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At least 19 recordsLinked to original sources
PubMed2025

ADHD in Youth With Major Depressive Disorder in the Texas Youth Depression and Suicide Research Network (TX-YDSRN): Clinical Correlates and Moderators.

OBJECTIVE: Depression is a major public health concern with a 19% lifetime prevalence in youth, often precipitating other concerns, including suicidal behavior, poor school performance, and worsened peer relationships. ADHD is also common among youth and frequently presents alongside major depressive disorder (MDD), with this comorbidity associated with increased impairment. More research is needed to elucidate the clinical characteristics of this comorbidity (MDD + ADHD), especially as it relates to youth with MDD and no ADHD (MDD - ADHD). The present study examined the clinical correlates of MDD + ADHD in youth and the presence of an ADHD diagnosis as a moderator of the relationship between depressive symptoms and suicidality, peer relationships, and school functioning, respectively. METHODS: Our sample included 797 youth with MDD ages 8 to 20 years (Mage = 15.5 years) with and without ADHD. RESULTS: Youth with MDD + ADHD experienced more severe depressive symptoms, higher levels of suicidality, impulsivity, and irritability, and worse academic performance compared to those with MDD - ADHD. ADHD diagnosis did not moderate the relationships between depression severity and suicidality, peer relationships, or school functioning, respectively, suggesting that having an ADHD diagnosis may not affect these outcomes in depressed youth in this way. CONCLUSION: Findings shed light on the impact of ADHD in depressed youth, which may allow for earlier and more tailored intervention efforts aimed at identifying and targeting depression, suicidality, peer relationships, and school functioning.

Humans↗
PubMed1977

[Investigations on the extension of smoking among the working youth of the German Democratic Republic and on the smoking habits of Leipzig Youth].

In an extensive study performed in 1975 the extent of smoking among 4000 working adolescents of GDR was analysed. The results are approximately representative for the whole working youth of GDR in the age period of 17 to 25 years. The portion of smokers is represented approximately in dependence on socio-demographic factors and on social positions. The main results are as follows. 45% of the working youth in GDR are smokers; 55% being among male adolescents and 36% among female ones. The increasing extension of smoking habits must be first of all attributed to the growing proportion of female smokers. From all seizable influencing factors the levels of education and qualification have the most significant effect to the proportion of smokers to nonsmokers, the percentage of smokers significantly decreasing with increasing level of education and qualification. More detailed data on the smoking habits of adolescents are based on a longitudinal study of the Zentralinstitut für Jugendforschung begun in 1968 and continued every year in the same population investigating the development of the personality of adolescents and its determination in 600 Leipzig pupils of the 6th form. Onset of smoking, occasional and habitual smoking, average cigarette consumption per day and motivation for nonsmoking are analysed. Conclusions are drawn from these investigations for the prevention of smoking.

Adolescent↗
PubMed2025

Psychiatric Polygenic Risk Scores and Week-by-Week Symptomatic Status in Youth with Bipolar Disorder: An Exploratory Study.

Introduction: Prior studies have demonstrated that, in both adults and youth, bipolar disorder (BD) is a polygenic illness. However, no studies have examined polygenic risk scores (PRSs) in relation to the longitudinal course of mood symptoms in youth with BD. Methods: This study included 246 youth of European ancestry with BD (7-20 years old at intake) from the Course and Outcome of Bipolar Youth study and Centre for Youth Bipolar Disorder. Mood symptom severity was assessed at intake and, for 168 participants, prospectively for a median of 8.7 years. PRSs for BD, schizophrenia (SCZ), major depressive disorder (MDD), and attention-deficit/hyperactivity disorder (ADHD) were constructed using genome-wide summary statistics from independent adult cohorts. Results: Higher BD-PRS was significantly associated with lower most severe lifetime depression score at intake (β = -0.14, p = 0.03). Higher SCZ-PRS and MDD-PRS were associated with significantly less time spent in euthymia (SCZ-PRS: β = -0.21, p = 0.02; MDD-PRS: β = -0.22, p = 0.01) and more time with any subsyndromal mood symptoms (i.e., any mania, mixed, or depression symptoms; SCZ-PRS: β = 0.15, p = 0.04; MDD-PRS: β = 0.17, p = 0.01) during follow-up. PRSs for BD and ADHD were not significantly associated with any longitudinal mood variable. Conclusions: This exploratory analysis was the first to examine psychiatric PRSs in relation to the prospective course of mood symptoms among youth with BD. Results from the current study can serve to guide future youth BD studies with larger sample sizes on this topic.

Humans↗
PubMed2025

Social Responsiveness as a Mediator in Adapted Cognitive Behavioral Therapy for Autistic Youth with Maladaptive and Interfering Anxiety.

Numerous adaptations to interventions have been included in cognitive behavioral therapy (CBT) for autistic youth. This study examines the degree to which CBT adapted to the social needs of autistic youth confers significant benefit by promoting social responsiveness. A secondary analysis was conducted on a multisite randomized clinical trial (Wood et al. in JAMA Psychiatry 77:474-483, 2020) comparing adapted CBT with standard-of-practice CBT and treatment-as-usual (TA). Autistic youth (N = 167; aged 7-13) with maladaptive and interfering anxiety participated. The adapted CBT (BIACA) uses a modular format, with an emphasis on supplementing common CBT practice elements (reframing and graded exposure) with social skill supports. The primary outcome measure was the Pediatric Anxiety Rating Scale. Social responsiveness was assessed with the Social Responsiveness Scale, Second Edition. Participants' general mental health was assessed as a secondary outcome using the Brief Problem Checklist. Mediation was tested using the SPSS PROCESS macro. Analyses suggested that the effect of adapted CBT on anxiety was mediated by its effects on social responsiveness, with a statistically significant indirect effect. Youth randomly assigned to adapted CBT exhibited better overall mental health at posttreatment compared to those randomized to the other conditions, and this effect was also mediated by improved social responsiveness. CBT adapted to address some of the social needs of autistic youth may enhance mental health outcomes by supporting social responsiveness, perhaps increasing the ease and effectiveness with which some youth can navigate potentially stressful situations such as entering and participating in group activities.

Humans↗
PubMed1978

Drug use, attitudes, and behaviors of youth in an urban free clinic.

A questionnaire regarding drug use, attitudes, and behaviors was completed by youths attending a free clinic on randomly selected evenings. Compared to a sample of suburban high school youths, the clinic youths were heavier drug users and were more antiestablishment in their attitudes and behaviors. The clinic youth as a whole tended to have antiestablishment attitudes but within the sample drug use was, with specific exceptions, not related to such attitudes. Youths whose first drug was not marijuana tended to be relatively heavy users, as compared to youths who started with marijuana. Data regarding reasons for use are reported. A brief discussion focuses on society's influence on the implications with the phenomena of drug use and free clinics.

Adolescent↗
PubMed1978

Expenditures for health care of children and youth in the United States.

This paper describes the expenditures for health care in the United States in fiscal year 1975. Proportionately, health expenditures for children and youth are lower than for other age groups. The average per capita expenditure for children and youth was $212.00. For children and youth public health care expenditures represented 24 per cent of the total; from public funds, Medicaid and the Department of Defense were the largest two programs; from the public sector, the federal government provided two thirds of the total health expenditures. For children and youth, two thirds of all health expenditures were for hospital care and physicians' services.

Adolescent↗
PubMedDate not supplied

Differential patterns of drug involvement among Israeli youth.

The present study tries to link some demographic, social, psycholoogical and attitudinal variables of drug abuse. The findings were centred around the readiness of secondary school youth in Israel to be involved in drugs and their active searching for drug involvement. A dependent variable based on five indices of drug involvement was constructed. It was then related to parental control, peer involvement in drugs, sex differentiation and membership in youth movements. A bi-modal high involvement curve was found, the first mode consisting of youth of low socio-economic strata who are drop-outs, who associate with outside peer groups as an alternative to their shaky and diffused families and lack of involvement in school life. The other mode consists of youth with a higher socio-economic background who are involved with drugs due to their desire for new hedonistic and emotional experiences. Their openness to experiment with drugs is a corollary to their involvement within a peer group which condones and legitimizes narcotics as well as any experiences which irrespective of their source, provide "a good high". There is a sub-group within this group which would be involved with drugs as a partial escape from personal problems.

Adolescent↗
PubMed2026

A randomized trial of omega-3 fatty acids plus inositol versus N-acetylcysteine for the treatment of depression and mania in emotionally dysregulated youth age 5-17 with and without autism traits.

The aim of this study was to assess the effectiveness of the nutraceutical treatments combined omega-3 fatty acid plus inositol (O3I) versus N-acetylcysteine (NAC) in children and adolescents with emotional dysregulation and the impact of the co-occurrence of autism traits (AT). Participants were male and female children (5-17) with emotional dysregulation and the presence/absence of AT, as defined by Child Behavior Checklist score, randomized to receive open-label O3I (1020 mg EPA and 1000-2000 mg Inositol) or NAC (1800-2700 mg) daily for 6 weeks. Clinicians measured severity and improvement of depression and mania with the NIMH Clinical Global Improvement Scale (CGI). Parents completed Parent-Youth Mania Rating Scale (P-YMRS) and Children's Depression Inventory (CDI). Both O3I and NAC resulted in modest improvements in mania and depression and did not differ significantly in between group comparison in their effectiveness. Participants taking O3I, but not NAC, demonstrated statistically significant within group improvement in depression per CDI. Participants taking NAC had a greater decrease in P-YMRS scores versus O3I, but the difference did not reach statistical significance. In the presence of AT, NAC was more effective than O3I for mania but not for depression. Further, participants taking NAC, but not O3I, demonstrated significant within group improvement in SRS and BRIEF scores. These results suggest that O3I and NAC may be beneficial for mania and depression in youth, with trends towards O3I more effective for depression and NAC more effective for mania. The presence of AT in youth with emotional dysregulation may moderate the impact of NAC.

Humans↗
PubMed2026

Effects of Blood Flow Restriction Training at Different Levels of Arterial Occlusion Pressure on Body Composition and Athletic Performance in Youth Soccer Players: A Randomized Controlled Trial.

This study aimed to investigate the effects of low-load blood flow restriction training (BFRT) performed at different levels of arterial occlusion pressure (AOP) on body composition, maximal strength, and athletic performance in youth soccer players. Twenty-four male youth soccer players were randomly assigned to 40% AOP group, 60% AOP group, or control group. Participants in the BFRT groups performed lower-limb resistance training at 30% of one-repetition maximum (1RM) under the corresponding pressure conditions, whereas the control group trained without BFR. Training was conducted three times per week for six weeks. Body composition, back squat 1RM, countermovement jump (CMJ), T-test, and 30-m sprint performance were assessed before and after the intervention. Results showed that lower-limb muscle mass increased significantly in both the 40% AOP group (mean change = 0.55 kg, 95% CI: 0.13 to 0.97 kg, P = 0.010) and the 60% AOP group (mean change = 0.83 kg, 95% CI: 0.37 to 1.29 kg, P < 0.001), with the 60% AOP group showing significantly greater gains than the control group (between-group difference = 1.48 kg, 95% CI: 0.40 to 2.56 kg, P = 0.008). Back squat 1RM improved significantly in both the 40% AOP group (mean change = 6.50 kg, 95% CI: 3.90 to 9.10 kg, P < 0.001) and the 60% AOP group (mean change = 9.25 kg, 95% CI: 6.75 to 11.75 kg, P < 0.001), with the 60% AOP group demonstrating superior strength gains compared with the 40% AOP group (between-group difference = 2.94 kg, 95% CI: 0.20 to 5.68 kg, P = 0.048). CMJ height and T-test performance improved significantly in both the 40% AOP group (CMJ: mean change = 2.07 cm, 95% CI: 0.80 to 3.34 cm, P = 0.002; T-test: mean change = -0.23 s, 95% CI: -0.35 to -0.11 s, P = 0.001) and the 60% AOP group (CMJ: mean change = 2.65 cm, 95% CI: 1.00 to 4.30 cm, P = 0.003; T-test: mean change = -0.26 s, 95% CI: -0.38 to -0.14 s, P < 0.001), with no significant differences between the two BFRT groups (all P > 0.05). No significant changes were observed in 30-m sprint performance across groups (all P > 0.05). This study showed that six weeks of low-load (30% 1RM) blood flow restriction training performed at both 40% and 60% AOP was associated with improvements in lower-limb muscle mass, squat strength, and selected aspects of athletic performance in youth soccer players, compared with low-load training without BFR. While both pressure levels elicited comparable improvements in CMJ and agility performance, training at 60% AOP was associated with greater adaptations in lower-limb muscle mass and squat strength, with no additional benefits observed for 30-m sprint performance.

Humans↗
PubMed1977

[Methodology of out-of-school sexual-ethical education of youths (author's transl)].

The experiences of out-of-school sexual education with about 5000 youths in the district of Magdeburg are reported. The joining of a strange educator, e. g. a physician, in sexual-ethical education is always unfavourable when this is the only form of influence on youths. But at present it is still necessary to do so because of the lack of a sufficient and continuous sexual education at school. It is important here to take part in the discussion of the problems: "friendship-love-sexuality". Discussions are more effective than lectures in the usual sense. But a special course of the talk must be observed and the youths must also get the possibility of single talks. Altogether the cycle should consist of 2 discussions: -juvenile partnership -marriage and family planning.

Adolescent↗
PubMed2026

Neighborhood Hostility is Associated With the Relationship Between Park Proximity and Physical Activity Among Youth: National Evidence From Chile.

PURPOSE: Physical inactivity among youth is highly prevalent worldwide. Although proximity to parks and recreational facilities is generally associated with higher physical activity (PA), unsafe or hostile neighborhood environments may limit their use. This study examined whether neighborhood hostility moderates the association between access to recreational facilities and adherence to World Health Organization PA guidelines among Chilean youth. METHODS: This cross-sectional study analyzed data from the 2024 National Physical Activity and Sport Survey of Chile, including 3,477 urban participants stratified into childhood (5-10 years), early adolescence (11-13 years), and late adolescence (14-17 years). Built environment exposures included perceived access to recreational facilities, a cumulative neighborhood hostility score (0-5). Logistic regression models were stratified by age group and adjusted for covariates. Interaction terms assessed moderation by neighborhood hostility, and causal mediation analyses were performed. RESULTS: Adherence to World Health Organization guidelines was low (41.9% in childhood, 43.8% in early adolescence, and 43.9% in late adolescence). Greater distance to recreational facilities was associated with lower odds of meeting activity guidelines. Higher neighborhood hostility was independently associated with lower PA levels. Among adolescents, neighborhood hostility substantially attenuated the association between proximity and activity. Mediation analyses indicated partial mediation, with effective park utilization emerging as the strongest mechanism, accounting for 21.8% of the association (p < .001), followed by psychological motivation (11.9%). DISCUSSION: Proximity to recreational infrastructure alone is insufficient to promote PA in hostile neighborhoods. Policy approaches should integrate infrastructure provision with strategies addressing neighborhood safety and promoting active engagement.

Humans↗
PubMed1978

[Preventive activities of the Geneva Youth Health Service].

Based on a centralized structure and a mission oriented toward prevention, the Geneva Youth Health Service carries out extended surveillance activities in the areas of somatic health and environmental hygiene. Its services are directed at the two- to twenty-year-olds, and in particular the children and adolescents in preschool institutions, in public schools and in the technical instructional institutions. Its activities complement those of other services of the Geneva Youth Office, in particular in the medical-educational and social-educational areas.

Adolescent↗
PubMed2026

Influencer-driven lifestyle and wellness framing of intoxicating hemp products may normalize youth cannabis use.

Hemp-derived intoxicating cannabis products (DICPs) have rapidly expanded across the U.S. marketplace and are increasingly promoted on social media platforms popular among youth. This commentary highlights emerging concerns about influencer-driven DICP promotion on Instagram, where intoxicating hemp and cannabis products are embedded within lifestyle, wellness, fitness, sobriety, harm-reduction, and entertainment narratives. In ongoing monitoring of Instagram posts from leading DICP brands, we observed influencer posts that featured young-looking creators, aspirational wellness imagery, humor, slang, fast-cut editing, mocktail-making scenes, and claims positioning DICPs as "hangover-free," safer, or substitutes for alcohol or other drug use. Such content may reduce perceived risk, increase product appeal, and normalize cannabis use, particularly when promotional posts resemble organic (non-promotional) peer-culture content rather than advertising. Existing platform guidelines and regulatory approaches may inadequately address this form of influencer marketing. Enforcement is more actionable when sponsorship is clearly disclosed; however, influencers often omit brand sponsorship disclosures entirely or use vague disclosures. The absence of a disclosure does not necessarily mean that a post is non-promotional. Platforms should develop policies and algorithm-assisted surveillance approaches that identify DICP influencer content using youth-oriented cues, lifestyle and wellness framing, brand tags or links, and unverified reduced-risk or therapeutic claims.

Humans↗
PubMed1978

Intraoral air pressure during the production of /p/ and /b/ by children, youths, and adults.

Peak intraoral air pressures produced by 12 children (age four to six years), 12 youths (age 10 to 12 years), and 12 adults (age 19 to 46 years) were measured during the production of /p/ and /b/ in 12 stimulus words placed in a carrier phrase. Mean pressures produced by children and youths were similar but significantly higher than those for adults. Pressures associated with /p/ were significantly higher than those associated with /b/ across all age groups. Mean pressures associated with the intervocalic context were significantly higher than for the postvocalic context. An inverse relationship was found between age and variability of intraoral pressure, and the variability of pressure associated with /b/ was greater across all age groups than that associated with /p/.

Adult↗
PubMed1979

Factors in the drug involvement of inner city junior high school youths: a discriminant analysis.

Data from a survey of youths attending an inner city junior high school were examined to learn how their demographic characteristics, socio-cultural experiences and the drug use existing among their neighbourhood peers related to their involvement with substances. Discriminant analysis uncovered two important factors that were associated with the youths' drug taking: (1) a street scene, social/recreational drug use factor and (2) a cluster reflecting friends' use of alcohol/marijuana and other drugs. The implications of these results for drug abuse prevention programming are explored.

Adolescent↗
PubMed1978

Comparative aspects of pigmented nevi in children, youths and adults.

Clinicomorphological correlations in children of different ages, youths, and adults with various pigmented nevi are analyzed to determine the diagnostic significance of certain structures. The study included 129 pigmented nevi surgically removed from 122 children, 27 from youths, and 133 from adult subjects. A comparative analysis of the reasons that caused the removal of the pigmented nevi made it possible to clarify a number of peculiarities of pigmented nevi in children that play an important role in the clinical and diagnostic aspects, as well as the decision of management policy. For diagnostic purposes, in the evaluation of pigmented nevi in children, particular attention should not be paid to the marked cellular proliferation of junctional melanoblasts, invasion of the epidermis by nevus cells, and pigmentation of the epidermis by melanin.

Adolescent↗