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Biomedical subjects

A Berger

Publications and source records attributed to A Berger.

At least 577 records · Page 32Linked to original sources
PubMed1979

Enhancement of radioresponse of a mouse mammary carcinoma to combined treatments with hyperthermia and radiosensitizer misonidazole.

The regrowth delay of a transplanted syngeneic mouse mammary carcinoma designated MT2 was used to estimate the effects of three-fold combination treatments: X-irradiation; hyperthermia and radiosensitizer; and misonidazole (Ro-07-0582). The experiment entailed five groups of experimental mice: untreated control; X-rays alone; X-rays plus hyperthermia (42--43 degrees); X-rays plus misonidazole; and X-rays plus hyperthermia plus misonidazole. X-Ray treatments consisted of 4000 rads administered locally to the tumors in two equal fractions at a 48-hr interval. Misonidazole (0.67 mg per g body weight) was injected i.p. 30 min before exposure to X-irradiation. Hyperthermia was administered 10 min prior to and for 17 min during irradiation. The regrowth delay factor of 3.9 was obtained by administering combined treatments of the three agents (X-rays plus hyperthermia plus misonidazole). The enhancing effect on a syngeneic mouse mammary adenocarcinoma by the modality of treatment herein described lends support to the usefulness of combining X-rays with other agents in the treatment of neoplasms.

Adenocarcinoma↗
PubMed1978

Replantation and revascularization of amputated parts of extremities: a three-year report from the Viennese replantation team.

A Replantation Team was instituted in Vienna 3 years ago. This team is the oldest in Europe. One hundred and eighty-one complete and incomplete amputated parts of 118 patients were replanted during this period. A survival rate of 86% and a useful functional result ("integrated parts") in 78% of the cases was obtained. Appropriate preparation of the amputated parts, the right timing, a 24 hour service and a clear indication with intensive postoperative physicotherapeutical treatment are the fundamental points for this result.

Amputation, Traumatic↗
PubMed1978

Nerve grafting.

By avoiding tension and securing anatomical neurorrhaphy, regeneration of nerve is obtainable. When the gap exceeds a certain limit, the only way to avoid tension is the use of grafts. Experience in animal experiments and clinical practice has demonstrated that regenerating axons can cross 2 optimal suture lines much more easily than one sub-standard one. For bridging a gap autografts are used, because in autografts the fascicular pattern is preserved and its Swann cells survive. With the interfascicular technique the dissection of the nerve stumps proceeds from normal to abnormal tissues and the epineurium is resected. The coaptation must be exact so that the grafts cover the whole cross sectional area of the fascicle. All this can be achieved by the use of one 10--0 or 11--0 nylon suture. The clinical results show that in the median nerve 82%, in the ulnar 80% and in the radial nerve 92% of good functional results can be obtained. Also in brachial plexus injuries the interfascicular nerve grafting procedure opened new ways. Therefore interfascicular nerve grafting, using autografts in cases of nerve repair, where a gap may occur, currently is the method of choice.

Animals↗
PubMed1978

[Impairment of the skeletal growth of the hands after electrical burns in childhood].

Fourteen children with electrical burns involving 33 fingers were followed for a period of more than 8 years. Primary treatment was conservative in 17 fingers, of which 11 required surgery at a later date. Adequate function was restored in 12 fingers after completion of this treatment and persisted for 8 years and more. In 5 fingers substantial joint deformities developed. For 16 fingers surgery was required as primary treatment. Bone involvement was present in 10 of these. Secondary surgery proved to be necessary in 2 fingers, on one aseptic necrosis necessitated replacement by a bone graft. All of the 16 fingers showed good function in the period under review. There was no radiological evidence of deformities, but growth was substantially slower than normal. Apparently coverage of exposed bone with well vascularized tissue improved local blood flow so that damage other than that originally produced by the electrical burns was prevented.

Burns, Electric↗
PubMed1978

[Experiences with 2-stage flexor tendon transplantation].

Flexor tendon grafting in two stages, using silastic rods to prepare a new bed, is well known. In our opinion four indications are important: first -- loss of tendon and gliding surface due to infection or complex injuries; second -- lesions of the digital nerves; third -- defects of the skin and fourth -- replantation of amputated digits. We are convinced that two stage tendon grafting is a helpful concept for achieving reasonable functional results in special cases and complex injuries.

Adult↗
PubMed1977

[Surgical indications in lesions of the brachial plexus].

The development of microsurgery and the improved technique of nerve grafting brought new hope in cases of brachial plexus injury. Especially the Tinnel-Hofmann sign is a very helpful parameter in preoperative examination. Cases without any regeneration or no advancement should be operated between 3 and 6 months after the injury. Neurolysis or nerve grafting should be performed. In cases of avulsion of the roots a reneurotisation by nerve transfer is the technique of choice. The intercostal nerves are connected with important parts of the brachial plexus. Also in late cases (after 6 months) an epineurectomy and neurolysis may help to encourage further regeneration. Useful recovery could be achieved in a fairly high number of patients by restoration of continuity by nerve grafts or neurolysis. The functional results can further be improved by exploiting all available reconstructive techniques.

Angiography↗
PubMed1977

[Chances in the serum lipid values after conversion to a "reasonable" diet (author's transl)].

Six to ten days after conversion from usual alimentary habits to a so-called "reasonable" regimen, the serum concentrations of different lipid fractions were examined under standardized conditions, in a total of 325 in-patients, who had not been pre-treated, and 268 of whom showed - after diverse examinations - a hyperlipoproteinaemia; the other 57 patients had normal lipid values. This diet food is vitamin-rich, poor in calories, protein-rich with a 20 per cent to 25 per cent part of calories, poor in carbohydrates (maximum 120 g/day), and extensively renouncing monomeric and dimeric carbohydrates; furthermore, it contains a percentage of 40 to 45 calories of lipids with a standardized part of multiple-unsaturated fatty acids. During the period of observation, there was in none of the patients an alteration of the body-weight exceeding 1 kg. During the period of the regimen, the following highly significant decreases - without any medicamentous measures - were stated with regard to the serum concentrations: Total cholesterol (average) 9.9 per cent, triglycerides (average) 23.1 per cent, beta-cholesterol (average) 17.6 per cent, and phosphatides (average) 14.2 per cent - all percentages being in relation to the reference values. A hyperproteinaemia (type IIa/Fredrickson) disappeared in 14 out of 18 cases, a hyperlipoproteinaemia (type IIb) in 14 out of 44 cases, and the same happened with this disease type IV in 114 out of 206 cases. A change of type was stated 16 times.

Adult↗
PubMed1977

[Errors in practising a so-called "reasonable" regimen (author's transl)].

The significant decrease of the serum concentrations of total cholesterol, triglycerides, phosphatides, beta-cholesterol, and beta-lipoproteins, which usually is observed after conversion from normal eating habits to a "reasonable" diet, is prevented by supplementary and unverifiable consumption of confectionery and/or by alcohol abuse in irregular intervals. The so-called "reasonable" regimen is a high-fat and protein-rich diet food containing more than 50 per cent of multiple-unsaturated fatty acid in the fat supply. The fact that the average serum concentrations of the divers lipid fractions within the entire group of the 30 patients examined (patients who - admittedly - were practising a luxury form of consumption) showed merely insignificant fluctuations, is in no way a justification for the conclusion that a "reasonable" diet will at any time ostensively represent a protection against the effect of luxury consumption on the serum lipids.

Adult↗
PubMed1977

[Complications and failures through negative selection in replantation of amputated extremities].

Two years of experience with our replantation service in Vienna serves to define the criteria by which an amputated member is deemed worthy of replantation. 68 cases are analyzed and the complications and failures are discussed. The criteria took into account the type of injury, the ischemia time, the method adopted to preserve the severed part as well as the functional need of the amputee. We believe that by today's standard of replantation surgery, with the aid of microsurgical methods a responsible approach to indications would improve the functional results. Replantation capability, replantation possibility, replantation readiness and replantation obsession are all discussed.

Adolescent↗