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At least 19 recordsLinked to original sources
PubMed1994

Use of texture parameters in the classification of soft tissue tumors.

Soft tissue tumors are a challenging group of tumors that presents wide morphologic variety. For pathologists, the degree of cellular differentiation, the cellular and nuclear polymorphism and the mitotic rate are major criteria for diagnosis. In image analysis, the architectural organization of such tumors shows local variations that can be understood as texture variations. This study introduced a method of measuring the architectural organization of soft tissue tumors from texture analysis of tissue sections at low magnification. We studied 40 cases of soft tissue tumors classified by pathologists into three groups according to their histologic patterns. Twelve texture parameters were calculated on subimages of 128 x 128 pixels. Our results show that tissue architecture evaluated by texture analysis provides good discrimination of myxoid, spindle cell and round cell tumors.

Cell Differentiation↗
PubMed2001

Current problems in clinico-morphological assessment of soft tissue tumors.

Soft tissue tumors differ in their histology and biological behavior. Irrespectively of changing classification, different grading and staging systems of these lesions are based on similar characteristics and are of comparable clinical value. Electron microscopy, immunohistochemistry and particularly molecular biology facilitate their diagnosis, identification of new tumor entities and provide indicators for their prognosis and strategy of treatment. The new treatment modalities demand tumor characterisation before surgery, whereby sampling of tumor material is of special importance. Fine needle aspiration biopsy, apart of its limitations, is of special value in pre-treatment assessment of soft tissue tumors. Diagnosis and treatment of soft tissue tumors should be performed in cooperation between clinicians and representatives of diagnostic disciplines.

Humans↗
PubMed1992

[Magnetic resonance tomography of soft tissue tumors].

Soft tissue tumors are relatively often seen on MR tomography, although they make up a fairly small proportion of malignant lesions. To date, most soft tissue tumors have been investigated by MRI because of its unique soft tissue contrasts and its flexibility in slice orientation. But is MRI really adequate for staging and defining soft tissue tumors, or what role does it have pre-therapeutic work-up? Most malignant soft tissue tumors give rise to somewhat similar MRI findings and may not be sufficiently well characterized. On the other hand, some benign lesions can be clearly identified and staged. The goal of this paper is a critical discussion of the ability of MRI to define a lesion's degree of malignancy, to evaluate diagnostic criteria, and to describe requirements in the set-up of the investigation.

Humans↗
PubMedDate not supplied

Some characteristics of the mesenchymal stem cell of soft tissue tumors.

"Soft tissue tumors" is an unnatural term, used by clinicians and for convenience by pathologists, which unites the neoplasms of mesenchymal origin as opposed to those of the soft epithelial tissues. Not included are the reticuloendothelial system, glia and supporting tissues. The mesenchymal stem cell, the cell of the embryonal connective tissue, exhibits in man and mammals the most pronounced embryonal potential. A restricted comparison to the embryonal potential in larval and pupal cells of invertebrates, such as in hemi- or holometabolic insects and to meristematic cells in vascular plants is justified. The great embryonal potential may explain why the mesenchymal stem cell, at present a hypothetical unit, is able to transform and differentiate into the connective tissue as such, the muscular, supporting and hematogenic tissues. The musculature comprises the bulk of the mammal's body weight. The development of the normal ontogenetic specialization as well as especially those differentiations leading to soft tissue tumors are comparatively shown in this publication and placed in the framework of vertebrate and invertebrate animals with true tissues.

Animals↗
PubMed1999

The Role of Immunohistochemistry in the Diagnosis of Soft Tissue Tumors.

Soft tissue tumors may be the most diagnostically challenging lesions in pathology. Although clinical features and morphologic pattern are the gold standard for the diagnosis of soft tissue lesions, immunohistochemistry can confirm the phenotype, or resembled cell of origin, and sometimes the biologic potential of the lesion. This article discusses the role of immunohistochemistry in the diagnosis of soft tissue tumors.

Journal Article↗
PubMed2000

Recent advances in the application of immunohistochemical markers for the diagnosis of soft tissue tumors.

Soft tissue tumors represent a frequent source of diagnostic difficulty for surgical pathologists. Over the past 20 years, immunohistochemical studies have emerged as a powerful and helpful tool for the assessment and characterization of these lesions. Although much progress has been made in this field, the continuous realization of the relative lack of specificity and broad overlap in reactivity for the various tumor markers among these lesions has contributed to limit somewhat their usefulness and reliability in this area of tumor diagnosis. However, with the advent of new markers has come the new promise of better and more accurate distinction and characterization for these tumors. Herein we will review the current status of immunohistochemical tumor markers in the diagnosis of soft tissue neoplasms and address some of the more recently described antibodies and their relative value and limitations for the diagnosis of these tumors.

Antibodies↗
PubMed1988

[Classification, clinical aspects and diagnostic pathology of soft tissue tumors].

Soft tissue tumors often present a clinical problem, and their histology is heterogeneous. It is only in the last 15 years that an internationally accepted classification has been widely used to assess prognosis and determine therapy. In the present article the important clinical aspects of treatment are presented in combination with new therapeutic and diagnostic discoveries. Immunohistochemistry is now more widely used as an accepted diagnostic method than electron microscopy.

Biomarkers, Tumor↗
PubMed1998

[Significantly increased concentrations of the angiogenic growth factor bFGF in malignant soft tissue tumors].

Soft tissue sarcomas of the extremities contribute to only 0.9% of all neoplasms. Even in experienced hand radical surgical resection is followed by a recurrency rate of 7 to 35%. The reasons for this high percentage are not yet clear. Since a angiogenesis is a key factor in tumor growth we have investigated concentrations of the angiogenic peptides bFGF, TGF-beta 1, TGF-beta 2 and VEGF in systemic and tumor venous blood of 50 soft tissue sarcoma patients undergoing radical surgical tumor-resection. Systemic blood was obtained preoperatively, during surgery, 1 hour, 1 day and 1 week after surgery. 10cc of venous blood was collected from tumor veins during surgery. Levels of cytokines were measured by Sandwich-ELISA. Preoperative and intraoperative levels were significantly elevated compared to values postoperative. Concentrations of bFGF determined in tumor blood were significantly higher than serum levels but lower than controls obtained from large soft tissue wounds. VEGF and TGF were not elevated.

Endothelial Growth Factors↗
PubMedDate not supplied

[Presentation of gastric cancer as a soft tissue tumor].

Soft tissue metastasis of gastric cancer is extremely rare. We report an 82 year old male, who was being evaluated for benign prostate hyperplasia and incidentally a soft tissue mass in the right buttock was discovered. Differential diagnosis included neurofibroma vs. soft tissue sarcoma. Patient underwent surgical resection and pathologic analysis reported adenocarcinoma with ring cell differentiation. Postoperative work-up included a CT scan of abdomen and pelvis and upper gastrointestinal endoscopy. An ulcer in the gastric antrum was discovered and biopsied. Pathology reported the same tumor as the soft tissue mass. PET scan demonstrated extensive metastatic disease. We reviewed the literature looking for other cases of soft tissue metastasis of gastric cancer.

Aged, 80 and over↗
PubMed1999

Clinical Evaluation and Treatment of Soft Tissue Tumors.

Soft tissue sarcomas are uncommon and frequently missed on examination, resulting in delays in diagnosis and, occasionally, inappropriate treatment. Sarcoma staging, the process of defining the local extent of tumor and potential distant spread, involves a thorough history and physical examination, directed imaging, and biopsy. Biopsy is a complicated procedure in approximately 20% of cases and should be performed only by experienced personnel and at a center with a multidisciplinary team familiar with the treatment of patients with soft tissue sarcomas. The goal of surgery is to obtain tumor-free margins. In conjunction with radiation therapy, surgery can then provide local disease control in more than 90% of patients. The role of chemotherapy in nonmetastatic disease is unclear and is of marginal efficacy in patients with metastases. Although most tumors recur within 2 to 5 years, long-term clinical and radiographic surveillance is necessary.

Journal Article↗
PubMed2002

[New insights in the classification of soft tissue tumors].

Soft tissue tumours are rare and form some of the most difficult pathological subjects in medicine. The diagnosis of a soft tissue tumour goes hand-in-hand with a number of clinically relevant questions related to the therapy and prognosis (what is the classifying diagnosis?, is the proliferation reactive or neoplastic?; in the case of neoplasia: is it benign or malignant?, what is the grade of malignancy?, what is the expected clinical course?). Due to new insights in tumour diversity at a morphologic level, developments in immunohistochemistry and increasing (cyto)genetic knowledge about tumour-specific abnormalities, the known histological groups of tumours have been better characterised at the clinicopathological level, new tumour entities have been defined, old terms have been abandoned and a better understanding of tumour histogenesis has been established.

Diagnosis, Differential↗
PubMed1995

[Consensus soft tissue tumors. Dutch Workgroup Soft-Tissue Tumors].

Soft-tissue sarcomas constitute a rare group of malignant tumours with histopathological features of connective, muscular, fatty or peripheral nervous tissue. The prognosis at manifestation depends on only two factors: the spread, both local and remote, and the biological behaviour of the tumour. The latter factor cannot be influenced but the former can: by inexpert manipulation. Consequently, tumours suspected of being soft-tissue sarcomas require multidisciplinary management from the beginning, with the team members familiar with each other's diagnostic and therapeutic skills. Imaging diagnostic methods should precede invasive methods for collection of material for pathological examination. The number of mitotic figures observed at microscopical examination of the tissue is an important prognostic feature. Surgical resection is the treatment of first choice. Radiotherapy is indicated in grade 3 tumours, after recurrence surgery, and when radical resection would involve too much mutilation. Chemotherapy is only given in the context of clinical trials. Surgical treatment of lung metastases may be indicated in selected patients. Regional isolated perfusion with tumour necrosis factor may be an alternative for limb amputation.

Biopsy↗
PubMed2006

Histopathological outcome of 597 isolated soft tissue tumors suspected of soft tissue sarcoma: a single-center 12-year experience.

BACKGROUND: The aim of this present report was to analyze the patients referred to us with the presumptive diagnosis of soft tissue sarcoma (STS). METHODS: We reviewed all patients referred to us with suspected soft tissue sarcoma (STS) of the extremities or trunk over a 12-year period. RESULTS: We treated 597 patients with soft tissue tumors. Open biopsy revealed soft tissue sarcoma in 318 cases, benign mesenchymal tumor in 124 cases and isolated metastases (ISTM) from carcinomas in 98 patients; other pathologies were found in 57 patients. The primary carcinomas were lung cancer in 26 patients, breast cancer in 19 patients, renal carcinoma in 16 patients, carcinoma of the esophagus in 12 patients, colonic carcinoma in 5 patients, thyroid gland cancer in 6 patients, and in 14 patients carcinoma of unknown primary was diagnosed. CONCLUSIONS: In our collective with soft tissue tumor, 50% of the patients had the diagnosis of soft tissue sarcoma, 20% presented with a metastasis of carcinoma and 20% had a benign tumor. Referring to our results, in patients with the presumptive diagnosis of soft tissue sarcomas, soft tissue metastasis of a primary carcinoma was unexpectedly common, indicating that greater consideration should be given to this differential diagnosis.

Adolescent↗
PubMed2001

[Therapeutic strategies in malignant soft tissue tumors. Results of the soft tissue tumor register study of the Surgical Oncology Working Group].

INTRODUCTION: This study, carried out by the Surgical Oncology Working Group (CAO) of the German Society for Surgery, was performed to analyse the strategies in the treatment of soft tissue sarcomas in adults. METHODS: In a period of 19 months the data on 292 patients suffering from soft tissue sarcomas, treated in 99 surgical departments in Germany, were analysed prospectively. A special questionnaire was developed including pretherapeutic biopsy, previous treatment, definitive surgical treatment, combined modality approach and histopathological results. RESULTS: Thirty-nine per cent of the tumours were treated in university hospitals, 36% in medical centres, 24% in regional hospitals. During the observation period two patients were treated on average (median) by each hospital. Limb-sparing treatment was performed in 96% of the extremity tumours. There was no significant difference in the frequency of R0 resections between the different hospitals. At the university hospitals local extended operations and additive measures were used more often. The indication for adjuvant radiotherapy differed: after compartmental resection, adjuvant radiotherapy was performed in 39% of cases (19/49); after wide-excision of high-grade tumours, in 45% of cases (20/44) no adjuvant radiotherapy was necessary. In spite of less radical treatment in tumours of the trunk, additional radiotherapy was not more frequently performed. CONCLUSION: To improve the quality in the treatment of soft tissue sarcomas it seems to be of great importance to avoid inadequate initial treatment (18%), to respect the rules of oncological surgery (tumour rupture in 7% of cases), to improve the histopathological examination (no R classification in 5-12%) and to develop guidelines for multimodality treatment.

Adolescent↗
PubMed1994

[99mTc-pertechnetate scintigraphy in three cases with soft tissue tumors].

Three soft tissue tumors were studied with 99mTc-pertechnetate scintigraphy, 67Ga-citrate scintigraphy and MRI. These tumors included schwannoma, neurofibromatosis and malignant fibrous histiocytoma. On 99mTc-pertechnetate scintigram all patients showed more increased accumulation corresponding to the tumor than on 67Ga-citrate scintigram. In conclusion, 99mTc-pertechnetate scintigraphy may be useful in detection of soft tissue tumors.

Adolescent↗
PubMed1997

Modern Diagnostic Methods in Ewing's Sarcoma Family: Six Patients With Histologic Soft Tissue Tumors.

Background: Soft tissue tumors often present a major diagnostic challenge for the pathologist. The correct diagnosis has important prognostic and therapeutic consequences. In recent years significant progress has been made in identifying characteristic chromosomal abnormalities associated with certain solid tumors. More than 85% of tumors in the Ewing's sarcoma (ES) family contain a specific t(11;22) (q24;q12) translocation. Methods and Results: We present six patients with a soft tissue tumor of which only four were diagnosed primarily as belonging to the ES family. All cases were further examined by the following methods: immunohistochemistry with MIC2, cytogenetics, nested reverse transcription-polymerase chain reaction of the t(11;22), using fresh-frozen or formalin-fixed, paraffin-embedded archival material. Conclusions: This method clearly allowed the diagnosis of a tumor of the ES family in all six cases.

Journal Article↗
PubMed1979

Use of computed tomography in diagnosis of soft-tissue tumors.

Soft-tissue tumors can evade the usual diagnostic methods. In the case presented, computed tomography proved to be the best diagnostic tool in demonstrating a malignant extranodal lymphoma. Computed tomography is useful not only in detecting a tumor but also in determining its extent. This aids the surgeon in selecting and conducting the most appropriate operation.

Abdominal Neoplasms↗