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Biomedical subjects

A Bogdan

Publications and source records attributed to A Bogdan.

At least 91 records · Page 5Linked to original sources
PubMed1976

Anti-adrenocortical activity of SKF 12185 and SKF 252 A.

The synthesis of aldosterone and 18-hydroxycorticosterone from triated corticosterone by sheep adrenal homogenate have been studied in presence of increasing concentrations of SKF 12185, a product already known as an inhibitor of cortisol synthesis. An approximately 98% inhibition of the synthesis of both steroids occurred with only 2 x 10(-4) M of the drug. In contrast, incubation of a structurally closely related compound (SKF 252 A) under the same experimental conditions resulted in an only 52% inhibition with higher concentrations (2 x 10(-3) M). These findings could explain the marked aldosterone fall that occurs in SKF 12185 treated subjects and supports the therapeutic use of this product in treatment of hyperaldosteronism.

18-Hydroxycorticosterone↗
PubMed1975

[Circadian variations of 17-hydroxycorticosteroids and of tetrahydro-11-deoxycortisol in the healthy man: effect of the continuous administration of metyrapone (SU 4885)].

In eight apparently healthy young men a circadian rhythm (P less than 0,05) in urinary 17-hydroxycorticosteroids (17 OHCS) and tetrahydro-11-deoxycortisol (THS) has been demonstrated before (A), during (B) and after (C) a 36 h sustained oral administration of metyrapone (7.50 g in ten doses of 0.75 g every 4 h). Subjects synchronization: light-on 0715; light-off 2300. 17 OHCS have the acrophase phi located at 1430 (2:30 p.m.) in the three circumstances. Only traces of THS are excreted during A. During B and C when THS is excreted, a circadian rhythm is validated (p less than 0.05) with a phi at 1430.

17-Hydroxycorticosteroids↗
PubMed1975

Aminoglutethimide and glutethimide: effects on 18-hydroxycorticosterone biosynthesis by human and sheep adrenals in vitro.

The conversion of [1,2-3H]corticosterone to 18-hydroxycorticosterone in vitro was studied on human and animal adrenal tissue homogenates. Human adrenals were surgically resected from a patient with Cushing's disease. Sheep adrenal homogenates were prepared from the pooled glands of 20 animals. Incubations supplemented with a NADPH generating system were performed in order to evaluate the effect of aminoglutethimide and its closely related compound glutethimide on corticosterone 18-hydroxylation in vitro. Increasing concentrations of the two drugs were assayed on both human and animal adrenal homogenates. Aminoglutethimide was clearly found to inhibit corticosterone 18-hydroxylation in sheep adrenal homogenates as a 72.6% inhibition occurred in the presence of only 0.2 mumole of the drug. Inhibition reached 91.1% in the presence of 0.5 mumole aminoglutethimide. When added to the human incubated adrenal, a 59.4% inhibition occurred in the presence of 0.5 mumole aminoglutethimide. Glutethimide, a sedative of wide clinical usage, was also found to inhibit corticosterone 18-hydroxylation but the inhibitory effect occurred only in the presence of much higher concentrations. In fact, 5.0 mumoles were necessary to obtain a 43.9% inhibition of 18-hydroxycorticosterone synthesis. This study clearly demonstrates the marked inhibitory effect of aminoglutethimide on corticosterone 18-hydroxylation. Glutethimide, to a lesser extent, also inhibits 18-hydroxycorticosterone synthesis.

18-Hydroxycorticosterone↗
PubMedDate not supplied

Circadian rhythms of adenosine deaminase activity in human erythrocytes: a transverse study on young, elderly and senile demented subjects.

Adenosine deaminase activity (ADA) was determined around the clock in human plasma from different groups of subjects: presumably clinically healthy women in Minneapolis, USA; healthy medical students, healthy elderly men and women, and mentally ill patients in Paris, France. In addition to analyses of variance, circadian characteristics were estimated individually and summarized by population-mean cosinor for each group. Technical and sampling considerations are documented: the individualized assessment of a circadian rhythm in adenosine deaminase is feasible in 8 out of 11 series from clinically healthy women covering 24h at 20-min intervals. A circadian population rhythm could be determined for the elderly men and women (p less than 0.05) and tentatively (p = 0.053) for the senile demented patients. A difference in circadian group rhythm characteristics found between the healthy elderly subjects and patients with senile dementia deserves further exploration.

Adenosine Deaminase↗
PubMedDate not supplied

Modifications of circadian and circannual rhythms with aging.

Whereas biological rhythms are now fairly well documented in young healthy adults, reports in elderly are relatively few for obvious reasons, including the difficulty of setting groups matched in age, sociological and professional background, medical history, and not in need of specific medication. Aging may modify one or several parameters characterizing biological rhythms. The modifications are different from one function to the next, and great care should be given not to mistake changes attributable to the aging process with those resulting from physical and physiological impairment caused by passed environmental aggressions and diseases. Nevertheless, the increasing number of subjects reaching the age of 65 or older, thanks to medical progress, makes necessary establishing time-qualified references values in the aged, as this kind of investigation should lead to an improvement of the conditions and quality of life of elderly subjects.

Aging↗
PubMedDate not supplied

[Obesity prevalence in Iaşi county].

UNLABELLED: Our study is a part of a national study initiated by ARSO (Romanian Association for Study of Obesity). We selected a statistically representative sample (1500 cases). Study was built upon a questionnaire, made by primary care physicians. Anthropometrical data evaluated the obesity (weight, waist circumference and body mass index, BMI) and we considered associated risk factors (cholesterol levels, diabetes, and hypertension). BMI, more than 25 and 30, defines overweight and obesity. Waist more than 80 cm, for women and 94 cm for men, was considered abdominal obesity. Prevalence of obesity was globally 28.69%, by BMI and abdominal obesity, 57.87%. Non-obese cases are mostly on 20-29 years (2:1), both sex and 30-39 years, mostly on women. After these decades, percents for overweight and obesity are, constantly, more on women (48%) than men (31.03%). Abdominal obesity rises constantly with age, between 42.8% and 73.04%. A lot of patient didn't know theirs cholesterol values, over 25%. The highest percent of high cholesterol is located on 50-59 years (42%) and 35.63% on previous decade. High number of menopausal women can explain this. CONCLUSIONS: 1. We consider a high prevalence of obesity, 28.69%, predominant on women and aged persons. 2. Abdominal obesity has higher prevalence, 57.87%. 3. There are multiple risk factors, especially on 50-59 years decades but are not searched sufficiently.

Adolescent↗
PubMedDate not supplied

CA-125 ovarian cancer associated antigen in cancer and pregnancy: interpretation of enzyme immunoassay and immunoradiometric assay.

Serum CA-125 concentrations were determined using both immunoradiometric assay (IRMA) and enzyme immunoassay (EIA) in 67 patients with various diseases including cancer and in 100 pregnant women with respect to the stage of pregnancy. Correlation of values obtained by the two methods was good except for the first and second trimester of pregnancy. However, IRMA concentrations were 80-200% higher than those obtained by EIA, the larger differences being observed in the critical range of 35-100 U/mL. Therefore, the alternate use of the two methods should be avoided and the cutoff levels should be redefined for each procedure.

Adult↗