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Results for “Syphilis, Latent”

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At least 19 recordsLinked to original sources
PubMed1993

Comparison of early and late latent syphilis--Colorado, 1991.

Latent syphilis (i.e., the presence of serological evidence for syphilis without clinical manifestations) is divided into early latent ([EL] less than 1-year's duration) and late latent ([LL] more than 1-year's duration) stages (1). LL syphilis, which is often associated with low nontreponemal test (e.g., rapid plasma reagin [RPR]) titers and is presumed to have been acquired in the distant past, is not routinely included in syphilis surveillance reports and analyses. Although a separate classification of "unknown latent syphilis" has been proposed (1), in practice, duration is unknown for nearly all syphilis cases that are classified as LL. This report compares EL and LL syphilis cases in Colorado during 1991 and demonstrates substantial overlap in their characteristics.

Adolescent↗
PubMed1981

Penetration of penicillin into the cerebrospinal fluid of patients with latent syphilis.

Eighteen patients with latent syphilis were treated with 360 mg, 720 mg, 1080 mg or 1440 mg intramuscular procaine penicillin daily for 14 days. Penicillin was assayed in serum and cerebrospinal fluid collected 3 hours after the second injection in each patient. Penicillin was present in all sera in concentrations greater than the generally accepted fully treponemacidal level, but none was detected in cerebrospinal fluid from 11 patients. The significance of these results is discussed, particularly with a view to changes in standard treatment regimens for latent syphilis.

Adolescent↗
PubMed1983

[Circulating immune complexes in treated latent syphilis].

22 patients with treated latent syphilis were studied by the method of anticomplementary activity. The patients did not have any antecedent of primary or secondary muco-cutaneous lesion or any other clinical or humoral manifestation of other diseases. The presence of circulating immune complexes with statistical significance were shown in 14 cases. Syphilis in this period is considered as an immuno reactive disease, obliging to periodic clinical and specialized laboratory controls.

Adult↗
PubMed1992

Response of latent syphilis or neurosyphilis to ceftriaxone therapy in persons infected with human immunodeficiency virus.

OBJECTIVE: To evaluate the effect of ceftriaxone in treating latent syphilis or asymptomatic neurosyphilis in patients infected with the human immunodeficiency virus (HIV). DESIGN: Follow-up study of patients treated at two HIV-based clinics during 16 months from 1989 to 1991. PATIENTS: Patients were those in whom a clinical diagnosis of latent syphilis or asymptomatic neurosyphilis was made, who received all recommended doses of antimicrobial therapy, and who returned for follow-up visits for 6 or more months. RESULTS: Forty-three patients were treated with ceftriaxone, 1 to 2 g daily for 10 to 14 days. Thirteen underwent lumbar puncture before treatment; 7 (58%) had documented neurosyphilis (pleocytosis in 5, elevated protein levels in 6, VDRL reactive in cerebrospinal fluid [CSF] in 7), and 6 had documented latent syphilis (entirely normal CSF). The remaining 30 were said to have presumed latent syphilis. There was no relation between the diagnosis and the selected dosage of ceftriaxone. Response rates were similar in those who had documented neurosyphilis and documented or presumed latent syphilis. Overall, 28 patients (65%) responded to therapy, 5 (12%) were serofast, 9 (21%) had a serologic relapse, and 1 (2%) who experienced progression to symptomatic neurosyphilis was a therapeutic failure. Thirteen patients received benzathine penicillin for presumed latent syphilis; results were similar to those observed after ceftriaxone therapy, with 8 (62%) responders, 1 (8%) serofast, 2 (15%) relapses, and 2 (15%) failures. CD4 cell counts in responders were not different from those who failed to respond. CONCLUSIONS: Even in the absence of neurologic symptoms, half of the HIV-infected persons who have serologic evidence of syphilis may have neurosyphilis. Although ceftriaxone achieves high serum and CSF levels, 10 to 14 days of treatment with this drug were associated with a 23% failure rate in HIV-infected patients who had latent syphilis or asymptomatic neurosyphilis. Three doses of benzathine penicillin did not have a significantly higher relapse rate and may provide appropriate therapy, at least for documented latent syphilis in persons co-infected with HIV. Studies comparing ceftriaxone with 10 to 14 doses of procaine penicillin are needed to determine the most cost-effective treatment for asymptomatic neurosyphilis or presumed latent syphilis in this group of patients.

Adult↗