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At least 19 recordsLinked to original sources
PubMed1988

Food wrenching and dodging: a neuroethological test of cortical and dopaminergic contributions to sensorimotor behavior in the rat.

Sensorimotor behavior in unilateral decorticate and unilateral dopamine-depleted rats was studied in a naturally occurring social interaction in which rats compete for food with relatively stereotyped species-typical responses. In the interaction a "robber" attempts to wrest food from a feeding "victim," which in turn protects the food by making rapid contralateral dodges. Hemidecortication abolished dodging to food wrenching attempts made by a rat approaching contralaterally to the lesion, so that the food was stolen, but recovery occurred between 15 and 60 days after surgery. Use of the side contralateral to the lesion to wrest food was moderately impaired, and recovery of food wresting was more rapid than recovery of dodging. There were no impairments in dodging to approaches to the side of the body ipsilateral to the lesion, nor were there impairments in using that side of the body to wrest food from other rats. Unilateral dopamine depletion produced dodging impairments to food-wresting attempts that were made both ipsilateral and contralateral to the side of the lesion, and the deficits endured over 60 test days. The food was frequently lost to food-wrenching attempts made contralateral to the lesion, whereas the direction of dodges to approaches ipsilateral to the lesion was reversed. Food wresting was also bilaterally impaired. In conclusion, the study shows (a) there are differences in the sensorimotor impairments that follow unilateral neocortical damage and unilateral dopamine depletion, (b) the neural organization of orienting and dodging is different, and (c) the form of the sensorimotor impairments as well as the processes of recovery can be usefully analyzed by using species-typical social interactions.

Animals↗
PubMed1992

D-1 and D-2 receptor mediation of sensorimotor behavior in rats depleted of dopamine during development.

The effects of selective D-1 and D-2 antagonists on sensorimotor behavior were studied in rats treated with 6-OHDA or its vehicle solution on either postnatal day 3, 20, or 35. Blockade of either D-1 or D-2 receptors induced akinesia and somatosensory neglect in adults treated with vehicle at any of the three ages. The behavioral effects of antagonists on rats with 6-OHDA-induced dopamine depletions varied as a function of the age at the time of damage. Adults depleted of DA on Day 35 exhibited behavioral deficits after either D-1 or D-2 blockade and at doses that were ineffective in controls. Adults depleted of DA on Day 20 exhibited deficits after either D-1 or D-2 blockade but were not any more sensitive than were controls. In contrast, adults depleted of DA on Day 3 were insensitive to the behavioral effects of D-1 or D-2 blockers but were impaired after the dual administration of both antagonists. Moreover, simultaneous administration of subthreshold doses of D-1 and D-2 antagonists produced behavioral deficits in controls and rats depleted on Day 3. These data demonstrate that activity within residual DA neurons remains critical for the expression of sensorimotor behavior in rats depleted of DA during development. However, the specific contribution of D-1 and D-2 receptors to these behaviors depends upon the animals' age at the time of depletion.

Afferent Pathways↗
PubMed2023

Human mutations in high-confidence Tourette disorder genes affect sensorimotor behavior, reward learning, and striatal dopamine in mice.

UNLABELLED: Tourette disorder (TD) is poorly understood, despite affecting 1/160 children. A lack of animal models possessing construct, face, and predictive validity hinders progress in the field. We used CRISPR/Cas9 genome editing to generate mice with mutations orthologous to human de novo variants in two high-confidence Tourette genes, CELSR3 and WWC1 . Mice with human mutations in Celsr3 and Wwc1 exhibit cognitive and/or sensorimotor behavioral phenotypes consistent with TD. Sensorimotor gating deficits, as measured by acoustic prepulse inhibition, occur in both male and female Celsr3 TD models. Wwc1 mice show reduced prepulse inhibition only in females. Repetitive motor behaviors, common to Celsr3 mice and more pronounced in females, include vertical rearing and grooming. Sensorimotor gating deficits and rearing are attenuated by aripiprazole, a partial agonist at dopamine type II receptors. Unsupervised machine learning reveals numerous changes to spontaneous motor behavior and less predictable patterns of movement. Continuous fixed-ratio reinforcement shows Celsr3 TD mice have enhanced motor responding and reward learning. Electrically evoked striatal dopamine release, tested in one model, is greater. Brain development is otherwise grossly normal without signs of striatal interneuron loss. Altogether, mice expressing human mutations in high-confidence TD genes exhibit face and predictive validity. Reduced prepulse inhibition and repetitive motor behaviors are core behavioral phenotypes and are responsive to aripiprazole. Enhanced reward learning and motor responding occurs alongside greater evoked dopamine release. Phenotypes can also vary by sex and show stronger affection in females, an unexpected finding considering males are more frequently affected in TD. SIGNIFICANCE STATEMENT: We generated mouse models that express mutations in high-confidence genes linked to Tourette disorder (TD). These models show sensorimotor and cognitive behavioral phenotypes resembling TD-like behaviors. Sensorimotor gating deficits and repetitive motor behaviors are attenuated by drugs that act on dopamine. Reward learning and striatal dopamine is enhanced. Brain development is grossly normal, including cortical layering and patterning of major axon tracts. Further, no signs of striatal interneuron loss are detected. Interestingly, behavioral phenotypes in affected females can be more pronounced than in males, despite male sex bias in the diagnosis of TD. These novel mouse models with construct, face, and predictive validity provide a new resource to study neural substrates that cause tics and related behavioral phenotypes in TD.

Preprint↗
PubMed1990

Dopamine receptors and sensorimotor behavior in MPTP-treated mice.

The contributions of dopamine (DA) receptor subtypes to sensorimotor behavior was studied in MPTP-treated mice. All DA antagonists studied produced akinesia and catalepsy in control and MPTP-treated mice. The rank order of potency was haloperidol greater than SCH 23390 much greater than L-sulpiride. Combined subthreshold doses of SCH 23390 and L-sulpiride induced marked motor impairments. Dose-response curves for each drug were shifted to the left in the MPTP-treated mice, suggesting behavioral supersensitivity. Pretreatment with the selective D1 agonist SKF 38393 or the selective D2 agonist quinpirole either alone or in subthreshold combination also prevented cold swim-induced motor deficits in the MPTP-treated animals. Haloperidol and SCH 23390 also produced somatosensory neglect in both control and MPTP-treated mice, with haloperidol greater than SCH 23390. Again, a shift of the dose-response curves to the left was observed in the MPTP-treated animals. L-Sulpiride, or another D2 antagonist spiperone, had only minimal effects on somatosensory orientation in both control and MPTP-treated mice. Our studies suggest that both D1 and D2 receptors participate in the expression of motor behavior, while D1 receptors appear to be predominantly responsible for somatosensory orientation.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine↗
PubMed2024

Human mutations in high-confidence Tourette disorder genes affect sensorimotor behavior, reward learning, and striatal dopamine in mice.

Tourette disorder (TD) is poorly understood, despite affecting 1/160 children. A lack of animal models possessing construct, face, and predictive validity hinders progress in the field. We used CRISPR/Cas9 genome editing to generate mice with mutations orthologous to human de novo variants in two high-confidence Tourette genes, CELSR3 and WWC1. Mice with human mutations in Celsr3 and Wwc1 exhibit cognitive and/or sensorimotor behavioral phenotypes consistent with TD. Sensorimotor gating deficits, as measured by acoustic prepulse inhibition, occur in both male and female Celsr3 TD models. Wwc1 mice show reduced prepulse inhibition only in females. Repetitive motor behaviors, common to Celsr3 mice and more pronounced in females, include vertical rearing and grooming. Sensorimotor gating deficits and rearing are attenuated by aripiprazole, a partial agonist at dopamine type II receptors. Unsupervised machine learning reveals numerous changes to spontaneous motor behavior and less predictable patterns of movement. Continuous fixed-ratio reinforcement shows that Celsr3 TD mice have enhanced motor responding and reward learning. Electrically evoked striatal dopamine release, tested in one model, is greater. Brain development is otherwise grossly normal without signs of striatal interneuron loss. Altogether, mice expressing human mutations in high-confidence TD genes exhibit face and predictive validity. Reduced prepulse inhibition and repetitive motor behaviors are core behavioral phenotypes and are responsive to aripiprazole. Enhanced reward learning and motor responding occur alongside greater evoked dopamine release. Phenotypes can also vary by sex and show stronger affection in females, an unexpected finding considering males are more frequently affected in TD.

Animals↗
PubMed1985

Effects of a commercial soy lecithin preparation on development of sensorimotor behavior and brain biochemistry in the rat.

Pregnant rat dams and offspring were exposed to a 5 or 2% soy lecithin preparation or a control diet. Enrichment was either lifelong beginning at gestation, limited to the time preceding, or the time following weaning, or absent (constituting a "pure" control group). The most marked early sensorimotor deficits (reflex righting and swimming development) were seen in the 5% soy lecithin preparation group, although all soy lecithin preparation-exposed offspring had elevated brain/body weight ratios and choline acetyltransferase levels. Later, animals exposed to lifelong 5 or 2% soy lecithin preparations were hypoactive, had poor postural reflexes, and showed attenuated morphine analgesia. The results indicate that dietary soy lecithin preparation enrichment during development leads to behavioral and neurochemical abnormalities in the exposed offspring.

Animals↗
PubMed1986

Critical development periods for inhibition of ornithine decarboxylase by alpha-difluoromethylornithine: effects on ontogeny of sensorimotor behavior.

The roles of ornithine decarboxylase and the polyamines in behavioral development were examined through the use of alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase. alpha-Difluoromethylornithine was administered either prenatally during gestation (days 15-17) or postnatally (days 1-20) to examine critical periods of sensitivity. Prenatal alpha-difluoromethylornithine administration resulted in a deficit in early sensorimotor ontogeny: latencies in surface righting reflex (postnatal days 1-5) and negative geotaxis (postnatal days 5-8) were prolonged, and time spent pivoting (postnatal days 7, 9, and 11) was reduced. In contrast, postnatal alpha-difluoromethylornithine primarily influenced later maturing, complex integrative behaviors such as swimming and open field activity. Thus, the behavioral effects of alpha-difluoromethylornithine exposure are highly dependent upon the age at which the drug is administered, a finding in keeping with the participation of the ornithine decarboxylase/polyamine system in cell replication and differentiation during discrete periods of neural development. The behavioral consequences of ornithine decarboxylase inhibition during these critical periods are thus related primarily both to the timetable for cellular maturation in each brain region.

Animals↗
PubMedDate not supplied

Infant rats: sensorimotor ontogeny and effects of substantia nigra destruction.

The ontogeny of sensorimotor behaviors of albino rats were evaluated from birth through adulthood (Experiment 1). Sensorimotor behaviors (e.g., visual and tactile orientation, forelimb and hindlimb hopping, righting reflexes) achieved mature (adultlike) characteristics at various ages during ontogeny and a rostral-caudal developmental pattern was revealed. In Experiment 2, the substantia nigra was bilaterally or unilaterally destroyed in rats at 10 or 25 days of age and the ontogeny of sensorimotor and regulatory (feeding, drinking, body weight regulation) behaviors were evaluated. Bilateral destruction of the substantia nigra, zona compacta, at 10 and 25 days of age resulted in transient cessation of suckling and/or feeding and drinking followed by recovery. Male brain-damaged rats had reduced body weight through 150-170 days of age. Specific feeding and drinking tests revealed the presence of residual regulatory deficits which seemed permanent. Sensorimotor testing revealed transient dysfunction for a variety of sensorimotor behaviors, with eventual recovery of normal sensorimotor capacity. The results are related to sensorimotor ontogeny and recovery from infant brain damage.

Animals↗
PubMed1988

Food wrenching and dodging: use of action patterns for the analysis of sensorimotor and social behavior in the rat.

Developments of a procedure to study two movements, food wrenching (stealing food from a conspecific) and dodging (escaping with food from a conspecific), used in the competition for food by rats is described. These include, (A) procedures for adaptation, (B) procedures for filming and scoring, and (C) procedures for measuring dimensions of movements. The character of the movements have features of action patterns in the sense that the term is used by ethologists. It is suggested that they can be used to study the neural basis of complex sequencing of behavior as well as to study the neural basis of sensorimotor behavior and sensorimotor asymmetries.

Animals↗
PubMed1979

Dissociation of active from immobility components of sexual behavior in female rats by central 6-hydroxydopamine: implications for CA involvement in sexual behavior and sensorimotor responsiveness.

Ovariectomized female rats were given a hormone treatment (2 X 8 micrograms/kg estradiol benzoate) that normally supports only low levels of lordosis responding and no soliciting behavior in tests with sexually active males. When subjected to an intraventricular 6-hydroxydopamine (6-OHDA) procedure (with pargyline pretreatment) that produced 85% and 95% depletions of caudate dopamine and cortical norepinephrine respectively, these females exhibited a dramatic increase in the intensity and frequency of lordotic responding but no soliciting behavior over 3 weekly tests. The increase in lordosis was not due to a drug- or stress-induced release of adrenal progesterone, since dexamethasone suppressed the progesterone levels, as documented by radioimmunoassay, but not the higher receptivity of 6-OHDA treated females. In other ovariectomized females given a hormone regimen (2 X 50 micrograms/kg estradiol benzoate plus 500 micrograms progesterone) that supported maximal levels of lordosis and soliciting, the same 6-OHDA treatment prolonged the average duration of lordosis while actually decreasing the incidence and duration of soliciting. The hypothesis is put forward that the differential effects of interfering with catecholamine, and more likely dopamine function on the soliciting and lordosis components of female sexual behavior might best be understood as a dissociation between mutually antagonistic behavior patterns such that responsiveness involving active orientation and forward locomotion is suppressed, whereas responses requiring immobility are augmented.

Animals↗
PubMed1978

Perinatal methadone exposure and its influence on the behavioral ontogeny of rats.

The ontogeny of spontaneous motor and sensorimotor behaviors were evaluated daily from postnatal days 2 to 19 in rats maternally exposed to methadone (5 mg/kg) throughout gestation and/or lactation. In the methadone-treated groups, the age at which a specific behavior initially appeared for any group member and the ages at which 50% and a maximal (usually 100%) number of animals demonstrated a particular behavior was often delayed several days in comparison to controls. In addition, the time interval between the age of initial appearance and maximal achievement of a positive response was protracted. Rats subjected to methadone during either gestation or lactation exhibited the most retarded behavioral development. This study demonstrates that the timetable of behavioral maturation is altered in preweaning rats perinatally exposed to methadone, with the degree of response dependent on the timing and duration of opioid treatment. In addition, these results provide a functional correlate to our earlier observations of macroscopic and neurochemical changes in the brains of methadone-treated offspring.

Aging↗
PubMed1988

'Disengage' sensorimotor deficit following apparent recovery from unilateral dopamine depletion.

Sensorimotor behavior in Long-Evans rats was evaluated acutely and chronically after unilateral dopamine depletion caused by infusions of 6-hydroxydopamine into the nigrostriatal system. In each rat, control infusions were delivered to the opposite hemisphere and a noradrenaline uptake blocker was used as a pretreatment to help protect noradrenaline cells. During the first few postoperative weeks, head movement reactions to repetitive tactile-perioral stimulation contralateral to the dopamine-depleted hemisphere were delayed but not eliminated. With recovery, facilitated by special training, the rats were able to respond quickly. However, two lasting abnormalities were observed. First, the types of head-orienting movements directed toward contralateral stimulation were different from that directed toward ipsilateral stimulation. Second, when the animals were engaged in eating behavior there was a complete failure to orient to contralateral stimulation, whereas they instantly disengaged from eating to orient to ipsilateral stimulation. When not eating, orienting was rapid and reliable to stimulation of either side of the body. These data may have implications for the role of the striatum and connected structures in the organization and integration of sensorimotor and ingestive behavior.

Animals↗
PubMed1991

Neural interactions in the frontal cortex of a behaving monkey: signs of dependence on stimulus context and behavioral state.

In order to gain an understanding of the processes taking place within and between neuronal assemblies, we made simultaneous recordings of spike trains from groups of up to 11 neurons in the frontal cortex of a rhesus monkey, that was trained to perform a sensorimotor behavioral task. We report here on preliminary results from correlation analysis of these neuronal activities, with special emphasis on signs of behaviorally induced modifications of neural interaction, possibly due to rapid modulations of discharge synchronization among the neurons. Our findings suggest that different functional groups of neurons may co-exist within each small volume of cortex, and that neurons may be dynamically recruited into such a group to fulfil a specific function.

Animals↗
PubMed1992

Age-related changes in spontaneous behavior and learning in NMRI mice from middle to old age.

Spontaneous behavior, sensorimotor reflexes and learning of 3-, 11-, 17- and 22-month-old virgin female NMRI mice were compared. Sensorimotor abilities decreased significantly from the age of 17 months in proportion to the muscular and equilibrium demand of the test. Open-field activity, hole board exploration as well as activity in the Y maze and plus maze decreased from the age of 11 months. However, in the open-field and Y maze, it was not possible to distinguish between 11-, 17- and 22-month-old mice, whereas in the plus maze, activity was drastically decreased in 17- and 22-month-old mice. In the plus maze, indices of fear-motivated behavior suggest a greater sensitivity to the situation in the age groups of 17 and 22 months. Spontaneous alternation also decreased from the age of 11 months, but at the age of 22 months, a rotational behavior emerged. Spatial learning was markedly impaired from middle age, i.e., 11 months, as indicated by longer latencies and absence of spatial bias in place learning. In cued learning, the 11- and 17-month groups eventually reached the level of the 3-month-old mice, while the 22-month age group remained impaired. Changes in swimming ability or speed did not appear to account for the swimming maze deficits. In contrast, a sensory or perceptual deficit cannot be excluded for the oldest mice.(ABSTRACT TRUNCATED AT 250 WORDS)

Aging↗
PubMed1985

Naltrexone's influence on neurobehavioral development.

The ontogeny of spontaneous motor and sensorimotor behaviors of preweaning rats, as well as ambulation, emotionality, and nociception at weaning (day 21), were studied in rats given chronic administration of 1 or 50 mg/kg naltrexone from birth to day 21. The age at which a specific spontaneous motor behavior or performance initially appeared and the age at which 100% of the animals demonstrated a particular behavior were accelerated in animals given 50 mg/kg naltrexone, but delayed in rats injected with 1 mg/kg naltrexone. In general, ambulation, emotionality, and nociceptive responses were not affected by naltrexone treatment, although the frequency of face-washing in both naltrexone groups and activity cage performance in the 50 mg/kg naltrexone group deviated from control levels. Observations of head-shake and wet-dog shake behaviors in naltrexone-treated animals at 2 hr and 10 hr post-drug injection were similar to controls with the exception of an abnormal increase in the 1 mg/kg naltrexone group at 10 hr. Although these results may imply that endogenous opioid systems play a role in regulating neurobehavioral development, further study is needed to distinguish whether these changes are a consequence of the somatic and morphological alterations known to occur with naltrexone administration or if the timetable of behavioral ontogeny is governed by endorphin-opiate receptor interaction.

Animals↗
PubMed1990

A system of personal computer control programs for tapping experiments.

A system of control and measuring programs on IBM-PC or compatible computers was developed to explore the precision and accuracy of a subject's timing mechanisms in sensorimotor behavior. Various rhythmic patterns composed of several accentuated and non-accentuated tones which the subject has to follow or to reproduce by finger tapping can be designed. All parameters of the stimulus tones, i.e., duration, pitch and inter-tone pause, in a pattern are variable. Two parallel, independent responses can be monitored simultaneously as well. In this way, the mutual influence of responses of two subjects or two responses of one subject can be analyzed. The programs are written in MODULA-2, the output data are in the ASCII format and can be processed by any common statistical package.

Data Interpretation, Statistical↗
PubMed1988

Acute stress or neuroleptics elicit sensorimotor deficits in MPTP-treated mice.

The present study evaluates the effects of MPTP-induced striatal DA depletions on sensorimotor behavior in mice. While MPTP produces no obvious behavioral deficits under normal conditions, acute stress (cold swim) or injection of low doses of haloperidol results in marked akinesia, catalepsy, and sensory neglect. Thus, significant behavioral impairments do accompany the neurotoxicity observed after MPTP administration in mice and render this a valuable animal model for studying mechanisms underlying Parkinson's disease.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine↗