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Results for “Uveal Neoplasms”

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At least 19 recordsLinked to original sources
PubMed1989

Eye wall resection in the management of uveal neoplasms.

Management of intraocular tumors, specifically uveal melanoma, is a matter of controversy. The treatment of these ocular neoplasms varies from observation to enucleation, irradiation (cobalt plaque and proton-helium particle) and eye wall resection. Over the last 18 years, we have developed two techniques for surgical resection of intraocular tumors. An encircling laser photocoagulation and limited scatter photocoagulation with laser precede both procedures. The operation is performed under hypotensive anesthesia in both techniques. The external approach is used for anteriorly located tumors (ciliary body and anterior choroidal lesions) and makes use of an eye basket to stabilize the operation area. A partial dissection of the sclera is performed, then the tumor is removed en bloc with the sclera, choroid and retina. The remaining sclera is resutured to cover the resected area. A modification of this technique is used for a limited excision of choroidal and retinal tissue for the purpose of biopsy and tissue analysis. The internal approach (developed four years ago) has been successfully used for removal of malignant and benign lesions located posterior to the equator and around the optic nerve. This technique uses vitrectomy instrumentation in addition to endolaser. Detailed surgical technique and results achieved in both procedures are described.

Adult↗
PubMed1986

Diagnosis and therapeutic surgery of the uvea--Part I: Surgical technique.

Surgical techniques of iridocyclectomy, iridochoroidectomy, eye wall resection, eye wall biopsy, and ab interno retinochoridectomy are described. Surgical approaches to uveal neoplasms offer a new alternative for management of these disorders. Uveal and retinal biopsy expand our knowledge of pathological processes involved in tapetoretinal degeneration and uveitides. Additionally, both eye wall biopsy and resection provide tissue to confirm tumor diagnosis and malignancy.

Biopsy↗
PubMed1994

Cutaneous malignant melanoma with diffuse intraocular metastases.

A 63-year-old man with a history of cutaneous melanoma and a 3-month history of visual loss in his right eye presented with marked pigmentation of the anterior-segment structures, including trabecular meshwork, iris, and lens surface, with pigment dispersion in the aqueous and anterior vitreous in the right eye. Clinical examination and echography showed no evidence of an intraocular tumor although metastatic melanoma was suspected. Pathologic examination revealed numerous heavily pigmented melanoma cells throughout the anterior segment of the eye, mainly concentrated in the anterior vitreous near the ciliary body. No discrete tumor was found on multiple sections through the globe.

Anterior Eye Segment↗
PubMed1996

Anterior vs posterior intraocular melanoma. Metastatic differences in a murine model.

OBJECTIVE: To study differences in metastatic rate of anterior vs posterior ocular melanoma in a murine model. METHODS: Thirty-eight 12-week-old C57BL6 mice were inoculated into the anterior chamber (AC) or posterior compartment (PC) of the right eye with 5 x 10(5) tissue culture Queens melanoma cells per 5 microL. The right eye was enucleated 14 days after inoculation, and the animal was killed 28 days after inoculation and a necropsy was performed. The eye was evaluated for the presence of melanoma and the mean of the 10 largest nucleoli in tumor cells. Eyes with orbital invasion of the melanoma were excluded. The number of metastases was determined at necropsy. RESULTS: Melanomas grew in 30 of 38 eyes. After exclusion of 9 eyes with orbital invasion of tumor, melanoma was found in 12 mice in the AC group and 9 mice in the PC group. The metastatic rate was significantly lower for AC tumors (33%) than for PC tumors (89%) (P = .02). All AC tumors that metastasized to lungs also metastasized to ipsilateral cervical lymph nodes, and no PC tumors metastasized to ipsilateral cervical lymph nodes. The median number of pulmonary metastases per tumor was significantly smaller for AC tumors than for PC tumors (P = .01) There was a median of 0 metastases (range, 0-14) per AC tumor and 4 metastases (range, 0-38) per PC tumor. CONCLUSION: Posterior ocular melanoma metastasizes more often than anterior ocular melanoma in this murine model.

Animals↗
PubMed1983

Intraocular lymphomas. Natural history based on a clinicopathologic study of eight cases and review of the literature.

Eight patients with intraocular lymphoma were studied; all were middle-aged or elderly, usually presenting with a unilateral visual deficit. All patients also had an extraocular lymphoma with either systemic (2) or isolated central nervous system (CNS) involvement (6). When ocular symptoms preceded CNS symptoms, they presented from 11 months to 10 years earlier. Intraocular lymphoma tended to affect the eye ipsilateral to the CNS tumor either exclusively or initially, and to the greatest degree histologically. Histologic examination of intervening optic pathways revealed extension of intraocular tumor across the optic nerve into orbital leptomeninges in 3 cases. Corresponding CNS tumors showed prominent leptomeningeal involvement. All intraocular and extraocular tumors showed diffuse growth patterns with histiocytic (large cell), poorly differentiated lymphocytic or mixed lymphocytic-histiocytic subtypes. CNS tumors were detected only after onset of neurologic symptoms, and were almost always fatal, although CNS irradiation prolonged survival for years in some cases. Our data suggest that the peculiar link between intraocular and CNS lymphomas may reflect both multicentric and metastatic disease processes. The prompt recognition of intraocular lymphomas as a harbinger of extraocular tumor may prove valuable in earlier recognition and treatment of the disease.

Aged↗
PubMed1983

Neonatal neuroblastoma metastatic to the iris.

A newborn infant was found to have Stage IVS retroperitoneal neuroblastoma. Multiple iris nodules were present at birth and regressed in synchrony with the primary tumor mass as chemotherapy was administered. A summary of the ocular manifestations of neuroblastoma is presented. A discussion of the possible significance of the iris lesions in this case is given. As far as we are aware, this is the first case report of neuroblastoma metastatic to the iris.

Female↗
PubMed1994

Hürthle cell carcinoma metastatic to the uvea.

BACKGROUND: The authors present a case of Hürthle cell carcinoma metastatic to the uvea in a patient with known Hürthle cell tumor of the thyroid. The fluorescein angiogram suggested a neoplastic lesion, and the collar-button configuration resembled a malignant melanoma. However, standardized echography revealed high internal reflectivity and an irregular acoustic structure suggestive of a metastatic carcinoma. METHODS: The clinical history and examination were consistent with the diagnosis of metastatic Hürthle cell carcinoma of the eye. Results of a fine-needle aspiration biopsy and histopathology of the intraocular lesion confirmed the diagnosis. RESULTS: Because this was the patient's better-seeing eye, the tumor was treated with an 125I radioactive episcleral plaque. Over the subsequent 27 months, the lesion demonstrated a gradual regression. CONCLUSIONS: We have not found any previously reported cases of Hürthle cell carcinoma of the thyroid metastatic to the eye. The diagnosis may be confirmed safely by intraocular aspiration biopsy. The lesion is responsive to radioactive plaque application. The origin, pathology, and management of this unusual tumor are reviewed.

Adenocarcinoma↗
PubMed1998

Is there a role for heavy ion beam therapy?

The aim of this contribution is to review the radio-oncological rationale of heavy ion beam radiotherapy in the management of cancer. Protons and helium ions are being investigated because of the improved dose distributions, perhaps superior in many clinical situations to those obtainable with photons or electrons. Heavy ions also bear the advantage of superior dose distribution and may additionally provide higher biological effectivity. A substantial database of historical results supports the hypothesis that conformal radiotherapy is superior to conventional radiotherapy. For the selection of patients for ion beam therapy, the following questions have to be evaluated: Can any significant radiation morbidity by conventional treatment expected? Is the radiation morbidity caused by unintended irradiation of non-target tissue outside the planning target volume? Can the tumor control be improved due to dose escalation with less radiation morbidity? A substantial number of patients have been treated by light ion radiotherapy. There are only a few clinical trials attempting to compare conventional photon radiotherapy with light ion radiotherapy. Clinical results with heavy ions such as carbon ions seem very promising in certain tumors. However results of randomized trials are still to be seen. Clearly the control arm has to be designed to be as close as possible to the optimal photon/electron treatment methods in use. The feasibility of heavy ion treatment has been demonstrated worldwide, with more than 10,000 patients. In the near future more centers worldwide will start patient treatments. The wider availability of light ion beams for clinical use will enable the establishment of a database of clinical results and the elucidation of the role of heavy ion beams in the treatment of cancer.

Humans↗
PubMed1987

Ocular and orbital metastasis of cutaneous melanomas.

Two patients with orbital metastasis from cutaneous melanoma are described. In one patient the metastatic tumour was located in the iris, in the other one it was located in the lateral rectus muscle. Only symptomatic treatment is indicated as the term of survival is short.

Adult↗
PubMed1994

The cytological, immunocytochemical and molecular genetic analysis in diagnosis of the neoplasms of the eye, eye adnexa and orbit.

The fine needle aspiration biopsy was performed in 91 patients including 57 cases of retrobulbar tumors done under CT control. All aspirates were cytologically examined. In 21 cases immunocytochemical examination was performed in order to distinguish poorly differentiated neoplasms. In 19 cases malignant lymphoma was distinguished from pseudolymphoma. Cytological diagnosis was confirmed by histopathological examination in 77 cases /84%/. One result was false positive, 3-false negative. The value of immunocytochemical methods in differential diagnosis of poorly differentiated neoplasms was stressed.

Adolescent↗