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Biomedical subjects

A Baraka

Publications and source records attributed to A Baraka.

At least 217 records · Page 12Linked to original sources
PubMed1984

Hemodynamic effects of diazepam-vecuronium-fentanyl sequence for induction of anesthesia for coronary artery surgery.

The hemodynamic effects of diazepam (0.2 mg/kg)--vecuronium (0.2 mg/kg)--fentanyl (10 micrograms/kg) sequence was investigated when used for induction of anesthesia and tracheal intubation in eleven patients undergoing CABG. The parameters monitored included HR, SBP, PAP and PCWP. Also, EKG was monitored via a modified V5 lead and C.O was measured by thermodilution. SVR, PVR and SV were computed from the measured parameters. Following induction of anesthesia by diazepam-vecuronium-fentanyl sequence, there was a decrease in SBP by 20.0% (P less than 0.05), in HR by 15.7% (P less than 0.001) in C.O by 13.3% (P less than 0.01) and in SVR by 13.6% (P less than 0.05) of control value. There were no changes in PAP, PCWP, PVR and SV. Coronary perfusion pressure and heart rate product were both decreased following this induction sequence. However, the percentage decrease in PR was higher than that of CPP, affecting favorably the myocardial oxygen supply-demand balance. Orotracheal intubation was followed by an increase of HR by 10.7% (P less than 0.05), SVR by 13% (P less than 0.05) and PCWP by 26% (P less than 0.05) of preceding value. However, all these values did not reach the control awake values. It was concluded that diazepam (0.2 mg/kg)--vecuronium (0.2 mg/kg)--fentanyl (10 micrograms/kg) sequence does not produce serious hemodynamic changes when used for induction of anesthesia and tracheal intubation in patients undergoing coronary artery bypass surgery.

Anesthesia↗
PubMed1984

Moderate hypothermia during carotid endarterectomy.

The present investigation reports 6 cases undergoing carotid endarterectomy, who were operated under moderate hypothermia (28.5-31.5 degrees C) without the use of a shunt; no neurological sequelae were observed post operatively. Moderate hypothermia is recommended as one of the techniques for brain protection in patients undergoing carotid endarterectomy.

Aged↗
PubMed1983

Succinylcholine-vecuronium (Org NC 45) sequence for cesarean section.

Vecuronium (Org NC 45) was used in 27 parturients undergoing elective cesarean section under general anesthesia. One of the parturients had a twin pregnancy. Neuromuscular transmission was assessed clinically by stimulating the ulnar nerve and observing the contraction of the fingers. An initial bolus of 0.05 mg . kg-1 of vecuronium was injected after recovery from succinylcholine block. Complete neuromuscular block resulted in all cases and lasted for a mean duration of 19.3 +/- 6.02 min. Muscular relaxation was maintained by incremental doses of 0.01 mg . kg-1 of vecuronium. Administration of vecuronium did not cause significant changes in blood pressure, pulse rate, or plasma cholinesterase activity. Also, there was no correlation between the plasma cholinesterase activity and the duration of neuromuscular block of vecuronium. The residual neuromuscular block could be antagonized at the end of the procedure by a mixture of 0.005 mg . kg-1 of glycopyrrolate and 0.025 mg . kg-1 of neostigmine. In all parturients, antagonism was adequate as evidenced by maintained tetanic response (50 Hz for 5 sec) and sustained head lift. Nine infants were delivered before the injection of vecuronium; 19 infants were delivered after its injection. There was no significant difference between the Apgar scores in the two groups, suggesting that vecuronium does not cross the placenta in concentrations that affect the newborn. Vecuronium may be advantageous in parturients undergoing cesarean section under general anesthesia because it maintains cardiovascular stability, is noncumulative, is readily antagonized by neostigmine, has no effect on the plasma cholinesterase activity, and has no deleterious effect on the newborn.

Anesthesia, General↗