Biomedical subjects
Publications and source records attributed to A A Grosu.
The clinical picture and the results of bicycle ergometry and selective coronarography were compared with the findings of electrical stimulation of the left atrium in 24 patients. It was demonstrated that transesophagus electric stimulation of the left atrium may serve as a diagnostic method in coronary heart disease.
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Potentialities of the non-invasive method of trans-esophagus electrostimulation of the heart were studied with regard to the selection and assessment of the effectiveness of antiarrhythmic therapy in 16 patients with paroxysms of supraventricular reciprocal tachycardia. The antiarrhythmic therapy selected by this method proved effective in 13 patients following a prolonged course of treatment. The method was highly informative in predicting the efficacy of the systemic course treatment of patients with supraventricular tachycardia paroxysms.
Thirty-one patients with paroxysms of supraventricular tachycardia (SVT) were examined using trans-esophagus electrical stimulation of the left atrium. SVT paroxysms were provoked in 23 patients. An analysis of the esophagus electrogram recorded revealed SVT paroxysms in the presence of the latent Wolff-Parkinson-White (WPW) syndrome in 12 patients, orthodromic SVT in the presence of the WPW syndrome in seven, and paroxysmal reciprocal atrioventricular node tachycardia in four patients. Paroxysms were also induced in three out of 8 patients with atrial fibrillation. Two patients displayed a fall in the ST segment.
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The paper presents data on an electrophysiologic action of disopiramid injected intravenously in a dose of 2 mg/kg on the function of the atrioventricular conduction system in 11 patients with paroxysmal supraventricular tachycardias. Disopiramid reduced the length of the spontaneous cardiac cycle and slightly affected the corrected sinus node recovery time and sinoatrial conduction time. The drug prolonged the intraatrial conduction time, increased the refractoriness of the His-Purkinje system and accessory conduction pathways. It produced no significant action on the refractory period and the function of the A-V node.