas is suggested. Creation of a diverting colostomy must be the preliminary procedure. Both fistulas are closed simultaneously several months later. The vesicovaginal fistula is closed with a rotated flap from the apex of the bladder and is reinforced additionally with omentopexy. The rectovaginal fistula is closed by pulling the descending colon through the rectal stump with its mucosa stripped off. The operation was performed with good results on a 42-year-old patient with grade II cervical carcinoma in whom fistulas developed after combined treatment by radiotherapy and an operation.

Colostomy↗

Supracystic urine diversion in patients with bladder carcinoma treated by cystectomy preceded by "short radiotherapy" (2000 R).

The authors assessed the results of supracystic urine diversion in 50 patients treated by cystectomy for bladder carcinoma who had "short radiotherapy" (2000 R) before the operation. It was found that preoperative radiotherapy caused no difficulties during subsequent cystectomy and the observed postoperative complications should be related rather to the surgical technique. It seems that indications to urine diversion by the method of Goodwin or Coffey should be considered with greater caution. In patients past the age of 65 years and those with more advanced neoplasms (T-3, T-4) bilateral ureterocutaneostomy should be performed more frequently for suprapubic urine diversion.

Age Factors↗

Spinal cord damage as a complication of renal artery embolization in patients with renal carcinoma.

The authors report three cases of complications of renal artery embolization in patients with renal carcinoma. In two cases renal artery embolization was followed by paraparesis with loss of sphincter control. In these cases nephrectomy was performed on the side of the neoplasm and neurological disturbances disappeared after pharmacological treatment and rehabilitation. The third patient was not treated surgically. Embolization was followed by development of spinal cord damage at the level Th12. The patient died of neoplastic cachexia and cardiorespiratory failure.

Aged↗

Uretero-ureterostomy, transuretero-ureterostomy.

The authors describe various possibilities of using uretero-ureterostomy in cases of healthy bladder an in cases of supracystic urinary diversion. The history and the technique of the operation are described. Attention is called to the direction of anastomosis in cases of ureters differing in the width of their lumen. Clinical observations of 21 cases of uretero-ureterostomy are reported. In 17 cases transuretero-uretero-cutaneostomy was done. Stenosis of the recipient ureter did not develop in any of these cases. The main complication in transuretero-ureterostomy was stenosis of the foramen of ureterocutaneostomy. For avoiding this complication of transuretero-ureterocutaneostomy only wide-lumen ureters should be anastomosed to the skin.

Adult↗

Encapsulated urinary extravasation (urinoma) as a late complication of ureterolithotomy and pyelolithotomy.

The authors report three cases of encapsulated urinary extravasation as a late complication of ureterolithotomy and pyelolithotomy. Surgical treatment saved the kidney in two cases, in the third case nephrectomy had to be done. The pathological mechanism, diagnostic methods and treatment of this complication are discussed in light of the observed cases and a survey of the pertinent literature.

Adult↗

The human chorionic gonadotropin-like substance in the plasma of normal nonpregnant subjects is not modulated by the gonadotropin-releasing hormone.

To determine whether the hCG-like substance found in the plasma of normal nonpregnant subjects is secreted and regulated like a pituitary gonadotropic hormone or prohormone, we measured its concentration before and 60 min after the acute iv injection of 500 microgram Gonadotropin-releasing hormone (GnRH). The study was performed in 12 normal young men. The hCG-like substance was purified from the other plasma proteins by 2 successive diethylaminoethyl-Sephadex A-50 chromatographies and by gel filtration on Sephadex G-100. Its concentration was measured by a specific RIA, corrected for losses and for possible contamination with human LH (hLH). The median basal concentration in plasma was 19 pg/ml (mean, 41; range less than 5 to 169), and there was no correlation with corresponding hLH concentrations. After the injection of GnRH, the median, mean, and range of concentrations remained constant, whereas the mean hLH concentration increased over 8-fold. This indicates that no significant amounts of the hCG-like substance are acutely releasable from the pituitary gland and that its plasma concentrations are not modulated by GnRH in a fashion similar to hLH. It also constitutes an argument for an extrapituitary origin of the plasma hCG-like substances in normal men.

Adult↗

Renal arterial embolization in cases of renal neoplasms. Own experiences.

Observations of 17 embolizations of the renal artery carried out in cases of renal neoplasms are reported. In the light of intraoperative observations the optimal timing of the operation after embolization was established to be 48-72 hours. Attention is called to the possibility of complications in the form of spinal cord damage after renal arterial embolization.

Adult↗

Regeneration of the ureter and the renal pelvis from transversely transected and anastomosed strip of the ureteral wall. II. Clinical.

Proved experimentally in dogs, the principles of regeneration of the ureter and renal pelvis from transected and anastomosed strips of the ureteral wall were carried out in man in difficult secondary operations. Indications for repair of ureteral avulsions and secondary strictures of the pyeloureteral junction as well as difficult ureteral anastomoses are discussed. Regeneration of the partial loss of the urinary tract walls versus utilization of free graft patches are considered.

Adult↗

[3 experimental contributions to the regeneration of the ureter].

In this paper three experimental series were described in which on dogs the regeneration of the ureter from a longitudinal stripe of its wall was investigated on several conditions. The variations concerned permanently lacking or beginning at different moments after operation urinary flow, immobilisation of the margins of the stripe by sutures, splinting by means of ureteral catheter, suturing of the stripe with one side of the mucous membrane on the serosa of the large intestine, transverse cutting of the stripe with following uniting of the stumps, applications of prednisone and immuran for pre- and aftertreatment. The results were tested radiologically, autoptically and histologically. In their majority they were good and may partly be used clinically.

Animals↗

Human chorionic gonadotropin in the plasma of normal, nonpregnant subjects.

To determine whether ectopic secretion of a protein hormone can occur normally, we studied plasma from normal, nonpregnant subjects for the presence of a placental hormone, human chorionic gonadotropin. We extracted and purified this hormone from other plasma proteins. We identified the hormone in the final residue on the basis of its dose-response curves in a specific radioimmunoassay and calculated the plasma concentration after correction for losses. Because this assay is sensitive to concentrations as low as 2 pg per milliliter, human chorionic gonadotropin could be detected in the plasma of 12 of 16 blood donors; the median concentration was 19 pg per milliliter (range, less than 2 to 361). This immunologic human chorionic gonadotropin was further characterized from a pool of normal plasma by gel filtration on Sephadex G-100 and was found to be identical to the standard form of the hormone. The concentration in this pool from 13 normal men was 18 pg per milliliter. The source of this ectopic hormone production is unknown, but may be normal, rapidly proliferating nonmalignant cells.

Adult↗