Experiments at the Willowbrook State School.
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Studies of the natural history and prevention of viral hepatitis were initiated at Willowbrook State School in 1955. During the subsequent two decades there was considerable controversy regarding the ethical aspects of these studies. The background of these studies is described in detail in historical context. This report should provide the reader with information needed to make an independent objective judgement of the ethics of the Willowbrook hepatitis studies.
From the time of Hippocrates, physicians have sworn to "abstain from all intentional wrongdoing and harm," (Lifton, 1986). They are guided by ethical principles and theories that are intended to help them in their practice of medicine and scientific research. The purpose of this paper was to define research and human subjects, to review cases of abuse, address benefits and risks of human experimentation, discuss regulations governing experiments on humans, and address ethical principles and theories regarding this type of research. Human experimentation is an important activity of great societal benefit that must be conducted in a manner consistent with basic societal beliefs and values about the rights and worth of an individual (Gray, 1975). Ethical issues in human experimentation defy definite solutions, and the problems involved in human experimentation will almost certainly continue to receive active attention in future years.
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