Search PubMed⌕ Search

Biomedical subjects

A B Miller

Publications and source records attributed to A B Miller.

At least 307 records · Page 17Linked to original sources
PubMed1980

Evaluation of a diet history questionnaire for epidemiologic studies.

This study was conducted to evaluate a detailed diet history questionnaire. Diet histories obtained from 16 men were compared with food records kept by their partners for a 30-day period. Mean estimates for all 13 nutrients calculated were higher with the diet history than with food records. Positive correlation coefficients were found between estimates from the two methods for all nutrients as well as food groups and six of the 13 nutrients gave a good fit for the corresponding regression equations. The questionnaire was also evaluated by repeating it after six months on 26 case-control pairs of an ongoing diet and cancer study. High correlation coefficients were obtained for most nutrients for the controls. However, cases showed lower correlations probably due to changes in their diet. The study found that the diet history method as an estimate of dietary patterns among groups shows sufficient validity and reliability to make it a useful instrument for epidemiologic studies.

Adult↗
PubMed1980

Tobacco use, occupation, coffee, various nutrients, and bladder cancer.

In a Canadian population-based case-control study of 480 males and 152 female case-control pairs, the relative risk for development of bladder cancer for ever used versus never used cigarettes was 3.9 for males and 2.4 for females, with a dose-response relationship in both sexes. A reduced risk was associated with the use of filter cigarettes compared to nonfilter cigarettes. After control for cigarette usage, a significant risk was noted for male pipe smokers. For male ex-smokers the risk after 15 years of no smoking was less than one-half that of current male smokers. Bladder cancer risk was found for workers in the chemical, rubber, photographic, petroleum, medical, and food processing industries among males and for workers occupationally exposed to dust or fumes among both sexes. Bladder cancer risk was elevated for males consuming all types of coffee, regular coffee, and instant coffee and for females consuming instant coffee, but no dose-response relationship was found. Risk was found for males consuming water from nonpublic supples but not for females. No risk was observed in males or females consuming nitrate-containing foods, beverages other than coffee, or fiddlehead greens. Hair dye usage in females and phenacetin usage in males and females carried no risk. Divergent findings by area for aspirin suggested that an overall association was not causal. Reevaluation of the data on artificial sweeteners confirmed a significant bladder cancer risk in males and a dose-response relationship. The cumulated population attributable risk for bladder cancer was 90% for males from cigarette smoking, industrial exposure, and exposure to nonpublic water supplies and 29% for females from cigarette smoking, industrial exposure, and instant coffee consumption.

Age Factors↗
PubMed1980

Cancer incidence and mortality in relation to occupation in 700,000 members of the Canadian labour force.

The mortality and cancer incidence experience of a 10% sample of the Canadian labour force has been monitored by using computerized record linkage to the Canadian National Mortality and Cancer Incidence Data Bases. Occupation and industry data are available for the sample for the years 1965-1971, and the data are being used both to generate and test hypotheses concerning occupational exposures and increased risk of various cancers. It is planned to continue the monitoring process in future years, and as the number of cancer cases and deaths in the cohort accumulate, the data will provide an increasingly valuable utility for cancer researchers.

Adult↗
PubMed1979

The chemotherapy of plasma-cell myeloma and the incidence of acute leukemia.

Previously untreated patients with myeloma were randomized to initial treatment with melphalan and prednisone (and to cyclophosphamide or carmustine if relapse or progression occurred)(Group A, 125 patients), melphalan, cyclophosphamide, carmustine and prednisone in alternating (Group B, 123 patients) or concurrent (Group C, 116 patients) schedules. The groups were similar with respect to known prognostic factors. Response rates and survival were also similar. We were unable to identify a subgroup of patients who responded or survived better on melphalan-cyclophosphamide-carmustine and prednisone than on melphalan and prednisone. We conclude that the combination of the four drugs is not better than melphalen and prednisone for inducing responses or prolonging the survival of patients with myeloma. Myelomas producing only gamma chains have a poorer prognosis (P greater than 0.001) than IgG, IgA, or kappa myeloma. Acute leukemia has developed in 14 patients. The actuarial risk of developing acute leukemia, has increased rapidly to 17.4 per cent at 50 months.

Acute Disease↗
PubMed1979

Oral administration of BCG as an adjuvant to surgical treatment of carcinoma of the bronchus.

A controlled clinical trial of the value of bacille Calmette--Guérin (BCG) vaccine given orally to patients with resectable carcinoma of the lung was conducted in 18 centres across Canada. A total of 308 patients were included in the analysis, 155 in the BCG group and 153 in the control group. The two groups were similar at the time of admission to the trial. BCG (120 mg) was given orally at weekly intervals for 1 month, every 2 weeks up to 3 months and then every 3 months until the total duration of therapy was 18 months. Over a 3- to 5-year follow-up period after the operation there was no difference in survival between the two groups, the proportion alive at 2 years being 61% in the BCG group and 58% in the control group. There was also no evidence of differences in the time to the detection of recurrent or metastatic disease or in the distribution of such disease. An analysis of prognostic factors confirmed the poor survival associated with histologically confirmed lymph node involvement. It may be concluded that no favourable effect from the oral administration of BCG was demonstrated.

Adjuvants, Immunologic↗
PubMed1979

Isoniazid exposure in relation to cancer incidence and mortality in a cohort of tuberculosis patients.

41 226 isoniazid exposed and 22 811 non-exposed patients admitted to Canadian institutions for the treatment of tuberculosis from 1952 to 1960 were followed to 1973 by computerised record linkage to the National Death Index and, for 1969 to 1973, to the National Cancer Incidence Reporting System; The mortality for the total cohort compared to that expected from the mortality in the Canadian population, was greater than expected for tuberculosis, other chest diseases and certain cancer sites associated with cigarette smoking (except bladder cancer). There was, however, no difference between the isoniazid-exposed and non-exposed in mortality from all cancer and individual cancer sites, except for oesophageal cancer in males. Cancer incidence from 1969 to 1973 was also similar for the isoniazid- exposed and non-exposed groups. An elevated standardised incidence ratio was seen only for buccal cavity and pharynx in male exposed subjects. It is concluded that this study provides additional negative evidence on the carcinogenicity of isoniazid in man.

Adolescent↗
PubMed1979

Early treadmill testing after myocardial infarction: Angiographic and hemodynamic correlations.

Twenty-eight patients who were two weeks post acute myocardial infarction walked on a motorized treadmill at 1 MPH 0 percent grade for five minutes (group 1) or to an end-point of symptoms, ST-T wave changes or arrhythmias (group 2). At subsequent cardiac catheterization, 73 percent in group 1 had single vessel coronary artery disease whereas 82 percent group 2 had three or four vessel coronary artery disease. Ejection fraction was better in group 1 as was the slope of a modified left ventricular function curve. We conclude that limited exercise treadmill testing soon after acute myocardial infarction may be useful in predicting the extent of coronary artery disease and the amount of left ventricular dysfunction.

Acute Disease↗
PubMed1978

A comparison of dietary methods in epidemiologic studies.

Three methods of estimating group and individual dietary consumption have been developed and assessed in a case-control study of diet and breast cancer. The methods comprised a 24-hour recall, a detailed quantitative diet history directed to the most recent two-month period and the two-month period six months before, and a four-day diet diary. There is a high degree of correlation between the estimates of food consumption for the controls using each of the methods. The highest estimate was obtained from the diet history, with a slightly higher estimate in the period six months before than the current period, while the lowest is found in the 24-hour recall. The latter corresponds with the same method in a Nutrition Canada Survey. It is concluded that all methods ara applicable to case-control studies, but the diet history is preferred when current food intake may be influenced by a disease.

Breast Neoplasms↗