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Results for “YEASTS/pharmacology”

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At least 19 recordsLinked to original sources
PubMed1960

The binding of mercury by the yeast cell in relation to changes in permeability.

Yeast cells exposed to mercuric chloride suffer irreversible damage to the membrane, resulting in a loss of potassium and cellular anions to the medium. The maximal loss of K(+), but not the time course of K(+) loss is related to the mercury concentration, the relationship following a normal curve on a graph of log-concentration versus effect. It is concluded that the response is all or none for individual cells, and that with increasing concentrations of metal, the threshold is exceeded in an increasing proportion of the cells. Parallel studies of the binding of mercury by the cells indicate two distinct phases, only one of which is associated with the physiological response. The binding process is relatively slow but reaches an equilibrium state. Desorption is markedly dependent on temperature. No simple stoichiometric relationship exists between the binding of mercury and the physiological response (K(+) loss).

Mercury↗
PubMed1959

Induction of the respiration-deficient mutation in yeast by various synthetic dyes.

Series of triphenylmethane and xanthene dyes were found to be effective as inducers of respiration-deficient mutation in yeast. The quantitative difference in the mutagenic effect appeared to be in close relationship to the chemical structure of the respective dyes. This survey may provide a useful clue for elucidation of the mechanism of mutagenic induction.

Cell Respiration↗