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At least 19 recordsLinked to original sources
PubMed1981

[Effects of prostaglandin E1 analogue and prostaglandin F2 alpha on uterine contraction, uterine blood flow and fetal circulation in pregnant and nonpregnant rabbits (author's transl)].

Effects of PGF2 alpha and PGE1 analogue (ONO-802) on uterine contraction, uterine blood flow and fetal circulation were studied in pregnant and mature nonpregnant rabbits. Uterine and fetal blood flows were measured by photoplethysmography. Ten ng of PGs were injected into aorta abdominalis. In pregnant rabbits, 10 ng of PGF2 alpha caused a great increase in uterine contraction (i.e., intrauterine pressure), slight decrease in uterine blood flow and a transient fetal bradycardia, while 10 ng of ONO-802 caused a slight increase in uterine contraction (i.e., frequency), moderate decrease in uterine blood flow and a transient fetal bradycardia. Responses in nonpregnant rabbits to these two PGs were almost the same as those in pregnant rabbits. These results indicate the different effects of these two PGs on the uterine blood flow.

Animals↗
PubMed2002

Effects of meluadrine tartrate and ritodrine hydrochloride on oxytocin-induced uterine contraction, uterine arterial blood flow and maternal cardiovascular function in pregnant goats.

This study was designed to elucidate the effects of meluadrine tartrate on oxytocin-induced uterine contraction and maternal hemodynamics in unanesthetized, chronically instrumented pregnant goats. After the administration of meluadrine tartrate or ritodrine hydrochloride to pregnant goats, changes in heart rate (HR), arterial blood pressure (AOP), and arterial blood pH and gasses (P(O2) and P(CO2)) in the mother, as well as changes in intrauterine pressure (IUP) and uterine arterial blood flow (UBF), were measured. The escalating administration of meluadrine tartrate (0.03, 0.1, 0.3 and 1 micro g. kg(-)(1). min(-)(1)) or ritodrine hydrochloride (1, 3, 10 and 30 microg. kg(-)(1). min(-)(1)) to the maternal femoral vein caused a marked and similar inhibition in oxytocin-induced uterine contraction (a rise in IUP). By these escalating dosings, maternal HR was increased dose-dependently in both treatment groups; however, the degree of the HR increase in the meluadrine tartrate-treatment group was significantly less than that in the ritodrine hydrochloride-treatment group. Furthermore, the degree of the UBF decrease in the meluadrine tartrate-treatment group was significantly less than that in the ritodrine hydrochloride-treatment group. The present study suggests that meluadrine tartrate has a mild influence on the maternal cardiovascular function relative to the effects of ritodrine taking the potent efficacy on oxytocin-induced uterine contraction into account.

Adrenergic beta-Agonists↗
PubMed2002

Spontaneous prolonged hypertonic uterine contractions (essential uterine hypertonus) and a possible infective etiology.

The management of a pregnant woman presenting with prolonged hypertonic uterine contractions (essential uterine hypertonus) and mildly elevated temperature at term is described. Histology of the placenta, cord and membranes, following delivery, revealed evidence of chorioamnionitis, funisitis and deciduitis. Our findings raise the possibility that essential uterine hypertonus may have an infective or inflammatory component to its etiology.

Adult↗
PubMed1994

Does coupling of uterine contractions reflect uterine dysfunction?

In a cohort analytical study 47 primigravidas in spontaneous normal labour at term were divided into two groups depending on the presence or absence of coupled uterine contractions during active labour. During monitoring with a pressure-tip intra-uterine catheter, 24 patients developed coupled contractions and 23 had a normal contraction pattern. There were no statistically significant differences between the two groups with regard to maternal age, gestational age, maternal height, fetal weight, head circumference and pelvic size. Patients who developed coupled contractions had a longer duration of labour, a higher uterine activity integral and an increased incidence of caesarean section for failure to progress. Because coupling of uterine contractions may be indicative of dysfunctional uterine activity, and hence a prolonged first stage of labour, failure to progress during labour in these patients should be interpreted with caution in order to avoid the incorrect diagnosis of cephalopelvic disproportion.

Adolescent↗
PubMed1986

Breast stimulation contraction stress test: uterine contractions in the absence of oxytocin release.

The contraction stress test has been widely used to manage high-risk pregnancies. Breast-stimulated uterine contractions have been assumed to be mediated through oxytocin release. We studied 20 women undergoing a breast-stimulated contraction stress test. There was no significant increase in plasma oxytocin levels during this study in either test responders or nonresponders. These results suggest that the presence of a breast stimulation-uterine contraction reflex is not mediated by oxytocin.

Breast↗
PubMed1998

[PGF2 and the induction of the trial of labor. The prognostic value of uterine contractions].

BACKGROUND: Uterine contractions during the first hour following intracervical application of dinoprostone would show the myometrial sensitivity to prostaglandins E2 (PGE2) and could be a good practical marker of the real prospects of success of an attempt to induce labor according to the above mentioned modalities. The verification of such an hypothesis is the principal aim of this work. METHODS: The study was carried out on a group of 90 cardiotocograms recorded soon after a sample of pregnant women at term underwent labor induction by intracervical application of a gel containing 0.5 mg of PGE2 (dinoprostone). Special attention was paid to some characteristics of the cardiotocograms obtained during the first hour following administration of the gel: regularity of uterine contractions, total number of contractions, number of contractions having an intensity equal or superior to 50 mmHg, mean number of contractions during a period of 10 minutes, mean number of "effective" contractions during a period of 10 minutes, presence or absence of "excessive uterine activity" (tachysystole and/or hypersystole). RESULTS: Some cardiotocographic patterns were associated with a higher percentage of successful inductions, but the observed differences, not statistically significant, do not seem to be clinically interesting. CONCLUSIONS: However, it's not possible to exclude that a longer period of uterine contractions monitoring, perhaps lasting 2 hours instead of only 60 minutes, could lead to more useful information for the management choices.

Dinoprostone↗
PubMed1991

Do biphasic uterine contractions imply poor uterine function?

In a retrospective study of 362 cardiotocographic recordings of primigravidae in labour we found 8% biphasic or coupled uterine contractions. In augmented labour, biphasic contractions occurred almost twice as often as in spontaneous and induced labour. The duration of labour complicated with biphasic contractions was increased significantly in all types of labour. Therefore biphasic contractions may reflect uneffective uterine function. Contrary to other studies, the appearance of biphasic contractions showed no correlation with epidural analgesia and the incidence of instrumental deliveries or caesarean sections was not increased.

Analgesia, Epidural↗
PubMed2003

Uterine contraction frequency before and after successful tocolytic therapy for preterm uterine contractions.

OBJECTIVE: To examine the association between prelabor uterine contraction frequency (UCF) and the success of tocolytic therapy for preterm labor (PTL). STUDY DESIGN: Eleven centers conducted a prospective, observational study of UCF recorded between 22(0/7) and 36(6/7) weeks' gestational age or until delivery > or = 2 times/d on > or = 2 d/wk in women with singleton pregnancies with and without risk factors for preterm birth. Uterine contraction data obtained from patients diagnosed with PTL allowed comparison of mean UCF both before and after an acute episode of PTL treated with either intravenous, subcutaneous or oral tocolysis. The signed rank test was used to analyze differences in UCF before and after tocolytic therapy and between women who were or were not successfully treated with a labor-inhibiting agent. RESULTS: Of 454 enrolled women, 128 were diagnosed with PTL, and 74 were successfully treated with a labor-inhibiting agent. The mean UCF preceding PTL was not different between those women successfully treated and those who delivered as a consequence of the PTL episode. There was no difference (P = .653) in mean UCF between the week before PTL (UCF 0.60 +/- 0.8, median 0.30) and the first week of monitoring after successful tocolysis (UCF 0.82 +/- 1.4, median 0.27). CONCLUSION: The mean UCF immediately preceding PTL does not predict tocolytic success or failure.

Adult↗
PubMed2004

Effect of teasing, mechanical stimulation and the intrauterine infusion of saline on uterine contractions in mares.

Uterine motility may have significance for the transportation of spermatozoa and the elimination of the ejaculate and inflammatory products after mares have been covered. The effect of some of the component stimuli of coitus on uterine contractions was investigated by using M-mode ultrasound. The number, amplitude and duration of the uterine contractions of each uterine horn and of the uterine body were measured in oestrous mares for four minutes before and four minutes after teasing by a stallion, mechanical stimulation of the vagina and cervix, the intrauterine infusion of 80 ml of sterile saline, the intrauterine infusion of 10 ml of sterile saline, the intrauterine infusion of 150 ml of sterile saline, and the transcervical passage of a uterine catheter. Teasing by a stallion did not affect the total number, mean amplitude or mean duration of the uterine contractions. Mechanical stimulation of the vagina and cervix increased the total number of uterine contractions, but did not affect the amplitude or duration of the contractions. The intrauterine infusion of 80 ml of sterile saline resulted in an increase in the total number of contractions and a significant increase in the mean amplitude and the mean duration of the contractions in the uterine horns but not the uterine body. The intrauterine infusion of 10 ml of sterile saline caused a significant decrease in the number of uterine contractions in the uterine horns, but had no effect on the contractions of the uterine body. The infusion of 150 ml of sterile saline reduced the number of contractions in the uterine horns but not the uterine body, and did not affect the mean amplitude and mean duration of the contractions. The transcervical insertion of a catheter reduced the number of contractions in the uterine horns, but did not affect the amplitude or duration of the uterine contractions.

Animals↗
PubMed1998

Tocolytic effect of the cyclooxygenase-2 inhibitor, meloxicam: studies on uterine contractions in the rat.

The objective of this study was to assess the tocolytic activity of meloxicam, a novel cyclooxygenase-2 inhibitor, in a comparative study with the non-steroidal anti-inflammatory drug, indomethacin. The in-vitro tocolytic effect of meloxicam and indomethacin (10(-9)-10(-5)M) was evaluated on spontaneously-contracting uterine strips from non-pregnant rats and from rats at various stages of pregnancy. The rhythmic motility of the strips was reproducibly maintained over several hours. The effect of drugs was evaluated from the extent of inhibition of the frequency and amplitude of contractions. Both indomethacin and meloxicam induced dose-dependent inhibitory effects, with meloxicam being slightly more potent in all groups studied, particularly in early pregnancy. These results suggest that meloxicam, which has fewer side-effects than cyclooxygenase-1 inhibitors, could be a potentially useful tocolytic agent in the treatment of premature labour.

Animals↗
PubMed1976

A comparative study of uterine activity in labour induced with prostaglandin F2alpha or oxytocin and in spontaneous labour. I. Pattern of the uterine contractions.

The uterine contraction patterns and the changes in fetal heart rate (FHR) were studied in cardiotocographic recordings from 26 women in oxytocin-induced labour, 26 women in PGF2alpha-induced labour and 24 women during the later part of spontaneous labour. The contraction patterns and their effect on the FHR did not differ between the three groups. During the course of labour an increasing steepness of the upward slope of the contraction wave with increasing intensity of the contraction was found. High frequency of atypical contraction patterns, suggesting some degree of uterine incoordination was found during the active phase of labour in 10 patients, 8 of whom were primiparae. This incoordination could not be related to the effect of induction with either drug. Incoordinated contractions were associated with longer duration of labour and a tendency to more pronounced acidosis in the infant at birth, although mean values still fell in the normal range. Ominous FHR patterns were only seen in 2 cases of uterine hyperactivity during induction of labour.

Acidosis↗
PubMed2006

Effects of coitus and the artificial insemination of different volumes of fresh semen on uterine contractions in mares.

Uterine contractions may play an important role in the transportation of spermatozoa towards the site of fertilisation in the oviduct of mares. M-mode ultrasound was used to measure the number, amplitude and duration of uterine contractions in each uterine horn and the uterine body of oestrous mares for four minutes before and four minutes after either coitus, or the artificial insemination of either 80.0 ml of fresh semen or 10.0 ml of fresh semen. The direction of the uterine contractions in each uterine horn and the uterine body was measured before and after coitus. Coitus and the insemination of 80.0 ml semen significantly increased the total number, mean amplitude and mean duration of contractions in all parts of the uterus. The insemination of 10.0 ml of semen did not affect the total number or the mean duration of contractions in the uterine horns. Their mean amplitude was increased, but largely owing to the results from one mare; it also did not affect the contractions in the uterine body. There was no significant difference between the percentage of contractions moving in a cervicotubal or tubocervical direction after coitus in any part of the uterus examined.

Animals↗
PubMed1989

Patterns of uterine contractions and prolonged uterine activity using three methods of breast stimulation for contraction stress tests.

The contraction patterns in 378 breast-stimulated contraction stress tests administered to 213 women are described. The subjects were assigned sequentially to one of four intervention groups: bilateral manual breast massage, unilateral pump stimulation, heating pad stimulation, and placebo. There was a marked increase in the proportion of tests with three to four contractions in 5-minute intervals after the interventions occurred. Twenty-five percent of all tests showed prolonged uterine activity, occurring most frequently in women with postdate gestations using manual massage or breast pump stimulation. The duration of prolonged contractions ranged from 1.5-8 minutes, with 19% lasting from 4.5-8 minutes. There was no difference in the incidence of fetal heart rate abnormalities between tests with and without prolonged uterine activity, and no late decelerations occurred in tests with tachysystole.

Adolescent↗
PubMed1985

[Influence of arachidonic acid metabolic inhibitors upon uterine contractions].

The stimulating action of uterine contractions of cyclooxygenase products and 5-lipoxygenase products in an arachidonic acid cascade and the role of the inhibitors of both pathways have recently been the subject of much attention. We studied the influences of these drugs using the myometriums of pregnant rats. The inhibitory effects on pregnant uterine contractions (in vitro) were in the order beta 2-stimulants (procaterol, pirbuterol) greater than AA-861 greater than flurbiprofen greater than indomethacin greater than BW-755C. The inhibitory potency was reinforced by concurrent administration of AA-861 and flurbiprofen. Stimulation of the uterine contractions by Leukotriene (LT) was LTD4 greater than LTC4, and also the inhibition of the LT strain was AA-861 greater than flurbiprofen. The stimulation of PGE1 analog (ONO-802) revealed the reaction of LT + AA-861 (-) and LT + flurbiprofen (+/-). As to the changes in c-AMP and c-GMP in the bath medium before and after the administration of each drug, the change in the administration of the LT strain was slight, and an increase in c-AMP and a decrease of c-GMP were noted following the administration of contraction inhibitory substances. Its variation ratios were noted, in the order: increase in c-AMP of AA-861 + flurbiprofen greater than pirbuterol AA-861 greater than BW-755C, and decrease in c-GMP of pirbuterol greater than AA-861 + flurbiprofen greater than A-861 greater than BW-755C.

Adrenergic beta-Agonists↗