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Biomedical subjects

A Axelsson

Publications and source records attributed to A Axelsson.

At least 109 records · Page 6Linked to original sources

Acute maxillary sinusitis--a comparison between 27 different treatment modes.

When comparing the outcome of different treatment modes for acute maxillary sinusitis, the roentgenological examination can be recommended for the objective evaluation as a complement to the clinical examination. Using the occipito-mental projection and an additional occipito-mental side view, the diagnosis can be established in a cheap and simple way, and the treatment effect can be followed during the course of treatment in the form of radiological sinus changes. The treatment outcome of 27 different treatment modes in 1320 cases of acute maxillary sinusitis (2039 maxillary sinuses) was compared. There was little difference between the treatment groups as to therapeutic effect, whether using antral drainage alone, antibiotics alone or the combination of both. Factors other than treatment outcome must be important for the consideration of treatment choice, e.g. pharmacokinetics, administration, dosage, treatment cost, number and type of side effects, etc.

Anti-Bacterial Agents↗

Cochlear vascular histology in animals exposed to noise.

The regularly occurring cochlear vessels in the external wall and spiral lamina were studied in the guinea pig and chinchilla following exposure to various types and durations of noise. A soft-surface specimen technique with or without injection of a contrast medium into the vascular system was used, and the occurrence of specified vascular parameters was assessed using phase-contrast microscopy. Noise does not seem to result in any extraordinary vascular pathology, but a slight, overall decreased blood supply to the cochlea and localized changes depending on cochlear turn are suggested.

Animals↗

Noisy leisure time activities in teenage boys.

An increasing incidence of a high tone hearing loss in teenagers has been demonstrated in recent years. The hearing loss is sensorineural, and looks like an early noise-induced hearing loss with a dip at 6 kHz. It has been discussed whether this is due to noisy leisure time activities or to heredity. Five hundred thirty-eight boys from technical vocational schools were questioned with regard to leisure time activities. Hearing tests showed a normal mean audiogram with a marked dip at 6 kHz. Fifteen percent of the boys showed some hearing loss; more than 20 db HL on one frequency. Many teenagers had noisy leisure time activities, particularly related to pop music. No correlations could be found between hearing loss and the leisure time activities. The only marked correlation was for hearing loss at 4, 6 and 8 kHz on the left ear and a family history of hearing loss. We argue that heredity deficiency could reveal itself as an increased noise sensitivity with a resultant early noise-induced hearing loss at a young age. Much more attention should be devoted to the noisy activities of teenagers.

Adolescent↗

Early noise-induced hearing loss in teenage boys.

A hearing examination of 538 teenage boys in vocational school classes--implying future on-the-job noise exposure--showed a hearing loss (greater than 20 dB HL at any frequency) in 15% of the cases. Few correlations could be demonstrated between hearing loss and specific leisure time activities. There was, however, a correlation between high frequency hearing loss in the left ear and hereditary hearing loss. The most affected frequency was 6 kHz, suggesting a noise etiology--a suggestion emphasized by the noisy hobbies of these teenagers. It cannot be excluded that a hereditary deficiency could either manifest itself as a localized dip at 6 kHz or reveal itself as an increased vulnerability to noise, identified at young age as a high frequency dip at 6 kHz.

Adolescent↗

Some vascular effects of noise exposure in the chinchilla cochlea.

Chinchillas were exposed to pink noise at levels ranging from 110 dB (for 8 h) to 125 dB (for 1/4 h). After a 3-week survival period, the animals were terminated without anesthesia and tissues were prepared using a soft-surface preparation technique [Axelsson et al., Acta Otolaryngol. 80, 362 (1975)]. Cochlear hair cell damage as well as vascular pathology was slight. On occasion, a vessel or vessel segment was obviously atypical, thus allowing noise-exposed animals to be differentiated from their non-noise-exposed controls. More often, however, differences between animals were more discrete and only evident through a computer analysis of the data. The specific effects of these particular noise-exposure parameters on the cochlear blood supply of the chinchilla will be discussed.

Animals↗

Methodological aspects of some inner ear vascular techniques.

Modifications of preparation technique assessing cochlear vasculature together with suggestions regarding their applicability to various types of research projects are presented. Detailed information is given regarding the 'soft-surface' dissection and preparation technique along with selected parameters for evaluating the cochlear vasculature. Some basic requirements for any histological technique studying the inner ear blood supply are suggested.

Animals↗

Temporary threshold shift after exposure to pop music.

Temporary threshold shift (TTS) was studied in pop musicians as well as in listeners. It appears that TTS is less pronounced in pop musicians than in listeners. This can only in part be explained by slightly inferior hearing threshold levels than in the audience before exposure. Further, male listeners showed more TTS than female listeners. After 2 hours of exposure to live pop music a TTS2 appears in pop musicians after an exposure to 98 dB(A) as opposed to listeners where TTS2 appears at 92 dB(A). When the present results are related to the CHABA risk criteria it seems that exposure to live pop music at 100 dB(A) for 2 hours is a limit which should not be exceeded if the risk of permanent hearing loss is to be avoided.

Acoustics↗