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Biomedical subjects

A Berger

Publications and source records attributed to A Berger.

At least 595 records · Page 33Linked to original sources

[Early repeated, limited excision of deep burns with immediate meshed autografting (author's transl)].

A case is reported of the successful treatment of severe, third-degree burns by early limited, but repeated electrocautery excision and immediate meshed autografting. The concept of such attempts to convert large areas of full-thickness burns into a clean closed wound by means of the described techniques if discussed. A decrease in morbidity and mortality can be anticipated when this procedure is carried out for the correct indications by an experienced specialist team. Particular attention must be paid to the optimum, patient-geared timing of each surgical stage.

Adolescent↗

Ribonuclease S-peptide. A model for molecular recognition.

The relationship of structure to function in the recognition of ribonuclease S-peptide by S-protein was studied by several methods. Liquid phase peptide synthesis was employed to generate analogs of S-peptide in which from 1 to 8 residues were deleted from the NH2-terminal end of the S-peptide. Additional derivatives were made by substitutions in the NH2-terminal three amino acids or by modifying the S-peptide analogs by trifluoroacetylation. The analogs were generated in the following way. S-Peptide was cleaved with chymotrypsin. The fragment obtained, RNase(9-20), was purified and lengthened step by step using liquid phase peptide synthesis. A second set of analogs were prepared by cleavage of CF3CO-S-peptide with elastase and the resulting CF3CO-RNase(7-20), similarly lengthened. The various analogs of S-peptide were tested in their capacity to combine with S-protein and regenerate biological activity as measured by Vmax and Kb. This work shows a positive contribution of every one of the first 8 NH2-terminal residues of S-peptide to the molecular recognition of S-protein in the presence of RNA substrate. Substitution of the first 3 residues by alanine or blocking of the free amino groups decreases recognition, indicating that the original primary structure is the most favorable one.

Amino Acid Sequence↗

Hypercalcemia.

Hypercalcemia is a potentially life-threatening metabolic disorder which may be effectively treated once its presence is recognized and its probable cause determined. The family physician should be aware of the various clinical circumstances in which hypercalcemia occurs and the appropriate initial therapy for patients who are symptomatic at the time of diagnosis. This paper provides a clear approach to the pathogenesis, diagnosis, and management of this problem.

Calcitonin↗

Further experience with interfascicular grafting of the median, ulnar, and radial nerves.

The results of interfascicular nerve-grafting, a procedure developed in 1964, were reported in The Journal in 1972 9. Between 1964 and 1972, defects in forty-three median, fourty-four ulnar, and sixteen radial nerves were grafted using this technique. Final functional results after a minimum follow-up of two years are known for thirty-eight patients with median, thirty-nine patients with ulnar, and thirteen patients with radial-nerve lesions. In the median-nerve cases useful motor recovery (M 3 or higher) was achieved in 82% and protective sensibility was restored in all but one. In all of the patients with ulnar-nerve lesions useful motor recovery (M 2+ or higher) occurred, while in 77% of the patients with radial-nerve lesions an M 4 or M 5 level of function was achieved. The majority of the patients with poor results had some unfavorable circumstance such as advanced age, severity of the original trauma, or long time interval before repair. Comparison of our results with those in other series indicates that interfascicular nerve-grafting gives results which are at least as good as those after epineural nerve suture under ideal conditions and better than those after neurorrhaphy under tension.

Adolescent↗

Transient neonatal hyperparathyroidism associated with maternal hypoparathyroidism.

The newborn infant of a mother with hypoparathyroidism following thyroidectomy showed transient hypercalcemia and hypermagnesemia. Hypophosphatemia, as found in adult hyperparathyroidism, was not noted in this case, or in three of five other reported cases of neonatal hyperparathyroidism secondary to maternal hypoparathyroidism.

Adult↗

[Computer sensomtery as objective examination of sensation in the finger area].

The authors described what they believe to be a more objective method for evaluation of sensation within the digital pulp. It requires the use of electronic equipment including EEG to record the evoked potentials. With further refinement this method should become a valid tool in the objective examination of sensory patterns.

Computers↗

[Comparative study of three commerical preparations for the detection of Australia antigen].

2,944 sera from blood donors (420 of them being new donors) were tested in four techniques: Counterelectrophoresis (CEP) and three commercial tests: Ausria II, Auscell and Hepanosticon. Over 10 HBs Ag detected by RIA, 8 were evidenced by the Auscell test and 6 by the Hepanosticon Test. False positive results (approximately 3%) represent a disadvantage to the reverse hemagglutination method; this rate increased considerably in a group of 386 patients sera also tested. The authors conclude that the results obtained with the reverse hemagglutination technique are nearing those of RIA.

Blood Donors↗

[The basis of tumor verification using thermography].

The gradient between interior body temperature and external temperature was gradually measured in young pigs, since their skin resembles the properties of human skin. The interior temperature appeared to extend to 2.5 cm under the surface of skin. Then it drops, at first slowly and from 1 cm under the surface rapidly. Tumors or inflammations can only warm the skin directly when their site is 1 cm or less under the skin. Tumors which lie deeper may warm the skin via reflex zones. Warming by heat conduction is prevented by convection. Heating plates inserted 1.8 cm and 2 cm under the skin surface and heated 5 degrees beyond surrounding temperature do not warm the skin surface. This can be demonstrated by thermography. The importance of these results for thermographic tumor diagnosis is discussed.

Animals↗

[Late results in the surgical treatment of camptodactylia].

Fifteen patients with camptodactyly were treated operatively by flexor tendon transfer for reconstruction of the muscle balance with or without arthroplasty. If necessary skin plasties were performed (Tab. 3). The follow-up time ranged from 3 to 12 years. The results show that the principal cause of the malformation is an imbalance between the flexion and extension forces. The best methods for correction of the flexion deformity were transfer of the superficialis tendon to the extensor apparatus or simple reinforcement of the apparatus in the region of the proximal interphalangeal joint. A major conclusion was that successful result will be obtained only in children and adolescents. Corrective operations in adults should therefore be no longer recommended.

Adolescent↗

[Radiation exposure during examination with a therapy simulator. 2. Radiation load on the examiner during radiography (measurements on the Alderson-Man phantom)].

In judging the risk incurred by persons professionally exposed to radiation, there is at present a more distinct tendency towards consideration of somatic effects - as e.g. somatic "crossing over", accidents of development, induction of cancer; thus more attention is paid to individual risk. For assessment of this radiation risk, the organ doses in question must be known; they can be estimated by means of the ascertained tissue-air-ratios, if the field of stray radiation from the X-ray equipment is known. To obtain data for statements with regard to the radiation load on the examiner during radioscopies with a therapy simulator, it was necessary to determine the stray radiation field of the X-ray apparatus. Therefore, using an Alderson-Man-phantom, the angular distribution of the local dose rate were measured at a tube voltage of 84 kV. The skin irradiation fields had dimensions of 25 cm2, 100 cm2, and 400 cm2 at the distances 50 cm, 100 cm, 150 cm, and 200 cm of the ionization chamber from the central ray. The measurements were performed on levels of 90 cm, 130 cm, and 160 cm above the floor. Some additional measurements aimed at a more exact investigation of the dependency of scattered radiation upon the tube voltage, the area of the radiation field, the distance from the central ray, and the height above the floor. The attenuation capacity of a light radioprotective apron (0.25 mm lead equivalence) was also determined. It turned out that, at a tube voltage of 84 kV, the apron still was passed by about 3.6% of the hitting stray radiation. The present measurements yield important indications of the best possible locations of the examiner during radioscopy. A practical example is given showing how to assess the radiation load on single organs; the results show that the examiner is exposed to a gonadal load of about 2 mR and to a load of about 17 mR on the crystalline lenses, while engaged in preparative roentgenologic measures for intrauterine transfusions.

Humans↗

Cystic thymoma simulating contrictive pericarditis. The role of echocardiography in the differential diagnosis.

A case is presented of a 60-year-old woman with fatigue, dyspnea, and chest pain. A chest x-ray film revealed an abnormal cardiac silhouette. Echocardiography revealed a large, echo-free area with well-demarcated, discrete borders adjacent to the right heart border. This structure decreased in size with inspiration and did not show pulsatile cardiac motion. Cardiac catheterization confirmed the extracardiac nature of the lesion and also showed a "constrictive" pattern with equalization of diastolic pressures. Surgical exploration revealed a large cystic thymoma. With removal of the tumor, intracardiac pressures returned to normal.

Cardiac Catheterization↗

[Reestablishment of sensation in the distal phalanges using innervated flaps or grafts].

The authors describe a full thickness skin graft taken with its cutaneous nerve for the coverage of skin defects in the area of the distal phalanx for defects involving the pulp. The defect was covered by a cross-finger flap; its collateral nerve was raised with it and then anastomosed with the injured digit's nerve, using the operating microscope. Either of the above methods permitted improved sensory return.

Adolescent↗