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At least 19 recordsLinked to original sources
PubMed1976

[Histology and histochemistry of the seal ovaries and the age-related changes in the ovaries of the Greenland seal].

Histological and histochemical methods were used to study the ovaries of Greenland seal (Pagophoca groenlandica) from birth-time up to 30 years of age and mature females of Phoca vitulina and Erignathus barbatus. The ovary of the new-born Greenland seal has fetal medullary substance which is a provisory endocrinous gland producing not only sex hormones but also corticosteron. In other species of seals the intestinal cells of the medullary substance are the equivalent of this gland. Within 3-4 weeks after birth the reduction of the fetal medullary substance is completed, it is substituted by the connective tissue and the ovary acquires its typical structure. The rest of the fetal medullary substance is in the depth of the cortex and near the infundibulum of the ovary as lipofuscincontaining cells. When the maturation period approaches, the process of the follicle atresia regularly changes: the epithelium dies quicker, and the multiplication of intestinal cells increases. The ovaries of seals are rich in interstitial cells. Their amount cyclically changes. The cells producing steroid hormones always well hydrolize AS naphthyl-phosphates, the reaction with glycerophosphate is more variable. The connective tissue is poor in acid mucopolysaccharides, its amorphous substance in the ovary cortex is rich in protein. Senile changes of the ovary are noticed in the seal beginning from 20 years of age.

Age Factors↗
PubMed1976

Status of the contralateral ovary in encapsulated low grade malignant tumors of the ovary.

The incidence of bilateral involvement in carcinoma of the ovary is shown to be relatively high. This is true for the different histologic type of malignant lesions and even when the ovary is grossly normal in appearance and on palpation. Only when carcinoma of the ovary is low grade, intracystic, unruptured and nonadherent and is in a young woman desirous of childbirth can it be managed conservatively.

Adenocarcinoma↗
PubMed1979

The silent ovary: a five year survey of cancer of the ovary at the Hutt Hospital 1973-1977.

Cancer of the ovary is the leading cause of death from gynaecological cancer. Forty-six cases are reported to re-emphasise certain features. These include the short history and the high mortality rate regardless of what treatment is used. Whereas improvement has occurred in the treatment of cancer of the corpus and the cervix, there has been no improvement over two decades in cancer of the ovary. The moral of this tale, is to advise your women folk to avoid cancer of the ovary.

Adolescent↗
PubMed1977

Histological examination of ovaries and uteri from cows with cystic ovaries.

Sections were cut from 486 cysts taken from 260 pairs of cystic ovaries which had been collected during an abattoir survey. The linine of the cysts was examined for the presence of granulosa, basement membrane, theca and luteinisation. Sections of the uteri were examined and the nature of the surface epithelium, the thickness of the endometrium and the activity of the uterine glands were recorded. In those cysts associated with a corpus luteum both granulosa and luteinisation were seen less often than in other cysts. Of the 486 cysts examined 111 (22-84 per cent) had luteinisation, the others had none. Luteinisation was most often encountered when granulosa was absent. The thickness of theca was greater in cysts than in normal follicles and was thickest in thick walled cysts associated with a corpus luteum. The majority of uteri (81-9 per cent) were normal and only in 4-78 per cent was "swiss chese" dilation of the glands seen. Thirteen cases of mucometra were seen and these are discussed in detail.

Animals↗
PubMed1979

Ovaries and adrenals in murine Schistosomiasis mansoni. I. Histopathological changes of the ovaries in acute and chronic infection.

Acute and chronic infections with schistosomiasis mansoni in mice were found to cause a reduction of the ovarian weight and atrophy of the corpus luteum cells, followed by lymphocytic and stroma cell infiltration. Finally, the corpora lutea disappeared completely. Acute schistosomiasis caused arrested development of the corpora lutea. Both acute and chronic schistosomiasis led to the formation of "wheel cells" in the interstitial tissue of the ovaries. A threshold level of intensity of disease was found to be necessary for these pathological changes. With less severe schistosomiasis, the morphology of the corpora lutea remained normal. The more intensive and long-lasting the infection, the greater became the atrophy of corpora lutea. The various factors which could have caused these pathological alterations are discussed in the light of available literature, and it is suggested that a pituitary hypofunction, and particularly a lack of luteinizing hormone effect, may play a role in the pathological transformation of the ovarian tissue.

Acute Disease↗
PubMed1979

Ovaries and adrenals in murine Schistosomiasis mansoni. II. Some observations on the function of the ovaries in acute infection.

In mice with acute schistosomiasis mansoni the mean serum level of progesterone, as determined by radioimmunoassay, was significantly lower than in non-infected control animals, probably due to the atrophy of corpora lutea and the discontinuance of their development described in an earlier paper. In spite of the histopathological changes in the ovaries and the decreased level of progesterone in the blood, estrus was present in some infected animals.

Animals↗
PubMed1979

Histologic study of ovaries from young women with endometrial adenocarcinoma.

A histologic study of 15 ovaries from patients in whom endometrial adenocarcinoma developed before the age of 40 years was performed. These ovaries were randomized with control groups of 21 age-matched normal ovaries and 25 ovaries from patients who had Stein-Leventhal syndrome. The study was done in an attempt to determine whether the ovaries from these young patients showed any histologic feature that would indicate abnormal ovarian function resulting in unopposed estrogenic stimulation of the endometrium. Histologic features assessed included type and size of cysts, presence and number of primary follicles, corpora lutea, corpora albicantia, and presence of stromal luteinization and sclerosis. Analysis of the results indicated that from a histologic point of view ovaries of patients less than 40 years old who have endometrial adenocarcinoma are more similar to normal ovaries than to polycystic ovaries. Only 11.1% of ovaries of the study group had features suggestive of polycystic ovarian disease.

Adult↗
PubMed1979

Pattern of follicular growth and steroidogenesis in the ovary of aging cycling rats.

Prior to the cessation of reproductive cycles, older female rats exhibit irregular and prolonged cycles due to alterations in the hypothalamic-pituitary-ovarian axis. In order to evaluate the age-related changes in the ovary, the histology, and estradiol, testosterone and progesterone concentrations within the ovaries of mature regular cycling (4--5 mo. old) and older irregular cycling (10--11 mo. old) rats were examined. At estrus, the number of non-atretic growing follicles (150--300u in diameter) was greater in the mature than in the older rats (18 +/- 1.5 vs 4.5 +/- 1.4). However, the number of preovulatory follicles on proestrus did not differ (6.0 +/- 1.2 vs 5.5 +/- 0.6). Estradiol, testosterone and progesterone concentrations on proestrus in mature rats averaged 38.8 pg, 56.1 pg, and 1.0 ng/ml of ovary, respectively. In the older proestrous rat, only estradiol was altered, increasing to 124.3 pg/mg. In addition, many of the preovulatory follicles within the aged ovary were larger (greater than 600u in diameter) than those within the mature ovary. On the day of estrus virtually all preovulatory follicles ovulated in the mature rat, whereas large follicles, less than or equal to 600u in diameter, remained in the older ovary. In addition, estradiol levels remained elevated and ovarian cysts were observed in the aged ovary. Thus, in the older irregular cycling rat, 1) pre-ovulatory follicles develop, but many do not ovulate; 2) these non-ovulatory follicles form ovarian cysts which remain within the ovary. The number of cysts may increase with age until a polycystic ovary develops and the rat enters a constant estrous state.

Aging↗
PubMed1979

Between-ovary interaction in the regulation of follicle growth, corpus luteum function, and gonadotropin secretion in the primate ovarian cycle. III. Temporal and spatial dissociation of folliculogenesis and negative feedback regulation of tonic gonadotropin release after luteectomy in rhesus monkeys.

This study was designed to examine effects of previous ovarian status on subsequent follicle growth and the role of between-ovary communication in the regulation of folliculogenesis and gonadotropin secretion during the primate ovarian cycle. Responses to luteectomy were compared in two groups of rhesus monkeys. In the first, follicle growth and corpus luteum function had been constrained chronically to a single ovary by hemiovariectomy performed 66--258 days earlier; the second group was composed of intact monkeys that underwent contralateral wedge resection at luteectomy. In each group, luteal ablation was followed by a prompt fall in serum progesterone levels, a premature onset of menses, and the next preovulatory gonadotropin surges 14.7 +/- 1.1 or 15.4 +/- 1.4 days later (mean +/- SE; P greater than 0.25). Although the patterns of circulating estradiol before and after ablation in each group were superimposable, luteectomy in monkeys lacking a contralateral ovary was followed by a large (2- to 4-fold) and prolonged (7--10 days) increase in serum FSH, whereas in monkeys with two ovaries, serum FSH levels exhibited only a small short-lived rise. The findings indicate that 1) prior chronic constraint of ovarian function to a single ovary did not alter the overall time course of new follicle growth culminating in ovulation after luteectomy; 2) the contralateral ovary provided the principal negative feedback regulation of gonadotropin secretion for some time after luteectomy even though it may not have been the exclusive site of new follicle growth; 3) whereas the ability of the luteectomized ovary to regulate tonic gonadotropin secretion was temporarily impaired, its ability to support the customary temporal pattern of follicle growth after luteal ablation was not; 4) some (contralateral) ovarian factor other than estradiol or progesterone apparently made a major contribution to the regulation of FSH secretion after luteectomy; and 5) folliculogenesis culminating in ovulation from a single follicle and the negative feedback regulation of tonic gonadotropin secretion in some circumstances may occur concurrently but separately on opposite ovaries or may occur at different times within the same ovary.

Animals↗