Relative radiation dosage in renal diagnostic modalities.
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Diagnostic Imaging↗
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Diagnosis of sellar and parasellar lesions by computed tomography and other diagnostic modalities.
A review of 5,000 computed tomographic (CT) brain scans revealed 76 patients with proved pathology involving the sellar and parasellar areas. The overall diagnostic accuracy of CT scanning was 93.4%, whereas the accuracy of isotope scanning, angiography, and pneumoencephalography was 55.4, 81 and 100% respectively. The criteria used in making the diagnosis with CT scanning are listed. The results indicate that CT scanning is the initial diagnostic procedure of choice, but that other modalities, particularly angiography, are still required for more accurate evaluation in the majority of cases.
Cerebral Angiography↗
Correlation of arthroscopy with other diagnostic modalities.
In our experience arthroscopy proved to be the most reliable method of evaluating internal derangement of the knee. Among 96 patients who underwent arthrotomy, the arthroscopic diagnosis was confirmed in 96 per cent. The combined anteromedial, anterolateral, and posteromedial approaches consistently demonstrated all intraarticular disorders. We found the posterolateral approach of little benefit.
Adolescent↗
Biofilms in clinical infection: pathophysiology, diagnosis, and the evolving therapeutic landscape.
Biofilms are structured communities of microorganisms encased in a self-produced polymeric matrix that typically adhere to surfaces. Recent research, however, has revealed that non-attached aggregates share many common traits with the surface-dependent biofilms. This mode of bacterial growth provides enhanced protection against antibiotics and resistance to host immune defenses. Biofilms require higher antibiotic concentrations than those needed to inhibit planktonic bacteria, necessitating prolonged high-dose and combination therapies to achieve effective eradication. This increased resistance is attributed to multiple factors, including the protective extracellular matrix, reduced metabolic activity of bacteria within the biofilm, and also the ability of bacterial genomes to rapidly adjust in response to environmental changes. Diagnostic modalities such as sonication, tissue culture, and polymerase chain reaction-based assays currently dominate clinical diagnostics of biofilm infections due to their practicality, cost-effectiveness, and proven reliability. Recent research has led to innovative treatment strategies that target biofilm structure, enhance drug delivery, and modulate host-pathogen interactions. This review summarizes our current knowledge of biofilm formation, explores the current techniques for detecting microbial biofilms, and discusses future perspectives for advancing diagnostic and therapeutic strategies.
Biofilms↗
Aggressive ossifying fibroma of the maxilla: review of the literature and report of case.
A case of a large aggressive ossifying fibroma of the maxilla has been presented. Review of the literature shows the literature shows the difficulty in establishing a definitive diagnosis through any single diagnostic modality. Much of this is due to the confusion surrounding classification of the tumor. Adjunctive radiographic and nuclear medicine diagnostic aids were utilized, as were clinical, laboratory, and histopathologic studies, in resolving the diagnostic questions posed by this large and aggressive tumor. Surgical intervention through conservative enucleation produced few operative or postoperative difficulties and minimal residual deformity. Differentiation of ossifying fibroma from other benigh and malignant neoplasms as well as fibrous dysplasia is important in the correct management of this lesion.
Adolescent↗
Cryptorchidism and testicular neoplasia.
A retrospective review of 20 cases of testicular neoplasia in cryptorchid patients is presented. These cases serve to emphasize the need for more effective diagnosis and management of the undescended testis. The various clinical presentations, diagnostic modalities, prognostic indicators, and types of management are reviewed. Due to its inaccessibility and array of clinical presentations, the intraabdominal testies tumor continues to be a diagnostic challenge. Strict attention to diagnostic cues and adherence to the management practices presented here would hopefully result in an overall decrease in testis tumors in the post-pubertal male.
Adolescent↗
Radionuclide diagnosis of bleeding Meckel's diverticulum in children.
The preoperative diagnosis of rectal bleeding due to Meckel's diverticulum in children has major difficulties when only standard clinical and radiographic technics are utilized. During the past three years we have done 70 studies with Tc99m pertechnetate for this suspected diagnosis using scintillation camera imaging and computer analysis. Five positive cases were identified and all verified at surgery. No false positives were noted. We believe this to be a safe and available procedure that should be considered a primary diagnostic modality in the investigation of young children with suspected bleeding Meckel's diverticulum.
Child↗
Electrocardiography in myocardial infarction.
Electrocardiography is an evolving clinical diagnostic modality for detection of acute myocardial infarction. Animal studies and electrocardiographic-clinical-pathological correlations have provided experience currently used for detection and rough localization of myocardial infarcts. Additions to the conventional 12 electrocardiographic leads have been utilized to increase the diagnostic sensitivity of the ECG in the setting of myocardial infarction. Mapping of ST-segment elevation an QRS complex from several chest wall loci have been employed for purposes of quantitating serially myocardial ischemic injury and eventual necrosis. These multiple lead electrocardiographic systems have also been utilized in assessing therapeutic interventions in the Coronary Care Unit. Usefulness of standard and multiple-lead recording systems is enhanced by awareness of their limitations when applied to patients with acute myocardial infarction.
Action Potentials↗
Computed tomographic scanning and the lumbar spine. Part I: Economic and historic review.
Computed tomography represents one of the most remarkable short-term technical advances ever seen in medicine. Its recent extension to scanning of the lumbar spine promises to become its most significant extra-cranial application. The accusation has been made that CT scanning represents an expensive diagnostic modality whose cost is unjustified by its clinical value. Recent studies indicate that CT scanning is presently cost-effective and promises to become more so in the future, not only by decreasing the cost of instrumentation but also by replacing other diagnostic tests (particularly those of an invasive type) and lessening the need for exploratory surgery. CT scanning is of direct benefit to the patient because it assures that lumbar surgery is performed only after an accurate and complete diagnosis.
Cost-Benefit Analysis↗
An economic evaluation of functional genomic testing for individuals with undiagnosed rare disorders.
PURPOSE: Functional genomics (FG) approaches, such as RNA-seq and proteomics, offer a complementary diagnostic modality for individuals whose cases remain unsolved after genomic sequencing. This study evaluates the cost-effectiveness and cost-benefit of FG for individuals with suspected monogenic disorders relative to manual reanalysis of genomic data at 18 months. METHODS: A decision tree model compared the costs and outcomes of FG and 18-month reanalysis using data from two Australian Undiagnosed Disease Programs. Deterministic and probability sensitivity analysis were performed. RESULTS: With a diagnostic yield of 13%, FG enabled 4 additional diagnoses per 100 individuals tested at an additional cost of $390 (US $240), resulting in an incremental cost-effectiveness ratio of $8,550 ($5,313) and an 85% probability of being cost-effective. CONCLUSION: Functional genomics enables timely diagnosis for individuals with suspected monogenic disorders by evaluating the functional impact of variants of uncertain significance, offering an advantage over reanalyzing genomic data at 18 months. Integration into the Australian healthcare system, supported by collaborative networks and secure data-sharing infrastructure, coupled with addressing barriers to accessing funded genomic testing, could lead to an annual net benefit of up to $1.1 million ($0.7 M).
Functional genomics↗
Therapeutic angiography. Its value to the surgical patient.
Standard angiographic techniques formerly used exclusively as diagnostic modalities have been modified to serve as definitive or adjunctive therapeutic measured. The techniques include transcatheter embolization; infusion of vasoactive drugs, chemotherapeutic agents and radioactive particles; tamponade of bleeding arteries and balloon catheters; extraction of vascular foreign bodies and retained biliary tract stones and transluminal arterial dilation. These techniques have been proved effective and safe when used judiciously.
Adult↗
Mammography in symptomatic women 50 years of age and under, and those over 50.
Our experience with the use of mammography as a diagnostic aid in symptomatic women with breast complaints has been presented. One-third of all cancers were found in women 50 years of age and under. The detection of cancer by mammography in the younger age group was similar to that experienced in the older age group. Radiation exposure by mammography has diminished markedly during the last 15 years--only one-third to one rad per exposure with modern technique. Recent hysterical criticism of the use of mammography in women under 50 years of age is unwarranted in the light of current findings. This diagnostic modality should be utilized when indicated in all age groups over 30. It is probable that screening clinics should include all women over 35 years of age.
Adult↗
Disseminated intravascular coagulation and related syndromes: etiology, pathophysiology, diagnosis, and management.
Disseminated intravascular coagulation (DIC) is being recognized with increased frequency and not only are newer diagnostic modalities becoming available for this syndrome, but newer, some controversial, methods of management are also being recognized and may prove to increase survival in DIC. In addition, several syndromes classically considered separate, definitive disease entities, may actually share similar or identical pathophysiology to DIC. This review summarized current, as well as controversial aspects of etiology, pathophysiology, clinical and laboratory diagnosis, and management of DIC. In addition, a brief discussion of syndromes which may share similar or identical pathophysiology to DIC is included.
Anemia, Hemolytic↗
Ventriculography with positive contrast medium in early infancy.
42 ventriculographies (PV) were carried out in infants between 10 days and 10 months of age using positive contrast medium. Indications, technique of PV and complications are discussed; PV is compared with CT and it is concluded that PV is a simple method of clarifying the causes of a macrocephalus in infancy without great technical effort and that the roles of CT and PV are valuable diagnostic modalities which are complementary.
Arnold-Chiari Malformation↗
The role of the radiologist in acute gastrointestinal bleeding.
Angiography is valuable in the diagnostic and therapeutic management of the patient with acute gastrointestinal bleeding. It should be preceded by endoscopy in acute upper gastrointestinal bleeding, but in acute lower gastrointestinal bleeding, angiography is firmly established as the primary diagnostic modality. Although angiography is less useful in chronic gastrointestinal bleeding, it may show the underlying pathologic lesion. Vasonconstrictive and embolic therapeutic angiographic procedures are particularly valuable in the patient with multiple system disease.
Celiac Artery↗
Histiocytic lymphoma (reticulum-cell sarcoma). Report of five cases.
The subject of lymphomas is discussed and five cases seen in our Oral Surgery Department are Presented. Histiocytic lymphoma, especially of the oral regions, can present with a variety of clinical manifestations. The signs and symptoms, diagnostic modalities, and treatment are discussed and the most recent classification is included.
Aged↗
Ultrasonographic diagnosis of choroidal malignant melanoma.
During the past two decades, improvements in the resolution and reliability of instrumentation and techniques have allowed A- and B-scan ultrasonography to join direct visualization, fluorescein angiography, and radioactive phosphorus testing as primary diagnostic modalities in the evaluation of intraocular neoplasms. Because overlying opacities have no effect on the examining ultrasonographic frequencies, ultrasound has the unique ability to depict the nature of intraocular pathology when the media are optically opaque. Physics, history, instrumentation and techniques are described, and criteria for diagnosis of uveal malignant melanomas by standardized A-scan and B-scan methods are discussed and illustrated.
Adipose Tissue↗
Lymphangiography and ultrasound in management of lymphoceles.
Recent reports describe the efficacy of ultrasound in the diagnosis and management of lymphoceles. To assess the appropriate role of ultrasound and lymphangiography in the management of this entity, we reviewed our experience with 14 cases diagnosed as lymphoceles. Three patients had lymphangiography alone, 5 had lymphangiography and ultrasound, and 6 had ultrasound alone. Our analysis concludes that both diagnostic modalities have a role in management depending on the size of the lymphocele and the associated clinical setting.
Cysts↗