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Neonatal narcotic abstinence: Effects of pharmacotherapeutic agents and maternal drug usage on nutritive sucking behavior.

An uncoordinated and ineffectual sucking reflex is a major manifestation of neonatal narcotic abstinence and may have important consequences for the infant's subsequent well being. Measures of nutritive sucking were used to monitor the severity of neonatal narcotic abstinence in a series of infants born to narcotic-dependent mothers who were either attending the methadone clinic or else were "street addicts." In all these infants, sucking measures were significantly reduced relative to normal control subjects. Furthermore, the sucking behavior of infants born to mothers attending the methadone clinic was significantly more depressed than that of infants born to street addicts. In regard to the salutary effects of pharmacotherapy for neonatal narcotic abstinence, infants treated with paregoric approached normal control levels and showed significantly better sucking than those treated with phenobarbital or diazepam. The latter drug practically eliminated all spontaneous nutritive sucking behavior.

Diazepam

Pattern of sucking in the infant rat during spontaneous milk ejection.

Two methods are described for measuring the sucking of rat pups on the nipples of the mother. The first uses pressure recording of the cannulated teatduct; the second uses direct observation of sucking behavior. Using these methods, the sucking behavior of the pups during sequences of milk ejections was investigated. Pressure recordings of the sucking of individual pups on the nipple showed that between milk ejections the pups sucked intermittently in bursts. During milk ejection itself there was a longer period of vigorous and continuous sucking. Behavioral observations on the level of sucking in whole litters of pups showed that the background bursts of sucking from the litter as a whole were randomly distributed in relation to the inferred time of oxytocin release. These results indicate that once the pups are sucking on the nipples, variations in the sucking behavior of the litter have no role in the timing of milk ejections in the mother.

Animals

Effects of auditory stimulation upon non-nutritive sucking by premature infants.

Changes in non-nutritive sucking contingent upon presentation of an auditory stimulus previously found capable of eliciting heart-rate acceleration was investigated in a sample of 24 premature infants. Across 30 10-sec. presentations of the stimulus, only transient changes in sucking rate during the first 6 trials were observed, and these effects obtained primarily for those infants showing few abnormalities in their non-nutritive sucking behavior. These results were discussed as reflecting possible differences in infants' attention associated with sucking pathology and the dependence of psychological assessment upon the specific response index used.

Attention

Neonatal nutritive sucking: effects of taste stimulation upon sucking rhythm and heart rate.

The sucking behavior and heart rate of 22 full-term newborns were recorded. Half of the infants sucked for 9 minutes in 3 blocks of 3 minutes, first receiving a 0.02-ml drop of 5% sucrose for each criterion suck, then no fluid contingent upon such sucks, and finally a 0.02-ml drop of 15% sucrose for each suck. The other half received these conditions in reverse order. Regardless of the order in which the 2 nutrient conditions were administered, intersuck intervals were longer under the sweeter condition, but heart rate was also higher. Possible interpretations include a hedonic explanation suggesting that sucking rate is modulated to facilitate savoring of the sweeter fluid.

Heart Rate

The stability and interrelationships of newborn sucking and heart rate.

The sucking behavior of 44 newborns was recorded along with heart rate (HR) and respiration. These 3 systems showed stability over a 24-hr period. Sucking parameters varied markedly depending upon whether the infant was sucking for sucrose or under a no-fluid condition. Moreover, HR was strikingly affected by sweetness. The direction of HR change was toward increasing rates when sucking for sweet, even though sucking for sweet substances occurs more slowly than for no fluid.

Female

A study on the ecological habit of Armigeres subalbatus in Dawa area of the Mengshan Mountain in Shandong Province.

Armigeres subalbatus (A.s.) was reported in Shandong Province for the first time in 1965 and found in five counties of south Shandong including Pingyi, Linyi etc. in 1986. In Dawa area of the Mengshan mountain A.s. alults could be found in the first ten days of May, which increased in number in July, and become the dominant species in mosquito colonies in Aug. and Sept., then decreased gradually in number in Oct. and disappeared in Nov. There were two peaks of activity and blood-sucking behavior during the 24 hours of a day, one at dusk and the other at dawn. When the temperature dropped to 16 degrees C and below in the last ten days of Oct., the wigglers began their diapause period. The survival ratio reached 90.5% after 12 h freezing at -5 degrees C and none survived after 60 hours freezing. When the temperature rose to 17 degrees C and above the over-winterting larvae developed into adults, which could suck blood only at the temperature above 17.5 degrees C.

Animals

Olfactory bulbectomy and nursing behavior in rat pups (Wistar DAB).

To determine whether bilateral olfactory bulbectomy led to a change in nursing behavior, and thus death, we bilaterally bulbectomized (BX) pups from 14 litters at 2, 7, and 11 days of age. Litters treated on Days 2 and 7 consisted of 3 BX pups, 2 surgical control (SC) pups, and 2 handling control (HC) pups. Litters treated on Day 11 consisted of 1 or 2 BX, 1 or 2 incompletely bulbectomized pups (IBX), 2 SC pups, and 2 HC pups. These litters and 3 additional nontreated litters were observed on Days 4,7,10,13, and 16. A smaller number of BX pups survived through Day 10 than SC, HC, IBX, and nontreated pups. Differential treatment of the BX pups by females or littermates was not found. The females' mammary glands were functional but the BX pup stomachs had little or no milk. The BX pups spent less time nursing and more time away from the female and their littermates than did the other pups.

Animals

Effects of ethyl alcohol on behaviour in nursing female mice.

Effects of administering 10% ethyl alcohol as drinking fluid to mice during pregnancy and lactation have been examined by ethological analysis of behaviour of nursing females in their home cages at 1 day, 5--7 days, and 12--14 days postpartum. The treatment with alcohol did not affect gestation period or litter size, and fluid intake of treated mice remained similar to that of controls, the average intake of alcohol amounting to 29 mg/g body weight during lactation. Increase in frequency of exploration at 1 day postpartum was the only significant behavioural effect of alcohol on the nursing female mice. Duration of Non-Social Behaviour was unaltered, and no effects of the treatment on Maternal Behaviour or on Social and Sexual Investigation of male partners could be demonstrated. Behaviour of nursing females changed with increase in age of their pups. This occurred to a similar extent in treated and control animals. Maternal and Non-Social Behaviours declined in frequency as the pups became older although the time spent in these behaviours remained fairly constant. Social Investigation of the male partner declined both in frequency and duration while females were nursing their pups.

Animals

Social and reproductive behaviors in surrogate-reared squirrel monkeys (Saimiri sciureus).

A colony of 16 surrogate-reared squirrel monkeys was observed for the adequacy of social and reproductive behaviors at maturity. Aside from some self-directed abnormalities centering around nonnutritive orality, this group was behaviorally normal in spite of having no contacts with mother-reared, older conspecifics. Half (N=5) of the females gave birth, with four infants viable. One infant has remained with the colony and is thriving. The other three remained with the group for as long as 42 days before death or removal. Maternal care appeared adequate. Mean estimated conception age for females was 35 months, and the mean impregnation age for males was estimated to be 42 months.

Animals

Effects of nonnutritive sucking upon the behavioral arousal of the newborn.

The sample consisted of 20 typical Caucasian infants, 10 males and 10 females, equally distributed between the experimental and control groups. Experimental infants were offered a nonnutritive nipple and permitted to suck to satiety at 1, 4, and 8 hours of age. All infants were offered their first feeding at 12 hours of age. Behavioral arousal of all infants, assessed in accord with the Behavioral Inventory for Assessing States (BIAS), was recorded during comparable time periods at 1, 4, 8, and 12 hours of age. Duration of nutritive sucking, quantity of nutriment consumed, frequency of bubbling, and time required to bubble the infant were monitored during the first feeding. The experimental group engaged in behavioral states characterized by sleep or irritability less frequently and in states characterized by alert wakefulness more frequently than the control group. Feeding exerted no effect upon the behavioral arousal of either group. The experimental group required less time to bubble during feeding than the control group. Results are related to early infant stimulation and to the infant as stimulus in infant-caretaker interaction.

Arousal

The milk ejection of the rat, as a stimulus and a response to the litter.

A finding that the milk ejection of the rat is stimulated effectively only if at least half the pups are suckled is confirmed. This relationship, however, is found if the mother is anaesthetized but not if the mother is conscious. If the mother is conscious, the milk obtained by individual hungry pups is unaffected by the number of other hungry pups suckled. This is true whether the other pups of the litter are removed, or whether they are present but satiated. After the milk ejection, pups tend to leave the mother's nipple. Milk yield decreases with each milk ejection of a series, but getting less milk does not make the pups more likely to leave the nipple in search of another.

Animal Population Groups

Maternal influences on ontogeny of suckling and feeding rhythms in the rat.

To assess the effects of both maternal and endogenous factors on the ontogeny of nocturnal feeding in the rat, day and night weight gain was determined in the sighted or blind litters of sighted or blind litters of sighted or blind dams and in young weaned at 15 days of age. Sighted dams impose a diurnal milk-intake pattern on their young. The nocturnal pattern of solid-food intake begins at 19 days of age. Blind litters also display nocturnal feeding when kept with sighted dams, but only until 35 days of age.

Age Factors

Compensatory responses of goat mothers to their impaired young.

The behaviour of a mother goat towards her young normally compensates for differences between them in their vigour at birth. Weakening the first-born with drugs still does not prevent its getting equal access to the udder, though weakening the second-born may render it so much less vigorous that maternal compensation does fail. When the mother is unable to distinguish her kids by sight or smell, she is unable to modulate her responses to the kids and then the more vigorous kid always establishes priority of access to the bladder. We conjecture that this is what normally occurs under harsh environmental conditions where the mother's milk supply is occasionally inadequate for two kids.

Anesthesia

Common sexual problems of children and adolescents.

The pediatrician is often expected by families to deal with sexual problems of children and adolescents. The physician should be able to identify problems and to guide parents in more meaningful communication and education of their children. Hopefully, he will be able to identify family conflicts and make the appropriate intervention or referral. He should be aware of his own sexual attitudes so as to avoid having his bias interfere with treatment. The childs behavior should not be isolated, but considered in the context of his family, his peers, and his own growth and development. Often, it is more useful to advise the family than to work with a young child. Adolescents present particular problems because of their conflicts over sexual identity, their reluctance to admit to problems, and frequently a mistrust of adults. They often feel a need for a trusting relationship with an adult, however, and are able to relate to a sensitive, non-judgmental professional.

Adolescent

Weaning and growth of artificially reared rats.

The importance of suckling experience for later feeding in the rat was tested by means of an isolate rearing technique that eliminated oral feeding. Pups reared in the nearly complete absence of suckling and feeding ate and drank at weaning and then grew normally. Furthermore, the characteristics of apparently normal ingestion and growth make the artificially reared rat a useful preparation for other developmental investigations.

Animals