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Biomedical subjects

A Bisetti

Publications and source records attributed to A Bisetti.

At least 73 records · Page 4Linked to original sources
PubMed1984

Chemiluminescence measurement of phagocytic activity of pulmonary macrophages in sarcoid alveolitis.

The phagocytic activity of alveolar macrophages in a group of patients with stage I and stage II fresh sarcoidosis has been studied in comparison with a group of healthy volunteers. The phagocytic activity has been measured by means of chemiluminescent emission recording. While no difference in the emission of chemiluminescence has been detected in polymorphonuclear leukocytes of patients and control subjects, a greater emission of chemiluminescence has been noted in the alveolar macrophages of sarcoid patients. Such a difference is statistically significant; its possible relation to alveolar inflammation has been considered.

Adult↗
PubMed1984

Diffuse interstitial lung diseases: a histochemical approach.

72 cases of diffuse interstitial lung diseases were observed from 1969 to 1976. Specimens removed from 47 patients were subjected to the whole spectrum of reactions. According to variation of both elastin and collagen, the following groups were outlined: group A: mycobacteriosis, farmer's lung, sarcoidosis and silicosis; group B: chronic eosinophilic pneumonia, lymphocytic interstitial pneumonia, post-tuberculous pulmonary fibrosis, and group C: X-ray pneumopathy, desquamative interstitial pneumonia, sclerodermic pneumopathy and chronic pulmonary fibrosis (primary chronic fibroadenomyosis). Each of these groups presents a close relationship between histochemical, radiological, clinical and functional findings.

Collagen↗
PubMed1984

Spontaneous hydropneumothorax by severe pulmonary sarcoidosis.

A case of pulmonary sarcoidosis involving the pleura and complicated by spontaneous hydropneumothorax is reported. Diagnosis is made by cytological features of pleural effusion and confirmed by mediastinal biopsy. The rare occurrence of this clinical situation must be diagnosed because of the important therapeutic implications, but in any event it indicates the severity of granulomatous disease.

Adult↗
PubMed1984

Effects of methylprednisolone on sputum biochemical components in asthmatic bronchitis.

Nineteen patients with chronic mucus hypersecretion and reversible airway obstruction were studied during an acute exacerbation. One group of patients was treated with antibiotics and aminophylline, the other, additionally, with gradually decreasing doses of methylprednisolone, starting with 80 mg/day. The sputum specimens were collected on the day of admission and 2 weeks later. In whole sputum, we examined macromolecular components both transudated from serum and locally secreted: albumin, fucose, N-acetylneuraminic acid, total protein, IgA, IgM, IgG. At the end of the second week albumin (marker of serum transudate), and fucose (marker of mucus glycoproteins), were significantly lower in the group treated with corticosteroids. IgG and albumin behaved in the same way suggesting a marked IgG serum exudation. IgM was partially reduced by corticosteroids while IgA remained unchanged.

Adult↗
PubMed1982

[Anergic miliary tuberculosis, with principally splenic localization simulating hemolymphopathy. Report of 4 cases].

Four cases of disseminated tuberculosis with prevailing spleen involvement and lack of tuberculin reactivity are described. The atypical clinical picture justified, at the beginning of the disease, the suspect of a lymphoreticular disorder (malignant lymphoma in 3 cases) or of a pulmonary hemosiderosis (in 1 case). The splenectomy and the following anti-tubercular chemotherapy were fully successful in all 4 patients and the skin reactivity was restored. The Authors discuss the pathogenesis of the observed features and the differential diagnosis of the cases of tuberculosis with only extrapulmonary involvement. These cases represent today about 1/6 of the patients with postprimary tuberculosis.

Adolescent↗
PubMed1979

[Chronic bilateral pleural effusion, ungual dystrophies and diffuse lymphoedema by systemic hypoplasia (author's transl)].

To chronic pleuropathies of lymphatic origin were recently added clinical data of a systemic hypoplasia of a malformative origin (Samman-White syndrome). The association of lymphoedema in lower limbs, of yellow nail and other changes brought by lymphatic disorders enabled to attribute some inexhaustible pleural effusion to this syndrome which can develop in the adult, probably through the help of microtrauma or of oligosymptomatic infections. Immunological changes can accompany this affection and promote the subsequent start of malignant hemopathies; after a study done on the two personal observations reported here, the problem is discussed.

Aged↗
PubMed1977

Histological and histochemical pattern of phytohemagglutinin (PHA) skin test in patients with sarcoidosis.

Phytohemagglutinin (PHA) is a non-specific stimulant of blastogenic transformation and proliferation of T-lymphocytes in vitro. This material has been used for detection of a reduced lymphoblastic transformation in vitro and, as a skin test, for providing information in the evaluation of cellular immunodeficiency in man (BLAESE et al. 1973). As in sarcoidosis the immunological features are "depression of delayed-type hypersensitivity suggesting T-cell anergy and raised serum immunoglobulins suggesting B-cell overactivity", the authors used PHA skin test in comparison with patients with tuberculosis and M. Hodgkin. PHA positive reactions recorded at 72 hrs. were in 95% for sarcoidosis, 90% for tuberculosis and 5% for M. Hodgkin. But the histological and histochemical investigation of cutaneous biopsies demonstrated three significant differences at 72 hrs. in untreated patients with sarcoidosis compared to the material of tuberculosis patients: formation of lymphatic pseudo-follicles, an increased number of arteriovenous anastomoses and appearance of C-mucopolysaccharide (a histochemical marker of connective tissue in sarcoidosis). There were in sarcoidosis, unlike tuberculosis, blast cells, plasmocytes and a number of lymphocytes at 72 hrs. It is difficult for the authors to explain the different behaviour of the PHA skin test in sarcoidosis and tuberculosis. The appearance of the C-mucopolysaccharide might be a result of the raised serum level of IgM in patients with sarcoidosis.

Glycosaminoglycans↗
PubMed1977

[Frequency and characters of familial pulmonary sarcoidosis (author's transl)].

A report is given on familial sarcoidosis in four cases. These 4 cases comprise one brother-sister and one mother-son relationship. Brother and sister were young persons in the acute stage (Löfgren-syndrome). In the other two cases diffuse fibroses accompanied by severe functional disturbances were to be observed. In both relationships clinical and radiological picture, course of the illness and response to the treatment were similar: favourable in the first, unfavourable in the second relationship. The frequency of familial occurrence is said to be 3.7% of all sarcoidosis cases.

Adult↗
PubMed1976

Sarcoidosis in Europe: a cooperative study.

The data on the epidemiologic situation of sarcoidosis from 24 countries of Europe have been reviewed. The new facts seem to demonstrate that the differences between the frequency of this disease in the north and south are not real. The actual situation is dependent on the general knowledge of this disease and on the extent and intensity of the active detection of its asymptomatic stage. A new prospective cooperative study of the yearly incidence of all forms of sarcoidosis in the total population of at least some European countries would be desirable.

Adult↗