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The antimicrobial action of beta-ursolic acid (triterpenoid sapogenin from the ursan group) has been studied. At the concentration of 300 mug/ml, this substance inhibited growth of all strains of staphylococci investigated. MIC for Gram-positive bacteria ranged between 50 and 500 mug/ml, and 100 to 800 mug/ml for Gram-negative bacteria and yeasts. Acquired resistance to beta-ursolic acid was transient.
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An aqueous ethanol extract of Jacaranda caucana Pittier (Bignoniaceae) showed in vivo antitumor activity against the P-388 lymphocytic leukemia system. Fractionation, accompanied by monitoring for biological activity, afforded a novel phytoquinoid derivative jacaranone, which exhibited both in vivo antitumor and in vitro cytotoxic activity. beta-Sitosterol, betulinic acid, ursolic acid, 2alpha-hydroxyursolic acid, 2alpha,3alpha-dihydroxyurs-12-en-28-oic acid and a new triterpene acid, jacarandic acid, were also isolated. The structure elucidation of jacarandic acid is described.
Dengue infection remains a major global public health challenge, with no specific antiviral therapy currently available. The dengue virus non-structural protein 1 (NS1) exists in both intracellular and secreted forms playing a pivotal role in viral replication, immune evasion, and pathogenesis, particularly by contributing to endothelial disruption and vascular leakage during severe disease, thereby making it a promising therapeutic target. In silico screening identified berberine, betulinic acid, and ursolic acid as top candidates, exhibiting high binding affinities and stable interactions within the NS1 binding pocket. These computational predictions were further validated by biophysical assays, which demonstrated strong and specific binding interactions between the purified NS1 protein and the selected compounds. All three compounds significantly reduced viral genome levels, with the highest inhibition observed for berberine (60%), and followed by betulinic acid (40%) and ursolic acid (28%). Consistently, berberine showed the most potent inhibition of both intracellular and extracellular NS1. Overall, these findings highlight the inhibitory potential of natural compounds against DENV NS1 and provide a strong foundation for the development of NS1-targeted antivirals as a novel therapeutic strategy against dengue infection.
The chloroform extract of Vauquelinia corymbosa Correa has shown activity against the P-388 lymphocytic leukemia test system. The constituents responsible for this activity were identified as uvaol, ursolic acid, and betulinic acid. Their identity was proven by melting point; mixed melting point; elemental analysis; IR, PMR, and mass spectra; and preparation of derivatives.
A phytochemical investigation of an ethanolic extract of the whole plant of Echites hirsuta (Apocynaceae) resulted in the isolation and identification of the flavonoids naringenin, aromadendrin (dihydrokaempferol), and kaempferol; the coumarin fraxetin; the triterpene ursolic acid; and the sterol glycoside sitosteryl glucoside.