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Biomedical subjects

A Barone

Publications and source records attributed to A Barone.

At least 73 records · Page 4Linked to original sources

Diurnal cycle of core temperature in huddling, week-old rat pups.

Lean Zucker rat pups were reared at 25 degrees C on four staggered 12:12 light:dark cycles with lights on at 0100, 0700, 1300 or 1900 hr. Core temperature (Tc) of 5- to 8-day-old pups was measured repeatedly at the rearing temperature of 25 degrees C between 0700 and 1900 hr using a procedure that minimally interfered with spontaneous nursing cycles and huddling of the pups. Tc of litters measured 30 to 60 min after the mother spontaneously left the nest was low and variable (32.2-35.4 degrees C) during the first few hours after lights-on, but was uniformly high and much less variable (35.5-36.5 degrees C) around the time of lights-off. Pup Tc was phase-advanced to the nocturnal elevation of maternal Tc, and lagged several hours behind the diurnal elevation of nursing activity. Cyclic variations in Tc of pups huddling in the nest thus reflect a diurnal rhythm in the ability and/or drive for body temperature defense that is independent of heat derived from the mother during nursing.

Animals↗

[Diuretics].

Explore the source record for details and available documents.

Aldosterone↗

Clinical pharmacology of DEAE-dextran for long-term administration (one year).

Twenty-eight patients with hyperlipoproteinaemia types II and IV according to Fredrickson were treated for one year with diethylaminoethyl-dextran (DEAE-D). The drug, used at a daily oral dosage of 2 to 3 g, proved very effective in reducing both blood cholesterol and triglycerids (mean reduction was 24 percent and 31 percent respectively). The drug also proved itself to be remarkably free from side-effects, as assessed both by a comprehensive check of biochemical parameters as well as by the patients themselves. The results obtained confirm the hypolipaemic effectiveness of DEAE-Dextran, due to an increased elimination of bile acids and fatty acids by the G.I. route.

DEAE-Dextran↗