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Results for “Vaginal Neoplasms”

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At least 19 recordsLinked to original sources
PubMed1975

Significance of cervicovaginal cytology after radiation therapy for cervical carcinoma.

During follow-up examinations; 1,338 cervicovaginal cytologic smears were obtained from 254 women who had irradiation therapy for cervical cancer. These specimens were meticulously searched for the various cellular phenomena that may characterize such preparations, and some of the findings were subjectively quantitated. Correlations were made with histopathologic diagnoses, clinical findings, and results of treatment. Patients with malignant postradiation cells who were promptly treated for latent new or recurrent tumors generally responded well to treatment of the secondary tumor. The presence of malignant cells at any time after completion of therapy is an ominous sign, irrespective of the clinical status, and should lead to intensive effort to identify the site of a new or persisting lesion. The significance of dysplasia in postradiation smears is not entirely clear, and in certain instances it is difficult to distinguish severely dysplastic cells from either repair cells or malignant cells.

Adenocarcinoma↗
PubMed1979

Adenocarcinoma of the vagina in a patient with gonadal dysgenesis.

Adenocarcinoma of the vagina is an uncommon tumor. Many theories have been postulated for its etiology and tissue origin. Its occurrence in young women exposed in utero to diethylstilbestrol has pointed to estrogen influence as a possible etiologic factor. A case of adenocarcinoma of the vagina in a patient with gonadal dysgenesis is presented, and histologic and electron-microscopic observations are discussed. This patient is unique in that development of the vaginal neoplasm occurred in the absence of estrogen influence.

Adenocarcinoma↗
PubMed1979

Severe dysplasia and carcinoma in situ of the vagina.

Papanicolaou smears for early detection of carcinoma in situ of the cervix has been a well-recognized method of screening patients for over 30 years. The necessity for Papanicolaou smears following hysterectomy, especially for benign disease, has been a controversial subject. Twenty-two cases of carcinoma in situ of the vagina, over a period of 18 years, at the Huntington Memorial Hospital in Pasadena, California, are presented. Ninety-five percent of the lesions were first suspected by use of the Papanicolaou smears. Approximately half of previous hysterectomies were performed for benign disease. The various methods of treatment employed and the complications in these patients are discussed.

Carcinoma in Situ↗
PubMed1978

Squamous cell dysplasia and carcinoma in situ of the cervix and vagina after prenatal exposure to diethylstilbestrol.

Squamous cell abnormalities of the vagina and cervix were evaluated in 1424 women exposed to diethylstilbestrol (DES) in utero. The prevalence of dysplasia was 2.1% and the incidence 0.85/100 person-years of followup. The dysplastic epithelial changes were almost always mild in women with no prior history of dysplasia and was slightly more frequent in the cervix than the vagina. Severe dysplasia and carcinoma in situ (CIS) were encountered only in those subjects specifically referred because of those abnormalities. The most common problem in the diagnosis of these squamous cell changes was the misinterpretation of mature and immature metaplastic cells for dysplastic squamous cells. Discordance between biopsy and cytology was common-place in the detection and followup of dysplasia, especially when it was mild. There were no instances in the study where cytology and biopsy samples from the vagina were both abnormal concurrently. Colposcopically directed biopsies did not increase the frequency of confirmation of cytologic findings. These data suggest that both cytology and biopsy of abnormal segments of the vagina and cervix remain an integral part of the examination of the DES-exposed female during long-term follow-up studies.

Adolescent↗
PubMed1991

Management of the abnormal Pap smear.

In an outpatient protocol for management of the abnormal Pap smear, it is crucial that physicians rule out the presence of invasive disease. To that end, it is essential to acquire thorough knowledge of cervical cancer risk factors, including human papilloma virus. Physicians must also be familiar with Pap smear reporting systems and the implications of Pap smear reports. Cervical biopsy, colposcopy, and endocervical curettage are important tools in evaluation of the abnormal smear. Recent research underscores the importance of performing colposcopy to assess not only dysplasia, but also atypia and HPV changes.

Algorithms↗
PubMed1991

The use of the Pap smear in Mississippi.

Mississippi physicians participating in this survey generally followed the recommended guidelines for frequency of Pap smear screening in the general population and for high risk groups. While the participating physicians considered the presence of some sexually transmitted diseases to increase the risk of developing cervical cancer, many did not consider other STD's to place a patient at increased risk. Smoking was another risk factor that many physicians overlooked. Many Mississippi physicians also did not consider a Pap smear lacking endocervical cells inadequate. All physicians performing Pap smears need to be aware of the risk factors for the development of cervical cancer. There is a continuing controversy concerning the significance of certain Pap smear findings, the timing of colposcopic intervention, and the management of abnormal findings on these tests. Clinical decisions should be based on the newer concepts of degrees of dysplasia, cytological and descriptive findings, and the potential for rapid progression of lesions. Management of the abnormal Pap smear is the topic of another article in this issue of the Journal.

Adolescent↗