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At least 19 recordsLinked to original sources
PubMed1978

[Relationship between the pathogenesis of lumbosacral radiculitis and specific treatment].

On the basis of personal experience in treating 534 patients with sacro-lumbar radiculitis the authors believe it expedient to distinguish the following clinical syndromes: lumbago, radicle neuralgia, radicle neuritis, radicle neuritis with a paralysis of the foot and the caudal syndrome. In their opinion, the main pathogenetical mechanisms of the disease, which facilitates the selection of the methods of treatment should be taken into consideration. It is stressed that a differentiated clinical approach to patients with therapeutically resistent forms of sacro-lumbar radiculitis in the majority of the cases provides good results in medicational and surgical treatment.

Diuretics↗
PubMed1979

The pathology and pathogenesis of fatal hepatic amoebiasis--A study based on 79 autopsy cases.

The present study is based on a retrospective analysis of 79 autopsy cases of hepatic amoebiasis. An attempt has been made to reconstruct the sequence of events starting from intestinal infection to invasion and transport of amoebae along the radicles of the portal veins, the formation of early Zahn's infarct and the proliferation of amoebae in such foci leading to the formation of small abscesses. The coalescence of small abscesses gives rise to the apparently large abscesses. Apart from direct contiguity, more distant extension leading to a satellite abscess is due to involvement of the hepatic and/or portal venous radicles. It seems that obstruction of the hepatic vein contributes substantially towards the enlargement of the liver and its exaggerated nutmeg appearance. Signs and symptoms of hepatic vein obstruction sometimes overshadow the abscess pathology. Thrombosis or pressure of a neighbouring abscess over the portal vein obstruction sometimes overshadow the abscess pathology. Thrombosis or pressure of a neighbouring abscess over the portal vein and bile-duct lead to development of portal hypertension and jaundice. Both cell-mediated and humoral immunity are depressed in fatal cases of hepatic amoebiasis.

Budd-Chiari Syndrome↗
PubMed2026

From dormancy to germination: Transcriptome analysis reveals the potential involvement of heat shock proteins in gibberellin-induced seed dormancy release in Solanum torvum.

Solanum torvum, a superior vegetable grafting rootstock and medicinal Solanaceae plant, exhibits strong seed dormancy, which limits its commercial cultivation. Among various strategies explored to improve the germination rate of S. torvum, exogenous application of gibberellin (GA) has been shown to be effective. In this study, a GA concentration of 2.5 mM was established as the optimal for breaking dormancy in S. torvum seeds. Transcriptome analysis of dry, water-soaked, GA-soaked, and GA-induced germinated seeds was conducted to investigate the molecular mechanism of GA-mediated dormancy release. During the soaking period, GA application significantly induced transcriptome changes in processes including protein processing, translation, and peptide biosynthesis. Concurrently, GA treatment promoted plant hormone signal transduction, enhanced DNA-binding transcription factor activity, and activated monocarboxylic acid biosynthetic process, all of which facilitated seed water absorption. Furthermore, the differentially expressed genes (DEGs) induced by GA during soaking primarily functioned in signal transduction or activation. While most of these DEGs returned to their pre-treatment expression levels before subsequent recovery, a subset persisted until seed germination. During radicle protrusion, the persistent DEGs were associated with energy metabolism and cell structure establishment. Notably, heat shock protein (HSP) genes showed dynamic expression across all stages (soaking, germination, and radicle penetration). Furthermore, by adjusting germination conditions, temperature was confirmed to be a necessary but not sufficient condition for GA-induced S. torvum seed germination. However, functional validation (e.g., using HSP inhibitors or genetic approaches) is still required to confirm the causal role of HSPs. Collectively, these findings not only clarify the molecular basis of GA-regulated seed dormancy breaking in S. torvum but also provide practical guidance for optimizing its commercial propagation protocols.

Gibberellins↗
PubMed1979

The pathology of noncirrhotic portal fibrosis: a review of 32 autopsy cases.

A wide spectrum of clinical and morphologic changes in 32 autopsy cases of noncirrhotic portal fibrosis have been described. The disease frequently occurs in younger patients with a long history of splenomegaly, usually with a history of hematemesis. Females are affected almost equally as often as males in contrast to cirrhosis. The patients tolerate the bleeding episodes well. Death is usually due to massive hemorrhage. The diagnosis is achieved through a process of exclusion. A critical analysis of hemodynamic data, a splenoportogram, liver function tests (particularly Bromsulphalein retention) and angiographic data is mandatory. Needle biopsy of the liver appears to have limited value in making the diagnosis. The gross anatomic findings vary from a nearly normal liver to gross nodularity, seen particularly on the posteroinferior surface. In some cases these nodules are seen to physically impede the portal blood flow and contribute to portal hypertension. Phlebosclerosis of the smaller radicles of the portal vein and irregular scarring are the outstanding morphologic features of the disease. These changes are usually associated with irregular dilatation of some of the larger intrahepatic branches of the portal vein as well as fibroelastosis with or without occluding or organizing thrombi in both intra- and extrahepatic branches of the portal vein. The changes in hepatic venous radicles are characterized by irregular sclerosis, which seems to contribute significantly toward postsinusoidal block in advanced cases. The probable mode of evolution is discussed.

Adolescent↗
PubMed1976

[Innervation of the medial group of plantar muscles in man (electrophysiologic study)].

The central response of the medical group of muscles in the foot sole, as a reaction to a stimulation of the tibial nerve has an antidrome character in normals over 20-22 years of age. However, in children and adolescents, as well as in disturbance of the supra-segmental control in this sort of response is a prevalent reflectory (monosynaptical) component. A similar trait was found in patients with discogenic radiculitis in an isolated lesion of the L5 radicle. And on the contrary, a pathology of the S1 radicle not only did not change the antidrome character of the response, but prevented the dominance of the reflectory component in cases of an accompanying lesion of the descending spinal conductors or L5 radical. The conclusion is made that the innervation of the protuberant muscles of the 1 finger in the human foot is accomplished by the L-motoneurons of the anterior horns of the S1 segment.

Cerebrovascular Disorders↗
PubMed1978

[Variants of transitory myeloradiculoischemic disorders].

The authors studied the development of transient disorders of blood supply in the spinal cord and radicles. Besides the well known clinical forms which are described as syndromes of intermittent claudication of the spinal cord and cauda equina, there are some other variants of this disorder. Transient ischemia of this localization as a rule is either connected with atherosclerosis of the abdominal aorta, either with degenerative-dystrophic or congenital changes in the sacral part of the spine. The authors underline the role of individual differences in the vascularization of the spinal cord in the development of disorders in spinal circulation. The prognosis of transient ischemia, its correlation with stable disturbances is assessed. A differential diagnosis is also made between different transient vascular spinal disorders and radicle disturbances.

Adult↗
PubMed1978

[Neurologic features of cervical osteokhondrosis with pseudocardiac and cardiac pain syndromes].

The authors examined 100 patients in whom cervical osteochondrosis developed with pain in the heart, intercostal, sternum area, left hand, as well as radicle, pain, vegetative and reflectory-dystrophical disturbances. The differential diagnosis between pseudocardialgia and cardialgia, on the one hand, and stenocardia, on the other, is not always simple and is based on clinical data, x-ray and ECG examinations. The basis of the pathogenesis in pseudocardialgia is the irritation of posterior sensory radicles by osteophytes or disc protrusion. Cardialgia is an incarceration and excitation of sympathical nerves, leading to disturbances in the myocardial metabolism. A comprehensive conservative treatment may give a favourable effect in the majority of patients, while indications for surgical operations are very rare.

Adult↗
PubMed1977

[Clinical picture and diagnosis of leptomeningeal sarcomatosis].

The study is based on the analysis of 10 cases of sarcomatosis of the brain and spinal pia mater. A progressive development of the disease, cachaxia, the existence of focal symptoms, radicle pain, xantochromia in the CSF, protein-cell dissociation and some other signs are characteristic of primary sarcomatosis of the pia mater. On the basis of clinical symptoms and CSF changes it is possible vitaly to perform a differential diagnosis with chronic infectious diseases and especially with tubercular meningitis and polyradiculomyelitis. Pathomorphological studies revealed tissue infiltration of the surrounding intracerebral vessels by tumors cells without proliferation into the dura mater and radicles of the spinal cord.

Adolescent↗
PubMed1976

[Somatosensory evoked brain potentials in discogenic compressions of the lumbosacral roots].

In 16 patients with discogenic lumbar-sacral radiculitis the author studied somato-sensory evoked potentials from the vertex area in response to electric stimulation of the peripheral nerves corresponding to the affected radicle on the side of the compression and on the intact side. It was established that in discogenic compressions of the radicles there is an expressed drop in the amplitude of early components of evoked potentials II1, H1, especially if the compression leads to disturbances of tacticle, double-range and deep sensitivity. The degree of changes in evoked potentials corresponds to the severity of the compression and may serve as one of the criteria for evaluating the effectiveness of conservative therapy and determination of indications to surgical treatment.

Brain↗
PubMed2026

The Spatiotemporal Genetic Architecture of Seed Vigor in Upland Cotton.

Seed vigor underpins uniform crop establishment, but its dynamic genetics are understudied. Combining high-resolution temporal phenotyping and genomics in upland cotton, we used the SeedRanger platform to record 17 image-based traits every 30 min over 120 h, revealing stage-specific heritability and identifying 541 seed-vigor loci. These loci show extensive pleiotropy and temporal coordination, forming a genetic network that preserves developmental continuity; 8.9% overlap regions under domestication selection, indicating concurrent optimization with fiber yield. Functional validation of FLA2, a candidate gene underlying a dynamic QTL, implicates auxin-mediated control of radicle elongation and cotyledon development. This temporal framework exposes dynamic genetic architecture and breeding targets for high-vigor crops.

Gossypium↗
PubMed1979

A potential pitfall of operative cholangiography in infants.

Retrograde linear extravasation of contrast media along the anatomical course of intrahepatic arborizing structures may occur during intraoperative cholangiography for evaluation of prolonged neonatal jaundice. The resultant image may mimic the appearance of intrahepatic biliary radicles.

Bile Ducts↗
PubMed1978

Extragonadal endodermal sinus (yolk sac) tumor. Angiographic findings and literature review.

The angiographic and pathologic features of an endodermal sinus tumor (EST) arising from the retroperitoneum in a 19-month-old boy are presented. Although rare instances of extragonadal origin of EST have been reported, this is the first detailed description of the angiographic abnormalities. The angiographic appearance was that of a primarily retroperitoneal tumor with parasitized feeding arteries from the liver and right kidney, early filling venous radicles, sinusoidal pooling of contrast material, and inferior vena caval obstruction.

Aortography↗
PubMed1978

Fulminant hepatic failure secondary to amebic abscesses.

A patient presented with fulminant hepatic failure which rapidly led to his death. At postmortem examination, he had several amebic abscesses secondarily infected with bacteria, one of which had ruptured intraperitoneally, and another of which had occluded major hepatic veins of the right lobe of the liver. In addition, pylephlebitis and occlusion of several right portal venous radicles were noted. Microscopic examination of the right lobe revealed marked sinusoidal congestion and large areas of infarction with severe panlobular necrosis. Fulminant hepatic failure secondary to complications of amebic abscess has been reported infrequently but should be considered in patients with this presentation who have visited or inhabited areas endemic for amebiasis.

Acute Disease↗
PubMed1978

Fast electron transfer processes in cytochrome C and related metalloproteins.

Various free radicals formed on pulse radiolysis of aqueous solutions have been used to investigate the mechanisms of reduction of cytochrome(III) c by inter- and intramolecular electron transfer. The rapid formation of free radicals (t less than 1 mus) and their high reactivity with cytochrome (k approximately 10(8)(-5) x 10(10)M(-1)s(-1)) make such studies feasible. Reduction of cytochrome by free radicls is monitored by optical methods. Fast optical changes in the 1(-500)-mus region correspond to reduction of the iron center; whereas the slower changes in the 10(-500)-ms region are attributed to postreduction conformational changes. It has been concluded that the reduction path is mediated through the crevice and that no reduction intermediates are being formed.

Cytochrome c Group↗
PubMed1978

Percutaneous transhepatic drainage catheter: a valuable therapeutic aid in obstructive jaundice.

Percutaneous decompression of the biliary system is a useful and well established procedure which can be carried out with negligible risk and may be of great benefit to the patient. The main indications are pre-operative decompression and primarily decompression of patients with inoperable obstructive neoplastic disease. In order to provide drainage, the catheter should be advanced under fluoroscopic control into one of the major radicles ore preferably into the distal common duct beyond the point of obstruction. This ideal internal drainage into the duodenum was accomplished in the reported patient with sclerosing cholangitis who was markedly improved by this procedure.

Catheterization↗
PubMed1975

Chromatin and DNA synthesis associated with nuclear membrane in germinating cotton.

The synthesis of nuclear DNA and possible attachment sites of chromatin in the cells of cotton (Gossypium barbadense) radicles during germination was investigated. Biochemical analysis of nuclear membrane fragments or Sarkosyl-magnesium-membrane complexes indicates that the DNA, including newly replicated DNA, is attached to the nuclear membranes during periods of active synthesis. Electron micrographs of nuclear membrane fragments indicate a physical association between chromatin fibers and the membranes. The attachment site appears to be proteinaceous, since the chromatin is released by protein degradative enzymes as evidenced by biochemical techniques and electron microscopic observations. Short-term labeling results in incorporation into a membrane-associated product indistinguishable from the bulk of nuclear DNA. DNA polymerase activity is also associated with nuclear membrane preparations in which [3H]thymidine triphosphate is incorporated into an acid-insoluble. DNase-sensitive product.

Cell Membrane↗
PubMed1978

Perfusion characteristics of preserved canine kidneys subjected to warm ischaemia.

Canine kidneys were subjected to 0, 15 or 30 min of warm ischaemia followed by 24 hours preservation by perfusion. Changes in perfusate concentration of acid radicles, lactate, free fatty acid and lactice dehydrogenase were assessed at 1 hour and 24 hours. With the exception of LDH concentration at 1 hour, no single parameter was capable of detecting kidneys which were so damaged as to be non-life supporting.

Animals↗
PubMed2026

Dual Roles of RAD23b and RAD4 on the Desiccation Tolerance of Germinated Seeds.

Desiccation tolerance (DT) is a survival trait enabling orthodox seeds to withstand extremely low water content. While some protective factors are characterised, it remains mechanistically obscure. Here, based on PEG-induced DT re-establishment in germinated Brassica napus L. seeds, we investigated the dual functions of nucleotide excision repair (NER) components RAD23b and RAD4 in DNA repair and transcriptional regulation of root development. PEG pre-treatment alleviated dehydration-induced DNA damage and activated NER genes, suggesting the involvement of NER in seed DT. Unexpectedly, Arabidopsis atrad23b mutant and BnRAD23b/BnRAD4 over-expressing seeds all exhibited significantly decreased DT after dry back, which evoked a hypothesis that BnRAD23b-BnRAD4 functions beyond NER. Normally, BnRAD4 interacted with BnRAD23b and repressed the expression of root development genes NAC103, EMB1444, RRA1 by directly binding to STRE elements within their promoters. Dehydration stress alleviated this repression, drove transcriptional reprogramming and might redirect the complex to execute DNA repair. Genetic analyses revealed that germinated seeds of atnac103, atemb1444, and atrra1 single mutants all exhibited reduced DT, and double mutants under atrad23b background almost abolished DT. This study suggests that RAD23b and RAD4 may regulate DT re-establishment of germinated seeds through balancing genome integrity and radicle development, with implications for DT study broadly.

Brassica napus L.↗