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[Contribution of spiral CT scan and MRI in spinal tuberculosis].

Spinal tuberculosis is the most frequent skeletal involvement in tuberculosis. The purpose of this study was to demonstrate the importance of the MRI and the helicoidal CT scan in the diagnosis of spinal tuberculosis. A retrospective study was conducted in 23 patients with spinal tuberculosis. The methods of investigation were helicoidal CT scan in 15 patients and MRI in the other eight patients. In the all cases with helicoidal CT scan, the features of the spinal tuberculosis were seen as an anterior vertebral body destruction with a paraspinal or epidural extension in 12 cases and a sequestrum formation in 5 cases. The analysis with helicoidal CT scan showed a gibbous deformity in 5 cases, a disk space narrowing in 14 cases and evaluated the extension very well. The MR imaging features showed one case in an early stage without features on the plain radiographs, and detected 3 cases of intramedullary lesions. A disruption of the longitudinal posterior vertebral ligament was found in one case and skip lesions at the granulomatous stage in 2 cases. MRI is superior to CT scan even helicoidal CT at the early lesion stage, skip lesions and the ligamentous or medullary lesions. For other lesions (bone, disk, extension), the MRI and CT scan are the same with an advantage for CT scan in osseous lesions.

Adult↗

The outcome of allografts and anterior instrumentation in spinal tuberculosis.

Spinal tuberculosis is the most common form of osteoarticular tuberculosis. Fractures, slippage, and increasing deformity have been reported with the use of autologous rib grafts after anterior spinal decompression. Forty-one patients with neurologic deficits caused by spinal tuberculosis had radical anterior decompression, and the anterior column was reconstructed with fresh-frozen femoral allografts and stabilized with a single-rod screw construct. Antituberculous therapy was administered for 12 months and complete neurologic recovery occurred in 32 patients. The incorporation of allografts commenced between 12 and 18 months. Fusion and remodeling was observed in 33 patients and partial remodeling with fusion was observed in eight patients at a mean followup of 6.4 years. Forty-two percent correction of the kyphosis was achieved and there were no cases of fracture or late sepsis. Fresh-frozen allografts and anterior instrumentation are superior to rib grafts in supporting the anterior spinal column, and although fusion occurred late, the grafts remained stable.

Adolescent↗

The problem of deformity in spinal tuberculosis.

Spinal tuberculosis is the most common cause for a kyphotic deformity in patients in many parts of the world. There is an average increase of 15 degrees deformity in all patients who are treated conservatively and 3% to 5% of patients may end up with a deformity that is greater than 60 degrees. The progress of deformity occurs in two distinct phases: Phase I, which includes the changes in the active phase, and Phase II, which includes changes after the disease is cured. The progress of deformity is influenced by the severity of the angle before treatment, the level of the lesion, and age of the patient. Adults have an increase less than 30 degrees during the active phase with no additional change. Children, in contrast, have significant changes even in the healed phase of the disease. During the growth spurt, there is worsening of the deformity in 39% (Type I progression), an improvement in 44% (Type II), and no change in 17% (Type III). Children at risk of late progressive deformity can be identified early by the presence of spine-at-risk radiologic signs. Surgery for preventing deformity must be done earlier rather than later and in patients with severe disease, stabilization by the use of posterior and anterior instrumentation is necessary to obtain a good outcome.

Adult↗

Spinal cord compression of dual etiology, multiple myeloma and spinal tuberculosis.

Spinal cord compression as an initial manifestation of multiple myeloma is a well-known phenomenon. We report for the first time a patient with spinal cord compression of dual etiology, multiple myeloma and spinal tuberculosis, treated successfully by local radiotherapy, chemotherapy and an antituberculous regimen.

Combined Modality Therapy↗

Spinal tuberculosis.

Spinal tuberculosis is an important and potentially crippling disease, but if recognized early and treated energetically it can be brought under control, often with very gratifying results. Knowledge of the exact bacteriology and sensitivity pattern of the organisms involved can be very helpful indeed, and should be sought where possible.

Humans↗

Atypical spinal tuberculosis.

Typical spinal tuberculosis is readily diagnosed and treated. Certain atypical clinical and radiologic presentations of spinal tuberculosis are described. Failure to recognize these presentations may lead to delay in diagnosis and initiation of treatment. In some atypical forms of the disease, this may have disastrous consequences. The current authors present a new classification for atypical spinal tuberculosis and describe the various presentations. The role of advanced imaging studies such as computed tomography scanning and magnetic resonance imaging and imaging-guided aspiration cytology is discussed.

Diagnosis, Differential↗

Vertebral arch or posterior spinal tuberculosis.

Posterior spinal tuberculosis or arch tuberculosis is a form of skeletal tuberculosis that selectively involves the vertebral arch. It may mimic skeletal neoplasm clinically and radiographically. Although posterior spinal tuberculosis has been reported in developing countries it has rarely been found in the United States. As a result, there is limited information about this entity in the US literature. We are presenting our experience in a patient born in the United States.

Antitubercular Agents↗

Atypical spinal tuberculosis in children.

Spinal tuberculosis characteristically involves two contiguous vertebral bodies with narrowing of the disk space. We report on 11 children with atypical spinal tuberculosis. Three had disease confined to a single body, four had extradural extraosseous involvement presenting as an abscess, and isolated infection of the neural arch was seen in four children. Seven children had neurological involvement. Treatment included posterior decompression for the extradural extraosseous involvement, biopsy and drainage for the neural arch infection, and anterior decompression and fusion for the single-body disease. The patients had antituberculosis treatment for 18 months, and all seven children with neurological involvement recovered.

Abscess↗

[A case of miliary tuberculosis with multiple cerebral tuberculoma and spinal tuberculosis owing to total delay].

We reported a case of miliary tuberculosis with multiple cerebral tuberculoma and spinal tuberculosis. The case was a 37 year old man. In the last sixteen months to the first visit to a hospital, he has been suffering from low grade fever, cough, and back pain, but he bared his symptoms without any therapy. At a hospital he first visited, he was told that he might have a malignant disease, which prevented him to visit the hospital because of a fear for his disease. Six months later, he was admitted to other hospital because of severe back pain. At last, he was diagnosed as tuberculosis and referred to our hospital. By the examinations on admission he was diagnosed as multiple cerebral tuberculoma and spinal tuberculosis, and anti-tuberculous therapy was started. It is thought that his severe disease status on admission is caused by the total delay, namely the delay in visiting a doctor and the doctor's delay in making diagnosis.

Adult↗

Some problems in diagnosis and management of spinal tuberculosis.

In Victoria spinal tuberculosis is now rare in childhood. Some features of the disease in adults are described. A paravertebral abscess, although a late feature of the disease, is commonly present before a diagnosis is made. Antituberculosis drug therapy has greatly altered the pattern of healing of both the bone lesion and, in contrast to the era before chemotherapy, the healing of the abscess is no longer the dominant factor in the healing of the bone lesion. The controversy about radical surgery is discussed.

Abscess↗

Spinal tuberculosis revisited.

Although the incidence of tuberculosis is decreasing, spinal tuberculosis is still an important disease. Delay in diagnosis and treatment results in long-term disability. We reviewed our cases of spinal tuberculosis diagnosed between 1975 and 1982, with special reference to those features that permit early diagnosis. Among the nine cases diagnosed, roentgenographic evidence of pulmonary tuberculosis (7/9) and positive PPD test (8/8) were found to be highly suggestive diagnostic clues. Computerized tomography (CT) of the spine was a useful way of determining the extent of the disease and following response to therapy. Various modes of therapy were used, and the outcome was related to the extent of the disease and duration of symptoms before initiation of therapy. In early stages, medical therapy alone is adequate; surgical intervention is necessary in cases with neurologic features.

Adult↗