[A neurofibroma of the vestibule of the labyrinth].
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In a previous paper attention was drawn to the possibility of introducing the labyrinth as an organ for sound perception. Behavioural responses of the guinea pig as well as electrophysiological results in the pigeon indicated that fenestration of the labyrinth might be an alternative to cochlear implants. In this paper gross electrode electrophysiological responses to transient acoustic stimuli in the pigeon are further analysed and the influence of fenestration of the lateral canal and cochlea extirpation upon these responses was studied. The vestibular AP generated by sound stimuli could, among other things, be distinguished from the cochlear AP by its shorter latency. The dynamic range of this vestibular AP is at least 30 dB. The largest vestibular responses were obtained for stimulus frequencies below about 1.5 kHz. A simple hydromechanical model to explain the observed responses is discussed.
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The use of ENG in office practice and its use as a helpful, time-saving procedure is discussed. The following practical clinical questions are answered: 1. Is the vestibular mechanism normal or abnormal? 2. Is the vestibular pathology peripheral or central? 3. Is the peripheral disease right or left sided? Cost analysis of ENG in office practice is presented.
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The present paper describes the setting-up of a new project, sponsored by the Commission of the European Communities, to promote the study of functional histopathology of the human audio-vestibular organ. The project has the purpose of co-ordinating in Europe morphological research on the hearing and equilibrium organ and promoting the comparison of data from clinical, physiological and morphological studies in the field of hearing and equilibrium impairment. A manual (Iurato et al., 1982) has been prepared with the objectives of (1) stimulating clinicians to participate in the project, (2) encouraging the collection of audiological data for comparison with pathology, and (3) supplying clinicians with the necessary information about the technique of fixation and preparation of the specimens. The fixation procedures for the two major techniques of studying ear pathology: (1) microdissection and electron microscopy, and (2) embedding of the whole block for serial sectioning and light microscopy, are described in detail. Special paragraphs deal with the technique of fixation of the brain and with the technique of removal of the temporal bones and brain at autopsy. The instructions for delivery of the specimens and the publication rules are enclosed in the main body of the manual. Appendix 1 contains a list of the participating laboratories. Appendix 2 deals with autopsy legislation in the different European countries. Appendix 3 contains the sender's data sheet which supplies the instructions for collecting the clinical history of the patient and the audiological and vestibular data.
Studies were made on 100 pupils, recruited from occupational rehabilitation schools for the deaf in Kraków. They underwent general medical as well as specialist examinations. Deafness was found up to the age of 3 years in 75% of those examined. In 30% of the subjects, their vestibular system was paralysed, ophthalmological disorders were found in 95% of cases, neurological disturbances in 15% and pathological changes of the central nervous system in 65% of cases were recorded by EEG. We did not look for evidence that deafness causes anatomical changes in the central nervous system, but the disturbances observed nevertheless indicate a correlation with congenital or early acquired deafness.
A total of 908 patients with peripheral vestibular disorders were treated with calcium antagonists for periods of 10 to 120 days in a series of controlled clinical trials using a placebo or other medication for comparison. The cumulative analysis of the results indicates that cinnarizine, flunarizine and bencyclan have produced good clinical results, particularly in patients with vascular problems. A comparison between different doses used in different trials revealed a correlation of good clinical results to smaller doses of some of these medications.
An automatic, computerized system for analysis of the ocular movements in nystagmus, slow pursuit and saccades is presented. The performance of the system has been tested in healthy subjects, as well as in patients with peripheral or brainstem audio-vestibular disorders. The automatized procedure enables an extended application of opto-motor tests in the clinical examination of patients with suspected retrocochlear and brainstem involvement.
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