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Results for “TESTICULAR NEOPLASMS”

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At least 19 recordsLinked to original sources
PubMed1982

Sonographic detection of occult testicular neoplasms.

Testicular sonograms were performed in four patients with pathologically proven metastatic neoplasms but a normal physical examination of the scrotum. An abnormal echo texture was seen in all cases: focal hypoechoic nodule (about 1 cm) in two, diffusely hypoechoic in one, and mixed diffuse/focal abnormality in one. Correct sonographic identification of the abnormal testis facilitates surgical removal and precludes unnecessary excision of the contralateral normal testes. The authors recommended testicular sonography to be used as a routine procedure in all patients with such a clinical presentation.

Adenocarcinoma↗
PubMed1980

Spontaneous testicular neoplasm in mice with testicular feminization.

Testicular neoplasms occur spontaneously in androgen insensitive mice with testicular feminization (tfm/y); they are composed of Leydig cells, lipid-laden cells, fibroblastlike cells, and macrophages. The small Leydig cells in the periphery of the tumor are structurally similar to nontumorous tfm/y Leydig cells, whereas centrally located large Leydig cells contain numerous lipid droplets, mitochondria with tubular cristae, and abundant smooth endoplasmic reticulum. The lipid-laden cells exhibit a crescentic nucleus which is displaced toward the periphery of the cytoplasm by a large lipid vacuole. The fibroblastlike cells have a large amount of rough endoplasmic reticulum, lysosomes, free ribosomes, and lipid vacuoles. Macrophages are characterized by numerous layered and dense osmiophilic structures closely associated with crystalshaped bodies. An in vitro study shows that, in comparison with the normal testes, the tfm/y tumors produce significantly less testosterone but a larger quantity of androstenedione. Also, the tumors are capable of converting progesterone to estrone and estradiol-17 beta. The plasma level of testosterone is significantly lower in tumor-bearing animals than in normal littermates, but slightly higher than in the nontumorous tfm/y animals. Since the abnormal steroid enzyme activity is found in both tumor-bearing and nontumorous tfm/y mice, the basic cause of aberrations in sex steroid production appears to be genetic rather than the direct result of alterations in their Leydig cells.

Androgen-Insensitivity Syndrome↗
PubMed1987

Expression of growth regulatory genes in primary human testicular neoplasms.

Seven testicular tumours of different histological type--two seminomas, two teratomas/teratocarcinomas/embryonal carcinomas, one mixed seminoma/teratoma, one Leydig cell tumour and one testicular lymphoma--were examined for the expression of four potentially growth regulatory genes by Northern blotting. Seven out of seven testicular tumours contained transcripts that hybridized with a human insulin cDNA-probe whereas only four out of seven tumours contained IGF II transcripts. One tumour contained high levels of LDL-receptor transcript whereas all seven tumours contained significant quantities of HMG-CoA-reductase mRNA.

DNA↗
PubMed1980

[Familial occurrence of testicular neoplasms (author's transl)].

Testicular malignancies in closely related family members are rare, 22 cases have been published before. Our report describes the eleventh case of testicular tumors in non-twin-brothers and the first case with histologically verified bilateral tumor in one brother. We also report about another case of testicular neoplasms in identical twin brothers.

Adult↗
PubMed1982

[Cytodiagnosis of prostatic and testicular neoplasms].

Struck by delays in the diagnosis of carcinomas of the prostate and testis, the authors have developed a method for cytological study by puncture of those organs. During a 7 year period, they saw 100 carcinomas of the prostate, 94% of which had already spread beyond the prostate with bone metastases in 48%. During the same period, 18 carcinomas of the testis were seen, with several erroneous differential diagnoses which led to a delay in diagnosis (mean: 12 weeks). The authors use a Franzen-type aspiration needle which makes possible puncture and aspiration of the tumour zone without hospitalisation of the patient. Cytological diagnosis implies the need for considerable experience, bearing in mind that in particular certain excessively deep punctures of the prostate may yield cells from the seminal vesicles which lead to an incorrect diagnosis of carcinoma of the prostate. Such aspiration cytology may be used to differentiate between benign and malignant tumours, as well as providing a more accurate diagnosis in terms of the type of tumour and the degree of differentiation.

Biopsy, Needle↗
PubMed1989

[Bilateral testicular neoplasms].

Three cases of bilateral testicular neoplasms were found in 112 patients treated in the last 7 years. In two patients bilateral seminoma developed at various time periods. In one case seminoma coexisted with germinal carcinoma.

Adult↗