Biomedical subjects
Publications and source records attributed to A Bogdan.
Decomposition of nifedipine in Adalat tabl. and Cordafen drops and nitrendipine in Nitrendipine tabl. preparations under influence of UV radiation operation and temperature of 50 degrees C was tested. Chromatographic methods of TLC and HPCL and spectrophotometry were used for evaluation of the decomposition processes.
Melatonin is a hormone secreted mainly by the pineal gland but also by the retina. It is synthesized from tryptophan and its characteristic circadian rhythm is ruled by light through the control of two limiting enzymic activities N-acetyl-transferase and hydroxyindole-O-methyl-transferase. In man--as in all studied species--its maximum plasma concentration is at night. Therefore it is considered as a signal transducing information on solar light within the organism thus providing the temporal framework upon which metabolic pathways are organized. Since its circulating levels decrease with ageing the question arises as to the origin and/or the consequences of this decrease, as well as the possible beneficial effects which could result from its administration in ageing humans.