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Results for “Vaccination--complications”

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At least 19 recordsLinked to original sources
PubMed1977

[Vaccination complications after oral poliomyelitis vaccination (author's transl)].

A vaccination complication is only to be recognized if, taking into consideration the incubation time, the clinical picture coincides with that of spontaneous poliomyelitis. Apart from exceptional cases, virological studies are only of importance for the assessment if they are carried out in the acute or subacute stages. Only six out of more than 150 cases could be accepted as vaccination complications.

Adolescent↗
PubMed1990

Antibody to peptides of human myelin basic protein in post-rabies vaccine encephalomyelitis sera.

Development of neurologic complications after Semple rabies vaccine is closely linked to development of antibody to myelin basic protein (MBP). The portions of MBP against which the antibodies are directed were analyzed by enzyme immunoassay in sera and cerebrospinal fluid from 27 patients with vaccine complications. Most of the antibody was directed to regions of MBP peptides 45-89 and 90-170. There was no apparent correlation between antibody specificity for MBP peptides 1-44, 45-89 and 90-170 and the type of post-vaccinal neurologic complication. We conclude that the immunoglobulin repertoire in human B lymphocytes for responding to human MBP favors the portion of the MBP molecule containing residues 45-170.

Antibodies↗
PubMed1976

Abnormalities of cellular immune response in arthritis induced by rubella vaccination.

The rubella-specific antibody, activity the levels of immunoglobulins and complement in the serum, the number of T cells, and the nature of cell-mediated immunity as measured by lymphocyte transformation (LTF) of circulating lymphocytes in response to rubella virus and phyto-hemagglutinin (PHA) were studied in 15 children who manifested arthralgia or arthritis after parenteral immunization with HPV-77 DE/5 or RA27/3 live attenuated rubella virus vaccines. Eighteen appropriately matched subjects who developed no post-vaccine complications were included as controls. The immunoglobulins, complement, and rubella antibody levels were similar in all subjects. Although significant rubella specific cell-mediated immunity was detectable in most control subjects, the activity was markedly depressed in subjects with arthritis. The LTF activity in response to PHA was approximately equal in both groups. These findings suggest a selective depression of cell-mediated immunity to rubella virus in subjects with arthritis associated with rubella vaccination.

Adolescent↗
PubMed1975

[Possibility of the occurrence of the Shwartzman phenomenon during administration of a reacting dose of typhoid antigen through the respiratory tracts].

This work is devoted to the study of possible vaccinal complications of Schwartzmann's phenomenon type following subcutaneous injection to rabbits, sensitized by typhoid antigen, of a reacting dose of the same antigen through the respiratory tracts. The reacting dose of the antigen of 0.5; 1.0, 1.5 ml was injected to the rabbits in the form of a dry and liquid aerosol intratracheally intrapulmonary and subcutaneously. Animals to which the reacting dose of the same antigen (0.1; 0.25; 0.5; 1.0 mg) was injected intravenously served as control. Local Schwartzmann's phenomenon was reproduced after administration of all the reacting doses of typhoid antigen tested by intravenous method only. Administration of the reacting dose of the same antigen through the respiratory tracts failed to produce local Schwartzmann's phenomenon, this pointing to the difference in the reaction of rabbit organism sensitized with typhoid antigen to the administration of a reacting dose of the same antigen through the respiratory tracts, in comparison with the intravenous method.

Aerosols↗
PubMed1992

Medical considerations for the pregnant traveler.

The care of pregnant travelers requires clinical information and skills that are derived from many disciplines. Issues to be considered include the safety of both mother and fetus during commercial air travel, vigorous exercise, scuba diving, and even high-altitude trekking. Immunizations require a balanced approach to the risk of disease versus the risks of vaccine complications. Safe or treated water sources are of paramount importance to prevent unnecessary exposure to antimicrobial and antiparasitic agents during pregnancy. Malaria prophylaxis is made even more difficult by an increasingly widespread resistance of Plasmodium species to chloroquine.

Diarrhea↗
PubMedDate not supplied

[Smallpox vaccination (author's transl)].

The Author examines the reasons that have led to the discontinuance of the routine vaccination against smallpox in Italy. The epidemiology of smallpox and deaths from vaccination complications observed in Italy during the period 1952-1972 are examined.

Encephalitis↗
PubMed1976

Rubella vaccine in postpubertal women. Experience in Western Washington State.

Nearly two thousand nonimmune, postpubertal females given rubella vaccine in western Washington state in 1970 to 1974 were followed up for acute reactions, inadvertent pregnancy onset, and (776 women) seroresponse. Low-level prevaccination immunity appears to explain most of the apparent vaccine failure (11.6%). The 27 vaccine-complicated pregnancies identified resulted in 17 apparently normal infants (nine from nonimmune mothers). The remaining ten were terminated by abortion (four in nonimmune women), but no abortus yielded rubella virus. Frequency of post-vaccination complaints (largely joint-related) varied with age (higher in those over 25 years), with vaccine (higher after HPV-77-DE-5 than after Cendehill strain virus), with stage of menstrual cycle when vaccine was given, and with method of contraception.

Adolescent↗
PubMed1977

Acceptability of BCG vaccination.

The acceptability of BCG vaccination varies a great deal according to the country and to the period when the vaccine is given. The incidence of complications has not always a direct influence on this acceptability, which depends, for a very large part, on the risk of tuberculosis in a given country at a given time.

BCG Vaccine↗
PubMed1991

Child mortality after high-titre measles vaccines: prospective study in Senegal.

The use of Edmonston-Zagreb high-titre (EZ-HT) vaccine at age 6 months has been recommended for countries in which measles before the age of 9 months is a substantial cause of death, but little is known about the long-term effects of high-titre live measles vaccines given early in life. In a randomised vaccine trial in a rural area of Senegal, children were randomly assigned at birth to three vaccine groups: EZ-HT at 5 months (n = 336); Schwarz high-titre (SW-HT) at 5 months (n = 321); and placebo at 5 months followed by standard low-titre Schwarz vaccine at 10 months (standard: n = 358). All children were prospectively followed for 24-39 months in a well-established demographic surveillance system. Child mortality after immunisation was significantly higher in the two groups which received high-titre vaccines than in the group given the standard vaccine. The relative risk of death was 1.80 (95% confidence interval [CI] 1.18-2.74; p = 0.007) in the EZ-HT group and 1.51 (0.97-2.34; p = 0.07) in the SW-HT group compared with the standard group. The three vaccine groups were comparable as regards various social, family, and health characteristics, and there was no difference in mortality between children who received the standard vaccine and those who were eligible for the trial but did not take part for various reasons. The higher risk of death in the two high-titre vaccine groups remained significant in multivariate analyses. These findings suggest a need to reconsider the use of high-titre measles vaccines early in life in less developed countries.

Cause of Death↗
PubMed1976

Monitoring communicable disease: vaccination programmes.

The success of vaccination as a means of disease prevention depends on its appropriate application and its reputation with the profession and the public. Surveillance, by providing accurate information on effectiveness and the frequency and nature of hazards, is essential to this purpose. Several factors that influence the success and safety of vaccination programmes are discussed. The essential elements of a vaccine surveillance scheme are outlined with special reference to experience derived from monitoring vaccines in current use.

Antibodies, Viral↗