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Biomedical subjects

A Bloch

Publications and source records attributed to A Bloch.

At least 163 records · Page 9Linked to original sources

[Rupture of the mitral valve chordae. Electrocardiographic, clinical and angiographic findings].

This report concerns 9 patients in whom rupture of the cordae of the mitral valve was suspected from the echocardiogram. The authors recall the clinical, echocardiographic, arteriographic, haemodynamic and anatomical findings in patients with rupture of the chordae; they emphasise the importance of echocardiograpy in the pre-operative diagnosis of this condition. In this series, the most frequent clinical sign was a loud pan-systolic murmur at the apex. The electrocardiographic abnormalities were nonspecific. Cardiomegaly was present in most cases. The main echocardiographic findings were those of additional echoes between the two cusps of the mitral valve during diastole, or an abnormally posterior or anterior position of the posterior cusp during diastole, or the presence of mitral prolapse. Other nonspecific signs were frequently present. Left cineangioventriculography showed a significant degree of mitral leakage during diastole in all patients. All 9 patients had an operation or came to post mortem; rupture of the chordae was confirmed in 6 of them. As far as the other 3 cases were concerned, two of them had lengthening of the mitral cordae, and the last had mitral prolapse associated with endocardial vegetation. A further group of 60 patients undergoing surgery for mitral incompetence without rupture of the chordae allowed us to establish that there were no false negative results on the echocardiogram.

Adult↗

A serological survey of Lassa fever in Liberia.

A serological survey was undertaken at four Liberian hospitals in 1974 in which serum samples were taken from 104 health workers and 61 patients. Six persons had Lassa fever antibodies: four midwives and two students of midwifery. Of those persons who had lived in Loffa County, 4 of 22 midwives were seropositive whereas none of the other 39 residents were positive (P = 0.014).

Adult↗

[Usefulness of echocardiography in the diagnosis of bacterial endocarditis].

Echocardiographic demonstration of vegetations has been achieved in 11 out of 19 patients with bacterial endocarditis. The present study shows that echocardiography is particularly useful in patients in whom the duration of symptoms before treatment is greater than 6 weeks. It also shows that a positive echocardiogram is indicative of a poor prognosis.

Echocardiography↗

[Prognosis for coronary patients with low ejection fraction. Comparison between a medically and a surgically treated group].

Two groups of coronary patients whose ejection fraction was depressed (less than or equal to 0.30) were studied. Twelve patients received drug treatment only and 25 others underwent surgery. Life expectancy appears to be slightly improved in the surgical group, but the differences are not statistically significant. Since operative mortality is relatively low (8%) and clinical improvement following surgery may be impressive, a revascularization procedure should be considered even in patients with markedly impaired ventricular function.

Coronary Disease↗

[Early mobilization in the acute stage of myocardial infarction long term results].

A report is presented on the continuation of a controlled study on early mobilization after acute myocardial infarction performed at the Cantonal Hospital of Geneva. Detailed follow-up studies were made in the patients from the original study 4 years on average after the myocardial infarction. It is well known that early mobilization offers many advantages over prolonged bed rest. The present study demonstrates that early mobilization after acute myocardial infarction involves no longterm risks.

Aftercare↗

Interobserver variability in echocardiography.

High-quality echocardiograms were performed on 146 normal individuals whose ages ranged from 3 to 73 years (mean 27 years). Normal values for mitral diastolic excursion and E-F slope, the chamber dimensions of the right ventricle, left atrium, and left ventricle, the aortic root dimension, and thickness of the interventricular septum and left ventricular posterior wall were determined. Each tracing was then read independently by two experienced echocardiographers. The extent of interobserver variability was calculated and expressed as a percent of the mean. The 95 per cent confidence limits for these estimates were calculated. Small but significant interobserver variability was found for all nine of these commonly measured echocardiographic parameters. Observer variability is a small but potentially important consideration in investigative echocardiography.

Adolescent↗

Echocardiographic spectrum of posterior systolic motion of the mitral valve in the general population.

The prevalence of mitral valve prolapse has been established in selected groups of patients but not in the general population. The present study was designed to define the echocardiographic spectrum of mitral valve motion in a population of young individuals without clinical evidence of significant cardiac disease or hypertension. Echocardiograms were performed on 136 normal volunteers. Six subjects (4.4 per cent) had mitral valve prolapse. Eighteen subjects (13.2 per cent) had a lesser degree of posterior systolic motion of the mitral valve leaflets which was suggestive but not diagnostic of prolapse. Minor degrees of posterior systolic mitral valve motion may represent a variant of normal. Caution should be exercised in making the echocardiographic diagnosis of mitral prolapse until this question is settled.

Adolescent↗

[Asymmetric septal hypertrophy. Echocardiographic and angiographic diagnosis].

Three cases of symptomatic asymmetric septal hypertrophy are reported. The echocardiogram allows a reliable diagnosis; it entails no risk to the patient and it may be repeated during the course of the disease. Associated with biventricular angiocardiography, the echocardiogram represents the method of choice in detecting these lesions.

Adult↗

[Coronary lesions in type II and IV hyperlipoproteinemias. Coronarographic study].

Coronary arteriography was performed in 24 patients with type-II and in 22 patients with type-IV hyperlipoproteinemia. The findings of the present study allow definition of several angiographic characteristics which seem to be linked to the type of hyperlipoproteinemia. Patients with type II generally have more widespread disease in the coronary tree at younger ages than do those with type IV. Type-II patients usually have proximal and distal disease, whereas type-IV patients have more often proximal disease only. Significant stenosis of the main left coronary artery is frequent in type-II but very rare in type-IV patients. Extensive calcification of the ascending aorta, sometimes associated with narrowing of the proximal aortic root, is present in 25% of type-II but in none of type-IV patients.

Angiography↗

Coronary arteriographic findings in type-II and type-IV hyperlipoproteinaemia.

Coronary arteriography was performed in 46 patients with type-II and type-IV hyperlipoproteinaemia. Type-II patients had a high prevalence of main left coronary disease and of distal coronary atherosclerosis, while type-IV patients usually had disease localised to the proximal coronary tree. These differences may be related to the differing plasma-lipoprotein patterns in these two syndromes.

Adolescent↗

Cephalothin-induced immune hemolytic anemia.

A patient with renal disease developed Coombs-positive hemolytic anemia while receiving cephalothin therapy. An anti-cephalothin IgG antibody was detected in the patient's serum and in the eluates from her erythrocytes. In addition, nonimmunologic binding of normal and patient's serum proteins to her own and cephalothin-coated normal red cells was demonstrated. Skin tests and in vitro lymphocyte stimulation revealed that the patient was sensitized to cephalothin and also to ampicillin. Careful investigation of drug-induced hemolytic anemias reveals the complexity of the immune mechanisms involved.

Anemia, Hemolytic↗