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At least 19 recordsLinked to original sources
PubMed1979

Uncommon neurological presentations of tuberculoma.

The neurological manifestations and autopsy findings of 3 cases of tuberculoma have been described. A cerebello-pontine angle tuberculoma presented with a long history of trigeminal neuralgia. Intramedallary tuberculoma of the spinal cord presented with transverse myelitis, history of one complete remission and a normal myelogram. A tuberculoma of the medulla led to, apart from other features, severe orthostatic hypotension. Tuberculous meningitis, as a terminal process, developed in the first two cases and the third patient died from a vasomotor collapse on suddenly standing up from bed.

Adult↗
PubMed1978

Recent cases of intracranial tuberculomas.

While intracranial tuberculomas have become uncommon in industrial nations, 12 patients with signs and symptoms of an intracranial mass lesion were recently found to have tuberculomas. Clinical findings suggestive of tuberculosis were frequently subtle or absent. Five patients did not have extracranial tuberculosis. Two patients had intracranial tuberculomas that became superinfected with bacteria and appeared initially as pyogenic brain abscesses. Intracranial tuberculomas in this country almost always occur in adults and represent reactivation of dormant infection. Medical therapy alone is indicated as the initial therapy except in the presence of intolerably increased intracranial pressure. A chemotherapeutic regimen is suggested.

Adult↗
PubMed1977

Ultrastructural basis of the vasculopathy in and around brain tuberculomas. Possible significance of altered basement membrane.

The fine structure of small blood vessels in and around ten brain tuberculomas was examined. In the peripheral reactive zone of the tuberculomas, examination of 1-mu-thick survey sections established the chronic inflammatory process and the vasculitis characterized by infiltration of the vasomurium (vessel wall) by large and small mononuclear cells. This reaction was typical of chronic epithelioid cell granuloma. Electron microscopic examination of the reactive zone confirmed the vascular proliferation and vasculitis, the venule being the most frequently involved type of blood vessel. It showed the infiltrating cells to lie amidst osmiophilic, concentrically proliferated basement membrane laminae, which formed the greater part of the thickened vessel wall, generally surrounding the endothelial cells directly, the pericytes having disappeared. This appearance, together with the results of Gomori's reticulin stain on paraffin sections, suggested that the altered basement membrane material was reticulin. The possibility is discussed that the altered basement membrane material could be antigenic and that it might be responsible for perpetuating the necrotic vascular and perivascular reaction in tuberculous meningitis and tuberculomas. The above change in the basement membrane was not encountered in the blood vessels of the surrounding edematous brain. The endothelial cells and tight junctions were relatively well-preserved. Intact arterioles could be recognized even in severely edematous brain tissue. At both sites the fine structure of the blood vessels was typical of that expected in the central nervous system. Fenestrated vessels were not seen. The perivascular astrocytic end-feet were destroyed in the reactive zone and either distended or ruptured in the overtly edematous brain tissue also. In the central caseous part of the tuberculoma, there were few blood vessels, and they were in a state of advanced necrosis, but ghost outlines of proliferated basement membrane could be seen.

Adolescent↗
PubMed1978

Tuberculoma of the liver.

During the period 1973-76 2 patients, neither immigrants, were operated on and found to have tuberculoma of the liver. Both were successfully treated. Tuberculoma of the liver is an uncommon condition and is rarely encountered as a surgical problem. It can, however, present a surgical challenge as it must be distinguished from the more common types of right upper quandrant abdominal lesions such as biliary, gastroduodenal and other hepatic diseases. The occurrence of a tuberculoma of the liver without coexistent tuberculosis elsewhere in the body is extremely rare. Its presence in association with other tuberculous foci, whilst uncommon, has been recorded on a number of occasions.

Aged↗
PubMed1979

Tuberculoma of the central nervous system in Eastern Nigeria.

Although tuberculosis is prevalent in Eastern Nigeria, only 5 cases of tuberculoma of the central nervous system (CNS) were recorded over a 5 year period in a hospital in which about 4000 tuberculosis patients were treated. All the patients were Igbo males. In 4 cases the tuberculoma was supratentorial and in 1 case there was an extradural extraosseous spinal tuberculoma.

Adolescent↗
PubMed1992

Intrasellar tuberculoma.

Intrasellar tuberculoma mimicking a secreting adenoma is a rare occurrence. Although clinical and radiological features were suggestive of pituitary adenoma, histopathological examination following surgery showed a tuberculoma. There were no clinico-radiological features pathognomonic of an intrasellar tuberculoma.

Adult↗
PubMed1976

[Successfully operated case of posterior fossa tuberculoma in childhood (author's transl)].

A case of intracerebellar tuberculoma is described in which a tuberculoma was removed successfully through the administration of antituberculous agents, and a full recovery was obtained. The patient was a 3-year-old boy who had been receiving antituberculous agents for about 4 months because of acute inflammation followed by osteomyelitis of his right big toe, which was suspected to be tuberculous, and because of pulmonary tuberculosis diagnosed in a chest roentgenogram taken about 1 month after osteomyelitis was cured. While his osteomyelitis was being treated, disturbance in his gait, due to progressive spastic paraparesis, was not iced, and thereafter left cerebellar symptoms with impairment of equilibrium appeared additionally. Then, he was reffered to our clinic for further neurosurgical examination, and was admitted on November 1, 1974 after right carotid and vertebral angiography was performed via the right axillar artery, in which findings suggesting left cerebellar tumor and internal hydrocephalus were obtained. After he was admitted to our clinic, a diagnosis of tumor of the left cerebellum and internal hydrocephalus was more precisely confirmed by pneumoventriculography. Suboccipital craniectomy was then carried out and the tumor, weighing 60 gm, was completely removed from the left cerbellar hemisphere. The tumor was confirmed as tuberculoma not only by histological findings but also by the vertification of tuberculous bacilli in it. Though, moderate fever lasted for about 2 weeks postoperatively, no obvious meningitic signs or new neurological deficits were noted. The patient showed marked improvement especially in his gait disturbance, and was discharged ambulatory 40 days after the operation, and has since been asymptomatic except for slight ataxic gait. The antituberculous agents have been continuously administered postoperatively.

Aminosalicylic Acids↗
PubMed1978

Intracranial tuberculomas and the CAT scan.

Tuberculomas of the brain are rare in the United States. Although CAT (computerized axial tomography) scanning cannot distinguish these infections from other intracranial mass lesions, it provides a non-invasive technique with which to follow the course of presumptive lesions during medical therapy, and with which to search for clinically unsuspected infections. The necessity for and timing of surgery can be considered more easily with this technique. Two cases are presented with their CAT scans, including one example of the disappearance of a presumptive tuberculoma, during appropriate medical therapy.

Adult↗
PubMed1977

Spinal extraosseous extradural tuberculoma.

A case of spinal extraosseous, extradural tuberculoma is described. The 42-year-old patient had no other tuberculous lesion detectable elsewhere in his body. Following surgical removal of the tuberculoma the patient achieved complete neurological recovery from a preoperative state of total paralysis in his lower limbs.

Adult↗
PubMed1977

Solitary tuberculoma of the larynx: a case report.

A case of solitary tuberculoma of the larynx in a 56-year-old man from Calabar, Nigeria, is presented. He had upper respiratory tract obstruction severe enough to necessitate a tracheostomy. It is suggested that tuberculoma of the larynx may not be as rare as a review of the currently available medical literature would suggest. More may be discovered if all cases of polypoid masses in the larynx, however innocent they look, are histologically examined.

Humans↗
PubMed1976

Intracranial tuberculomas.

In this paper the clinical findings, operation results and histological diagnosis of eight patients with intracranial tuberculomas are described, which were admitted to the Neurosurgical Clinic of Ankara University, Faculty of Medicine, during the years 1967-1975, among the 1,015 histologically verified intracranial tumours. Our impression by reviewing previous papers on this matter is, that although tuberculomas are not so frequently seen as before, they still count as a certain percentage in Turkey.

Adolescent↗
PubMed1979

[A case of cerebral tuberculoma (author's transl)].

A 27-year-old woman was admitted to other hospital for acute pleuritis in May 1977. She suddenly had a focal epileptic seizure in the face with loss of consciousness on July 10, 1977. The same episodes of seizure occurred on Aug. 8, on Oct. 26, on Nov. 22, 1977. She was admitted to our hospital on Dec. 12, 1977. Neurological examinations showed no abnormality. Chest X-ray film showed bilateral severe thickening of the pleura. Plain skull films showed normal findings. Enhanced CT scanning showed a homogenous irregular contour of high density area surrounded by low density area in the right frontal region. The lateral ventricle was slightly shifted to the left side. 99mTc brain scan also detected a spherical abnormal uptake in this area. Right carotid angiography showed no abnormal vessels and increased vascularities. On Nov. 22, 1977, a craniotomy was made over the right fronto-temporal bone, and a walnut sized tumor in the frontal subcortex was totally removed successfully. Histologically, the tumor was diagnosed as brain tuberculoma. The antituberculous therapy (AB-PC, INAH, Rifampicin), high doses of gammabenin, and steroid were given. About four months later, she was in good health without neurologic deficits and returned to her work. The literature was reviewed, and the value of CT scan and RI scan in the diagnosis of cerebral tuberculoma was emphasized.

Adult↗
PubMed1975

[Differential diagnosis of a round infiltrative tubercular focus and pulmonary tuberculoma].

Clinco-roentgenological findings were studied in 110 patients with ovoid tuberculous infiltrations of the lung, and these were compared with analogous observations of 409 pulmonary tuberculomas. Tuberculous infiltration is frequently of an ovoid shape, its greater diameter being directed along the pulmonary pattern, while a portion of its greater diameter being directed along the pulmonary pattern, while a portion of its contour is distinct and spheroid and directed distally. The reliable criterion of a developed tuberculoma is the symptom of flattening and its distinct peripheral contour, which is not infrequently also flattened.

Diagnosis, Differential↗
PubMed1979

Unusual cerebral tuberculoma.

The unusual occurrence of a cerebral tuberculoma is herewith reported. The first manifestation of the tuberculous infection was an optic perineuritis. Treatment of the "papillitis" with steroids was followed by Jacksonian seizures--the signature of the tuberculoma. Surgical excision has produced a cure.

Adult↗
PubMed1977

[The stratified tuberculoma caused by Mycobacterium kansasii with cavitation (author's transl)].

Report on a 39 years old female textile worker with an acute cavity. M. kansasii was repeatedly isolated by cultivation from the sputum. The patient became negative by treatment with INH, SM, PAS, Ethionamide, but the cavity persisted. Therefore seven months after the onset of the disease the left upper lobe was resected. A colliquative Stratified tuberculoma and some lesions of caseated bronchitis and peribronchitis were found in the neigh bourhood. Clusters and microcolonies of M. kansasii could be observed as well in the wall of the cavity as in the centre of caseated bronchial lesions. The mycobacteria had a characteristic shabe of long segmentated rods. All about the microcolonies situated in the lumina of small bronchi and bronchioli caseated lesions were present, surrounded by specific granular tissue consisting of epithelial cells, some Langhans giant cells, lymphocytes and fibrocytes. The alterations caused by M. kansasii did not differ from those lesions caused by M. tuberculosis (human.) formerly described as stratified tuberculoma and caseated bronchial lesions with mycobacteria centrally located.

Adult↗
PubMed1978

[Isolted spermatic cord tuberculoma (author's transl)].

A case is reported of the postoperative recognition of an isolated tuberculoma of the left pampiniform plexus. This is only the seventh recorded case of an isolated spermatic cord tuberculoma. The findings are interpreted on the basis of the histological report. This case is discussed within the framework of urogenital tuberculosis as an entity according to reports in the literature.

Female↗
PubMed1979

The neuroradiological findings in a case of cerebral tuberculoma.

This paper describes the neuroradioloigical findings in a case of cerebral tuberculoma. Computed tomography demonstrated a mass in contact with the cranial bone with marked contrast enhancement and accompanied by perifocal cerebral edema. External carotid angiography revealed a homogenous stain supplied from the middle meningeal artery. Furthermore, by radioisotope scan it appeared to be a region of increased uptake with a comparatively clear border and was thereby misdiagnosed as meningioma.

Adolescent↗
PubMed1975

Multiple tuberculomas of the brain. Report of a case.

A case of multiple tuberculomas of the brain in a pregnant patient is reported. The symptoms and signs suggested a lesion of the cerebellum which was found to be only congested and oedematous at craniotomy. The correct diagnosis was made at autopsy.

Adult↗