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At least 19 recordsLinked to original sources
PubMed1999

[Modification of drug release with application of pharmaceutical technological methods].

Pharmaceutical technological methods, which enable the development of controlled release, prolonged action solid oral dosage forms, are of great importance. The purpose of our study was to apply these methods and evaluate the prepared samples. The first type of the samples were individually coated separated particles, prepared by mixing with lubricant to built up a lubricant film layer on the surface of the drug crystals. The next group of the samples were separately coated particles--wall material was wax--prepared using the following two technologies: fluidisation atomisation process and hot-melt coating. The third group of the samples was the matrix type, where the core material was mixed into the molten mass of the thermosoftening natural coating material or into some synthetic polymer film material. In some cases several surface active agents were added to the molten mixture to achieve a modification in the drug release process and the examined parameters of the samples. For the comparative evaluation of the prepared dosage forms drug release determination and kinetical analysis of the process were maintainly used. The surface morphology was examined on the base of scanning electronmicroscopic and optical microscopic studies. Among the physical and physico-chemical studies particle size analysis was carried out and dynamic contact angles of the solid samples as well as the surface tension decreasing effect was measured to determine the modifying properties of surface active excipients. To sum up, our results demonstrate that the economical and environmentally acceptable melt coating technology was justified as applicable advantageously in a large number of cases for the development of controlled release devices of highly watersoluble drug, even the medical substance is an organic compound having adjustable thermostability.

Delayed-Action Preparations↗
PubMed1985

Research in the Division of Pharmaceutical Technology.

Within the Center for Bio-Pharmaceutical Sciences the release characteristics of drugs form the major research object of the Division of Pharmaceutical Technology. Transdermal systems are being developed that can supply a drug during several days. Irritation of the skin may be avoided by using hydrogels. To enable long-term transdermal application also the colloidal structure of creams and ointments is investigated. As most drugs are to be taken orally, however, a research project was also started to make cheap and easy to produce controlled release tablets. The results with a microporous polypropylene polymer are promising.

Academies and Institutes↗
PubMed1983

New horizons in pharmaceutical technology.

The benefits they provide have contributed toward making drugs the most commonly used treatment modality. Although drugs account for less than 10 percent of all health care expenditures, their total costs can be substantial when one considers the impact of adverse effects as well as the problems resulting from misprescribing and misuse. The 1980s will see the introduction of a large number and variety of new drugs and new ways of delivering drugs to the body. The goals of these developments include increased effectiveness, decreased seriousness and frequency of adverse effects, and less complicated dosing regimes. This new technology raises questions regarding the optimal prescribing, distribution, financing, and use of these new drugs. It is also important to consider what actions should be taken to assure that continued growth in drug technology will occur and that this growth be directed toward the development of drugs that offer significant advantages over existing therapies. Rational policy must consider not only the costs of drugs themselves but also the potential for drugs to reduce the overall cost of health care.

Cost-Benefit Analysis↗
PubMed1992

[Relationships between manufacturing parameters and pharmaceutical-technological requirements of biodegradable microparticles. 2. Preparation of injectable microparticles in biodegradable polyester].

Local anesthetics containing biodegradable polyester microparticles are prepared using a modified solvent-evaporation process and a spray drying technique. The preparation methods are compared critically. The modified solvent-evaporation process is preferred for the preparation of microparticles. Yields of 90% and microparticle size distributions can be influenced in a reproducible manner. Using the spray drying technique yields are only 60%. The product is characterized by a high portion of microparticles under 10 microns, which are responsible for the rapid release of cinchocain in 168 h as well.

Anesthetics, Local↗