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At least 19 recordsLinked to original sources

Mechanism of homeostatic regulation of tissue growth and reversion of transformed cells to nonmalignancy: a yin-yang problem.

The regulation of coordinated cell growth and the development of malignancy are phenomena that are too complex to be accommodated in a narrow frame. However, on the basis of about 30 years experience with interferon and the analysis of the literature presently available, it can be suggested that: (i) normal growth is discontinuous, promoted by various growth factors; (ii) its development is downregulated by a great variety of alpha/beta interferons, which are easy to detect in rapidly growing tissues during the fetal period. Arrest of the cells in interphase could promote the expression of genetically programmed differentiation; (iii) recycling of growth is obtained by sarcolectins able to downregulate the cellular effects of interferons and to relaunch cell multiplication. To maintain harmonious growth, the synthesis and the effect of these proteins have to be in equilibrium. In transformed cells, after prolonged treatment with IFN (acting as an antioncogene), v-mos, beta interferon, and sarcolectin are continuously expressed and stay in balance. This could explain in part the stable reversion to nonmalignancy, under conditions that are reminiscent of the ancestral "Yin-Yang" principle. The review presented here is restricted to the inteferon system, whose importance in coordinated growth regulation is presently poorly defined. It can be judged, however, probably significant because of the great number of alpha isoforms existing in addition to IFN-beta, which are responsible for the activation of a number of more or less defined secondary proteins; each of these could have a more specific biological role as regards the great number of growth factors and promoters.

Animals↗

Interleukins and interferons: yin-yang modulators of PGH synthase in human macrophages.

Prostaglandin H synthase (PGHs) not only is an unstable enzyme, mainly when it is challenged with substrate, but its mRNA is one of the shortest lived species so far identified in mammalian cells. Therefore, signals regulating its level are critical for the role it plays in many cells. The expression of genes coding for PGHs appears to be under the control of polypeptide growth factors. This is in accordance with our previous data showing that a colony stimulating factor-1 (CSF-1)-like factor induces the de novo synthesis of PGHs in human monocytes, as demonstrated by immunoblotting. Here we extend this concept by showing that interleukin (IL)-1 alpha behaves as a potent inducer of PGHs in human macrophages, as indicated by the block in its action due to the addition of RNA and protein synthesis inhibitors. Interferons (IFNs) alpha and beta, however, inhibit prostanoid production in a dose-dependent fashion mainly when macrophages activated by serum are tested. Thus, the PGHs system appears to be under a fine control, CSF-1 being the main regulator during the differentiation from pro-monocyte to monocyte and from monocyte to macrophage, and IL-1 (and perhaps IL-2) as well as IFN alpha and beta, the regulators during differentiation and/or proliferation of human macrophages.

Cycloheximide↗

Theoretical foundation of Chinese medicine: a modern interpretation.

The theoretical foundation of Chinese medicine as laid down in Hwang Ti Nei Ching is presented and interpreted here in modern language and conception. Our attempt is to bring Chinese medicine in harmony with Western science. Three Yin-Yang laws are formulated based on I Ching and Nei Ching and are justified from physics, mathematics and biology. The Wu-Hsing dynamic model is explained on the basis of dynamic interactions rather than static elements. The Ching-Lo doctrine is stressed upon its apparent correlations with the autonomic nervous system. Finally, the Chi is taken to play a role in life as the fields (gravitational, magnetic, nuclear, etc.) do in the physical world.

China↗

Chinese charms in the light of cosmogony.

The two greatest powers are Heaven/Earth. As opposites, on union they generate Creative Energy. Such power is transferred to their symbols as Yang/Yin. Conceived as concrete entities, Heaven/Earth appear as Air/Earth. These possess specific qualities. Air is Moist and Hot, Earth, Cold and Dry. Thus arose four cosmic qualities. Moreover, the union between Heaven and Earth resulted in creation, first being Water. Thus arose San-Pao, the three Primordial powers, Heaven, Earth and Water. Water produced its opposite, Fire, so that there resulted four cosmic elements. Air, Earth, Water and Fire. With Yin-Yang, Heaven/Earth, in the center surrounded by eight creations as cosmic elements and cosmic qualities, there arose the symbol of cosmogony. Since water was the first creation, its symbol is best placed between Heaven and Earth. Then the symbol of cosmogony with its units representing power becomes a charm. The best charm shows water next to Heaven and then items representing qualities of Air, Earth and Water. Those that usually form a continuous series would be Earth, Water, Air, Moisture, a quality of both, Water and Air. These items are an essential feature in the makeup of a Chinese charm.

China↗

A concept of holistic ethics for the health professional.

Holistic ethics involves a basic underlying concept of the unity and integral wholeness of all people and of all nature that is identified and pursued by finding unity and wholeness within the self. Within this framework, acts are not performed for the sake of law, precedent, or social norms, but rather out of a sense of doing good freely in order to witness, identify, and contribute to unity. The development of holistic ethics involves elements of both the masculine and feminine concepts interacting and relating to one another and encompassing traditional ethical views. It is characterized in the yin-yang mode of the monad of the East and the Western concept of masculine and feminine. Holistic ethics is not an ethics that is grounded or judged either in the act performed or in the distant consequences of the act, but rather in the conscious evolution of an enlightened individual of raised consciousness who performs the act. The concern is the effect of the act primarily on the individual and his or her larger Self (that unity of which he or she is a part).

Consciousness↗

[Considerations in clinical testing--implications of urinary 17-ketosteroid sulfate and 17-hydroxycorticosteroid measurements for stress research].

With the recent increase in number of patients with stress, the search is continuing for health-indicators that can be used to determine stress reliably and quickly. These indicators rely on subjective evaluations, and the establishment of an objective method of determining stress is necessary. We have developed a method involving the determination of the 17-Ketosteroid sulfates (17-KS-S) which has proved valuable for stress research. By simultaneous measurement of both 17-KS-S and 17-hydroxycorticosteroids (17-OHCS), which have different biological significance, and which originate from the adrenal gland, an organic Yin-Yang evaluation of the adrenocortical function can be made. The two values (mainly the 17-KS-S values) are closely correlated to the biological stress state as evaluated from psychosocial factors. This method should prove to be valuable in the clinic as an objective method of determining stress.

17-Hydroxycorticosteroids↗

Acupuncture and related treatment modalities. Part I: Theoretical background.

An introduction to the therapeutic applications, history, and theory of acupuncture and several related treatment modalities is presented. The practices of acupuncture, moxibustion, acupressure, and shiatsu are described. The underlying concept of treatment of imbalances of ch'i, or life energy, is presented along with the flow of ch'i in meridians (pathways), and the theories of yin and yang, Five Elements, and Eight Principle Patterns.

Acupuncture Therapy↗

Effect of emitted bioenergy on biochemical functions of cells.

The 3-5 microns infrared spectra of the external "Qi" generated by a "Qigong" master from his palm was measured using a III-V compound semiconductor InSb detector. It was found that certain Qigong master can emit two opposite kinds of "Qi": the "facilitating" (beneficial) and "inhibiting" (destroying) "Qi". During the facilitating "Qi" emission, large amount of infrared wave were detected by a temperature rise of the air in the vicinity. When the inhibiting "Qi" was emitted, the infrared wave was absorbed from the environment resulting in a cooling of the air. The temperature rise or drop possibly reflects the fact that the blood flow to the palm was increased or decreased by dilating or constricting the blood vessels through parasympathetic or sympathetic nerves. The biochemical effects of emitted "Qi" from the same Qigong master on the human fibroblast FS-4 were investigated. The facilitating "Qi" caused 1.8% increase of the cell growth in 24 hrs, 10-15% increase of DNA synthesis and 3-5% increase of protein synthesis of the cell in a 2-hr period; while inhibiting "Qi" caused 6% decrease of cell growth in a 24 hr period, 20-23% decrease of DNA synthesis and 35-48% of protein synthesis in a 2-hr period. In addition, we found that the respiration rate of boar sperm increased 12.5-13.0% after receiving 5 min exposure in facilitating "Qi," and a decrease to 45-48% by exposure to 2-min of inhibiting "Qi." The results could be attributed to the effects of emitted "Qi" or energy containing infrared light (wave) and possibly some other types of energy.

Animals↗

[Therapy by Japanese Oriental medicine (kampo) in irritable bowel syndrome].

Guideline for the treatment of irritable bowel syndrome by Japanese Oriental Medicine (Kampo) is summarized. It is very important to notice that Kampo prescription will show its best efficacy if it is adjusted for the conditions of a patient. To diagnose ill conditions for the patient is called the process of "Sho" clarification. Sho is the ultimate diagnosis, which is the term given to summarization of diagnostic process for a patient. Conceptual criteria used for making up Sho are "Yin/Yang", "Kyo/Jitsu", and "Hot/Cold". A Kampo formula has its own position regarding these concepts. We interpret about these concepts and formulae. Another important method for making Sho diagnosis is abdominal diagnosis, which is relatively easy to learn. Certain signs in abdominal diagnosis correspond to certain formula. We explain some methods in abdominal diagnosis and the related formulae. We also comment on construction process and features of Kampo prescription.

Colonic Diseases, Functional↗

[Preliminary report of the treatment of luteal phase defect by replenishing kidney. An analysis of 53 cases].

53 patients with Luteal phase defect (LPD) were treated with different Chinese medicinal herbs at different phases of menstrual cycle. On the 5th day of the menstrual cycle, the treatment was implemented with the rationale of "nourishing the Kidney Yin, invigorating the Spleen and replenishing the Qi, promoting the blood circulation and enriching the Blood" which might promote follicular development. The principle for the postovulatory treatment was that "invigorating the Kidney and strengthening the Yang" might enhance the development of corpus luteum and maintain its function. The patients were treated for three menstrual cycles. There were significant improvement in the luteal phase of endometrium, and prolonged basal body temperature elevation in progestational stage with a tendency for normalization of the wave forms and its amplitude after the treatment. In the mid-progestational stage, the level of serum LH and PRL were reduced (P < 0.05) and that of serum progestin (P) rose significantly (P < 0.01), as compared with those before the treatment. The findings suggested that Chinese herbal medicines capable of replenishing the Kidney could regulate the hypothalamus-pituitary-ovarian axis and thus improve the luteal function. Among the 53 cases, 22 (41.5%) conceived but 68.18% of them required other measures to preserve the pregnancy.

Adult↗

Anatomy and classification of acupoints.

Acupuncture points are conceived as points on the skin reflecting visceral conditions and the sites for acupuncture treatment. In the skin, acupoints tend to show higher electric conductivity and have higher concentration of neural and vascular elements as well as mast cells. Locations of some acupoints correspond to the motor points, others to the Golgi tendon organs. There is a group of midline acupoints. Most acupoints are associated with meridians and are known as meridian points. The nature of meridians is under scientific scrutiny. For identification of canine acupoints, the human meridian nomenclature was adopted.

Acupuncture Points↗

Acupuncture atlas.

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Acupuncture Points↗

Oriental concepts of acupuncture.

This chapter introduces veterinarians to Traditional Chinese Medicine (TCM). TCM has its own unique approach to describing medical conditions. The Chinese have been able to describe naturally occurring medical phenomena accurately for thousands of years. Ancient theories and concepts allowed them to treat conditions without the knowledge we currently have of neurophysiology. The terminology used in the study of TCM will help show the difference between TCM and medicine as it is practiced in the west. TCM encompasses Qi and its functions, the Meridians, and the Five Phases. It will be shown how knowledge and application of these concepts can be used to diagnose and treat disease.

Acupuncture Therapy↗