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PubMedDate not supplied

[ATPase activity and fluorescence of myometrial actomyosin in experimental uterine inertia].

A comparative study was performed for actomyosin complexes of the female rabbit myometrium in the state of labour (actomyosin of the control) and secondary uterine inertia (actomyosin of the model). Under the secondary uterine inertia the activity of actomyosin Ca2+- and Mg2+-ATPase decreases. When pH of the medium changes, ATPase of control actomyosin has two peaks of the activity: at rH 6.0 and pH 9.0, that of the model at pH 6.0. Actomyosin of the model and control differs by a degree and rate of superprecipitation, thermal stability and structure. It is supposed that the structural changes in actomyosin under the secondary uterine inertia occur due to accumulation of the metabolism products, the level of which with this pathology is beyond the limits of the adaptation potentialities of the organism.

Actomyosin↗

PubMed1980

Trasylol in the management of abruptio placentae with consumption coagulopathy and uterine inertia.

A study was conducted on 40 patients with abruptio placentae complicated by intrauterine death of the fetus, consumption coagulopathy and uterine inertia. All patients had severe hyperfibrinolysis (FDP > 300 microgram/ml). Following correction of shock, amniotomy was performed, intrauterine pressure catheters were placed, and oxytocin infusions were begun in all cases. The diagnosis of uterine inertia was made when the cervix failed to dilate following six hours of this treatment. After diagnosing uterine inertia, 18 patients (group B) did not. All but one patient in group A showed a marked improvement in the associated consumption coagulopathy and a rapid reawakening of uterine activity with progress to spontaneous vaginal delivery. Thirteen patients in group B did not show prepartum improvement in consumption coagulopathy or a resumption of uterine activity. These patients required cesarean section. There were two maternal deaths in group B; the overall complication rate in this group was greater than in group A.

Abruptio Placentae↗

PubMedDate not supplied

[The influence of nitric oxide generation on the production of interleukins and processes of prostaglandin synthesis in fetal membranes in spontaneous parturition and uterine inertia].

62 women in 38-40 weeks gestation were examined, 37 of them had normal delivery, whereas others (25) with uterine inertia, had delivery by Cesarean section. In the fetal membranes preparations nitric oxide production, interleukins -1beta and -6, arachidonic acid content and phospholipase A2 activity (limiting the rate of prostaglandin biosynthesis) were examined. In the case of uterine inertia increase of nitric oxide generation, decrease of interleukins and arachidonic acid levels and phospholipase A2 activity was found. Modulation of nitric oxide production with inhibitors and activators allowed to emphasize the role of NO in regulation of cytokine response and control of initial stages of prostaglandins synthesis.

Arachidonic Acid↗

PubMed1989

[Changes in the biochemical indices of parturients with uterine inertia against the background of therapy].

A comparison was made of some biochemical parameters for energy metabolism, acid-base balance, blood gases and uterine contractility in parturients with uterine inertia who were on therapy with or without hyperbaric oxygenation. The presence of hypoxemia and metabolic acidosis in the parturients was found to intensify the processes of lipid peroxidation, to affect the functional status of myometrial biomembranes, to result in hyperenzymemia and disturbed tissue metabolism and lower myometrial contractility. The use of hyperbaric oxygenation in the multimodality therapy for uterine inertia was ascertained to eliminate oxygen deficiency, to increase tissue respiration, contributing to normal labor.

Acid-Base Equilibrium↗

PubMed1990

[The concentration of ionized and total calcium in the blood of female dogs with uterine inertia].

Blood values of calcium, inorganic phosphate and magnesium were estimated in 26 bitches one day before parturition, on the day of parturition and daily for 6 days post partum. In 17 of these 26 animals the diagnosis was dystocia because of uterine inertia. A comparison of calcium levels between those bitches giving birth spontaneously and those requiring assistance gave no indication that blood calcium deficiency was the cause of uterine inertia.

Animals↗

PubMed2004

[Sulprostone in the treatment of uterine inertia. Report of 60 cases].

The serious haemorrhages of the delivery still one of the first causes of maternal mortality. We report an analytical study over a period of 18 months and gathering 60 cases of haemorrhage of the delivery by uterine inertia having imposed the recourse to the sulprostone. The average age of the patients was 31 years, the average parity wasv1.9, the rate of childbirth per Caesarean was 65%. The uterine surdistension was the principal etiology of the uterine inertia. The average time of administration of the sulprostone was 10 mn. No complication related to the product was noted. The effectiveness of the treatment was observed in 93.3% of the cases, with 4 cases of failure.

Abortifacient Agents, Nonsteroidal↗

PubMed1989

[Electrostimulation of the uterus in uterine inertia].

The paper provides the results of electrostimulation application to the therapy for uterine inertia. Monopolarization current action on the cervix was shown to be beneficial in 83.34% females with abnormal labor. No negative effects of the method was found on the status of a fetus and a parturient.

Adult↗

PubMed1997

[Hemostatic sutures in post-cesarean uterine inertia].

The present report describes a new technique of uterine hemostatic bonds. These sutures are used in cases of uterine inertia with the objective of produce a useful contraction in this organ after the childbirth, these bonds are useful either in cesarean operation as in delivery. The indication for these sutures in when after the usual methods for contracting the uterus as massage, uterus compression, oxytocin, ergonovics, or calcium, we can not achieve contraction and the hemorrhage persist. We report 69 cases in which the hemostatic bonds were applied. Just in one case was not possible to control the hemorrhage and a hysterectomy was required. In 68 cases hysterectomy was avoid by using the hemostatic sutures.

Adult↗

PubMed2006

Primary uterine inertia in 27 bitches: aetiology and treatment.

OBJECTIVES: To evaluate two treatment methods in bitches with primary uterine inertia in relation to blood concentrations of oxytocin, calcium and glucose. METHODS: A prospective study where 27 bitches with primary inertia were randomly allocated to treatment groups I and II. Blood samples were collected before and after treatment. Group I was treated with a combination of intravenous calcium solutions and oxytocin and group II with oxytocin only. If unsuccessful, caesarean sections or additional medical treatment was pursued. RESULTS: Plasma oxytocin concentrations were 35+/-15 pmol/l in group I and 30+/-15 pmol/l in group II. Before treatment, the total serum calcium concentrations were 2.1+/-0.2 mmol/l in both the groups, and blood glucose values were 7.0+/-0.5 mmol/l (group I) and 7.3+/-1.4 mmol/l (group II). The number of bitches subjected to caesarean sections and the number of puppies born did not differ between the two groups. CLINICAL SIGNIFICANCE: This study indicates that low plasma oxytocin levels is a cause of primary inertia in bitches with normal serum calcium concentrations and aggravates the condition in bitches with low calcium levels. Hypoglycaemia was not observed. The outcome of labour did not differ between groups I and II.

Animals↗

PubMed1993

[Uterine defibrillation in uterine inertia. Report of 2 cases].

The uterine atony are the most common cause of postpartum hemorrhage. Manual compression and pharmacologic methods are usually used with a successful result. When pharmacologic methods fail to control hemorrhage from atony, surgical measures should be undertaken to arrest the bleeding before it becomes life-threatening. We presents the utilization of electrical uterine defibrillation in two cases with acute hemorrhage confirming the effectivity of the proceeding.

Adult↗

PubMed1989

[Dynamic biochemical indices of parturients with uterine inertia against a background of hyperbaric oxygen and drug treatment].

Acid-base balance, lactate dehydrogenase, creatine phosphokinase, hydroxybutyrate dehydrogenase, oxytocinase and the final products of peroxide oxygenation of lipids-malonate dialdehyde and antioxidant activity were studied on 60 parturients, divided into two groups as each group had 30 women. Hyperbaric oxygen treatment in combination with oxytocin was studied on uterine inertia. The control group consisted of 20 parturients with normal course of delivery.

Acid-Base Equilibrium↗

PubMed2003

Application of electron spin resonance for evaluation of the level of free radicals in the myometrium in full-term pregnancy with normal labour and uterine inertia.

In order to identify and quantify free radicals in the tissues of patients with normal physiological and pathological states of births, we developed a method to evaluate the amount of free radicals in myometrium of subplacental area and from body of uterus, using electron spin resonance spectroscopy. Analysis of the concentration of free radicals in the myometrium in full-term pregnancy with normal labour and during uterine inertia was studied. The activities of Ca2+-ATPase, cytochrome c oxidase and succinate dehydrogenase in samples of these tissues were tested too. Low free radical concentrations in these tissues were associated with disturbances in contractile activity of myometrium along with reduction of Ca2+-ATPase, cytochrome c oxidase and succinate dehydrogenase activity. There proved to be an association between the level of free radicals in the tissues and alteration in the physiological processes.

Calcium-Transporting ATPases↗

PubMedDate not supplied