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At least 19 recordsLinked to original sources
PubMed1986

Involvement of the midbrain reticular formation in self-injurious behavior, stereotyped behavior, and analgesia induced by intranigral microinjection of muscimol.

Bilateral microinjection of muscimol (60 ng), a gamma-aminobutyric acid (GABA) agonist, into the central region of the substantia nigra (pars reticulata) produced self-injurious behavior (SIB), stereotyped behavior and analgesic-like effects in rats. Bilateral electrolytic lesions of the midbrain reticular formation ventrolateral to the periaqueductal gray matter completely blocked the SIB but had little effect on stereotyped behavior produced by intranigral muscimol. Lesions of the midbrain reticular formation reduced the antinociceptive effect of intranigral muscimol on the tail-flick but not on the hot-plate test. Bilateral microinjection of muscimol (10-100 ng) into the midbrain reticular formation produced intense stereotyped behavior and had an analgesic-like effect on the hot-plate test but not on the tail-flick test. Stereotyped behavior appeared to interfere with the paw-lick response on the hot-plate test. These data suggest that the antinociceptive effect of intranigral muscimol on the tail-flick test is mediated by fibers that project to or pass through the midbrain reticular formation and that analgesia may play an important role in muscimol-induced SIB. The midbrain reticular formation does not appear to be involved in the stereotyped behavior produced by intranigral muscimol.

Animals↗
PubMed2005

Striatal opioid peptide content in an animal model of spontaneous stereotypic behavior.

Stereotypic behaviors are associated with a broad spectrum of developmental, psychiatric, and genetic disorders. Several lines of evidence indicate that these abnormal repetitive behaviors may be expressed as a consequence of imbalanced activity along the direct and indirect processing pathways of the basal ganglia. Because the activity of these two pathways is modulated, in part, by the neuropeptides dynorphin and enkephalin, we sought to determine whether spontaneous and persistent stereotypy is associated with alterations in striatal neuropeptide content. Specifically, the present study employed radioimmunoassay to measure dynorphin-A and leu-enkephalin content in the dorsolateral striatum of deer mice exhibiting different levels of spontaneous stereotypic jumping. The results indicate significantly decreased leu-enkephalin content and significantly increased dynorphin/enkephalin content ratios in high-stereotypy mice relative to low-stereotypy mice. Moreover, analyses revealed a significant negative correlation between striatal enkephalin content and frequency of stereotypy as well as a significant positive correlation between the dynorphin/enkephalin content ratio and frequency of stereotypy in these mice. These data are consistent with the hypothesis that spontaneous stereotypic behavior is expressed as a consequence of relative hyperactivity along cortico-basal ganglia-cortical feedback circuits involving the direct (facilitative) pathway, but suggest that primary perturbations to the indirect (inhibitory) pathway give rise to such imbalanced activity.

Animals↗
PubMed1998

Subtyping stereotypic behavior in children: the association between stereotypic behavior, mood, and heart rate.

The stereotypic behavior of children (N = 26) while in a playroom session with their parent was studied. The sample included children with a pervasive developmental disorder, an attention-deficit/hyperactivity disorder, a developmental expressive language disorder, or a developmental receptive language disorder and normally developing children. Stereotypic behaviors associated with distress, elation, and composure were compared on mean duration and form of the stereotypies and heart rate changes around the onset of the stereotypies. Results showed that stereotypies associated with different moods differed in all variables studied. Results confirm that a valid classification scheme for stereotypic behaviors is needed as they indicate different functions of individual stereotypies.

Affect↗
PubMedDate not supplied

[Interaction of stereotypic behavior in mice and effects of activation of presynaptic dopaminergic receptors in extinction and amnesia].

Using the methods of agonistic confrontations of C57BL/6J mice for formation of aggressive and submissive types of behavior and passive avoidance training we investigated the influence of activation of dopamine presynaptic receptors on retention of a memory trace during extinction and amnesia. Autoreceptor agonist (+)3PPP (2 mg/kg, intraperitoneal injection) impaired learning and retention of a memory trace during extinction and strengthened the amnestic influence of animal detention in a dangerous compartment on the training day only in aggressive mice. In submissive mice, (+) 3PPP improved the retrieval of passive avoidance during extinction but did not change the development of amnesia. This work was the first to demonstrate that the effects of dopamine autoreceptor activation on the passive avoidance retrieval depend on behavioral stereotype (aggressive or submissive). It is suggested that different basic states of the dopaminergic system in aggressive and submissive mice are responsible for different (+) 3PPP effects.

Aggression↗
PubMed1986

Behavioral, physiological and functional aspects of stereotyped behavior: a review and a re-interpretation.

Stereotypies are repetitive actions that are fixed in form and orientation and serve no obvious purpose. Their occurrence in farm animals submitted to intensive husbandry has been interpreted to indicate inadequate environmental design or welfare. Over recent years, detailed descriptive studies have led to a better understanding of the organization and development of stereotypies, particularly in pregnant sows housed in tether stalls. Stereotyped behaviors appear to emerge from elements of initial defensive reactions of animals to their environment. They develop via a progressive narrowing of the behavioral repertoire, until only self-directed behaviors are displayed. Pharmacological studies suggest that performance of stereotyped behavior depends on the brain dopamine systems that are involved in selection and initiation of motor movements. However, generalization of these data to natural stereotypies is doubtful. Recent evidence favors an involvement of brain opioid peptides in stereotyped behavior of sows, although the exact mechanisms remain unknown. Stereotypies are typically observed in situations of conflict or frustration. They have been claimed to have an adaptive function, either by providing self-generated sensory stimulation to compensate for the lack of environmental stimulation, or by allowing animals to discharge their tension or anxiety. However, there is little evidence in favor of either interpretation. On the basis of present knowledge, it is proposed that stereotyped activities gain strength because of the positive feedback effect of sensory stimulation on their underlying control systems, which leads to a progressive sensitization of these neural systems. Stereotypies would then be simply the outward expression of an activation of lower brain structures controlling motor behavior which occurs in the absence of normal inhibitory control by higher nervous functions.

Animals↗
PubMed1986

Use of differential reinforcement of other behavior during dyadic instruction to reduce stereotyped behavior of autistic students.

Effects of a differential reinforcement of other behavior procedure (DRO) on the stereotypic responses and task performance of 3 autistic students during dyadic instruction were examined. The procedures effectively reduced the stereotypic behavior of 2 children and substantially increased the task performance of the 2 lowest performing students. The procedure was unique because the time interval employed between potential opportunities for reinforcement for the absence of stereotypy was the natural length of one instructional trial delivered to a peer. Results were discussed in terms of models for intervention within task context and the usefulness of the procedure under natural teaching conditions.

Adolescent↗
PubMed1978

Ouabain induced stereotyped behavior in rats.

Stereotyped behavior was induced in rats with ouabain administered intraventricularly in doses of 2, 3 and 4 microgram in 50 microliter saline. Haloperiodol reduced the stereotyped behaviour. Monoamine turnover studies showed a reduction in concentration of norepinephrine in hippocampus and midbrain, an increase in norepinephrine turnover in the medulla oblongata and a reduction in dopamine turnover in the striatum. The interpretation of these finds is discussed. It is suggested that this model could be significant clinically as it demonstrates that impairment of Na+-K+-ATP'ase may result in behavioral abnormalities characterised by stereotypy.

Animals↗
PubMed1996

Locomotive stereotyped behavior in cynomolgus macaques, Macaca fascicularis.

Primate infants separated from their mothers and kept alone for a long period may exhibit behavioral disorders and develop stereotyped behavior according to genetic predispositions of the infants and environmental factors such as characteristics of the cage. However, it is not clear whether the locomotive and repetitive stereotyped behaviors are related to maternal separation or isolation rearing early in life. The locomotive and repetitive stereotyped behaviors and their relationship were examined with 65 juveniles of cynomolgus macaques kept under artificial conditions. All infants were separated from their mothers and kept with peers. Observations were conducted when they were about three to five years old. The monkeys exhibited locomotive and repetitive stereotyped behavior such as turning, backward somersaulting, and bouncing. Most showed both turning and backward somersaulting. Observations indicated that social interactions with peers following maternal separation at the age of 3 to 5 mo. produce the locomotive and repetitive stereotyped behavior and that turning may change to backward somersaulting for older infants. Further work with controls for several factors is needed.

Age Factors↗
PubMed2005

Survey of stereotypic behavior in prosimians.

Captive animals have been observed to perform a variety of stereotypic behaviors. However, little is known about stereotypic behavior in prosimians. We sent surveys to 96 AZA-accredited institutions to examine stereotypic behavior in these primates. Forty-eight surveys were returned, providing information on 440 individuals of 10 genera. According to the responses, 13.2% of the prosimians surveyed exhibited some form of stereotypic behavior. Pacing was the most common behavior. A logistic regression was used to examine intrinsic characteristics that might influence the performance of stereotypic behavior. The genus of the prosimian was a significant predictor of stereotypic behavior. Individuals of the genus Varecia and Microcebuswere more likely to engage in stereotypic behavior than members of the other genera. Rearing history, age, and sex were not significant predictors of stereotypic behavior. To examine the influence of extrinsic variables on stereotypic behavior, we transformed the data into the percentage of individuals within the enclosure that were reported to exhibit stereotypic behavior, and analyzed them at the enclosure level using a general linear model (GLM) analysis of variance (ANOVA). The only environmental variable that significantly predicted stereotypic behavior was the frequency with which enrichment was provided. Frequent enrichment was provided to those exhibits with a higher percentage of prosimians that engaged in stereotypic behavior. The results of this survey suggest that stereotypic behavior in prosimians may be associated with intrinsic factors (i.e., individual or genus differences) in addition to extrinsic factors related to housing. This knowledge may be helpful in identifying the causes of and effective treatments for stereotypic behavior in prosimians.

Analysis of Variance↗
PubMed1995

Definition of abnormal focused affections and exploration of their relation to abnormal stereotyped behaviors.

The relation between abnormal stereotyped behaviors and abnormal focused affections (i.e., abnormally consistent preferences for specific objects, symbols, and/or physical locations) was examined in 20 children with developmental disabilities. Results indicated that (a) all children who exhibited abnormal focused affections exhibited stereotypies; (b) abnormal focused affections could be studied reliably in individuals with developmental disabilities through the use of direct time-sampling observations, naturalistic observations, and informant reports; and (c) developmental age was significantly related to the frequency of (and the number of different) stereotyped behaviors and the frequency of nonstereotyped (i.e., developmentally appropriate) behaviors exhibited across the sample. Results also provide preliminary support for the notion of a general stereotyped behavioral repertoire in individuals with developmental disabilities.

Adolescent↗
PubMed1979

Behavioral rating scales for assessing phencyclidine-induced locomotor activity, stereotyped behavior and ataxia in rats.

Behavioral rating scales were developed for quantification of phencyclidine (PCP)-induced locomotor activity, stereotyped behavior and ataxia in rats. The dose-response relationship for PCP-induced locomotor activity was found to be an inverted U-shaped function over the first 25 min after injection while over the last 30 min of the experiment the function was highly linear. A linear dose-response relationship was found for ratings of stereotyped behavior and ataxia throughout the 90 min period of observation. The ratings of these two behaviors were found to be closely parallel. The effects of PCP on locomotor activity were found to be greatest during those intervals when stereotyped behavior and ataxia were at moderate levels. Ratings of locomotor activity may be confounded by ataxia when PCP is administered alone or in combination with other drugs.

Animals↗
PubMed2001

Stereotypic behaviors in mice selectively bred for high and low methamphetamine-induced stereotypic chewing.

RATIONALE: At high doses, methamphetamine produces repetitive stereotypic behaviors, and the degree to which this occurs is heritable. OBJECTIVES: Mice of a B6D2F2 genetic background were selectively bred for four generations for high (HMA) and low (LMA) numbers of stereotyped chewing episodes measured for 1 min at 33 min post-injection following 10 mg/kg methamphetamine (changed to 7 mg/kg for the high line and 15 mg/kg for the low line in the third selected generation to avoid ceiling and floor effects, respectively). We sought to determine whether stereotypic behaviors other than number of repetitive chewing episodes were altered by the selective breeding process. METHODS: HMA and LMA mice of the third and fourth selected generations were tested for chewing stereotypy, for a number of other stereotypic behaviors previously observed in rodents, and for several other non-stereotypic responses to methamphetamine. Testing in the third selected generation was conducted by observing behaviors on videotape following 7 mg/kg methamphetamine. In the fourth selected generation, mice were also tested in automated activity monitors following 10 mg/kg methamphetamine and in climbing chimneys following 16 mg/kg methamphetamine. Dose-response curves with doses of 1, 2, 3.5, 7, 10, and 15 mg/kg methamphetamine were constructed for the most commonly observed behaviors. RESULTS: LMA mice, which exhibited low stereotyped chewing, exhibited high stereotyped circling and climbing, and the reverse was true for these behaviors for HMA mice. For most of the other behaviors measured, there were drug effects but no differences between selected lines. CONCLUSIONS: These results suggest that these three stereotyped behaviors, chewing, circling, and climbing, at least partly share the same mechanisms, and therefore are influenced by at least some of the same genes, since animals selectively bred for low methamphetamine-induced stereotyped chewing exhibited high amounts of circling and climbing when given methamphetamine. This also suggests that the other stereotypic behaviors that we measured do not occur by the same genetically determined mechanisms as stereotypic chewing.

Alleles↗
PubMed1975

Effects of penfluridol and other drugs on apomorphine-induced stereotyped behavior in monkeys.

The effects of some drugs on apomorphine-induced stereotyped behavior were studied in male cynomolgus monkeys. Apomorphine produced the dose-dependent stereotyped behavior characterized mainly by continuous licking and biting, and repetitive movements of the hands, head and body in the monkeys. Penfluridol as well as haloperidol showed a clear antagonistic effect on the apomorphine-induced stereotyped behavior, while chlorpromazine was less antagonistic than haloperidol. The antagonistic effect of penfluridol lasted longer than that of haloperidol. Reserpine did not inhibit the apomorphine-induced stereotyped behavior though the drug elicited markedly the behavioral depression and alpha-methyl-p-tyrosine also did not block the stereotyped behavior. Nialamide did not depress the apomorphine-induced stereotyped behavior. In provoking the stereotyped behavior in monkeys, apomorphine probably acts directly on dopamine receptors in the extrapyramidal system, and penfluridol is suggested to act as a dopamine receptor blocker with a long action. The results indicate that protection against apomorphine-induced stereotyped behavior in monkeys may be a useful method for evaluating neuroleptic drugs.

Animals↗
PubMedDate not supplied

The stereotyped behavior scale: psychometric properties and norms.

The Stereotyped Behavior Scale (SBS) is an empirically developed behavior rating scale for adolescents and adults with mental retardation (Rojahn, Tassé & Sturmey, 1997). Since the original publication, one item was deleted and two items were merged, leaving 24 items. In an additional change, severity scales were added to the frequency scales. In this paper, psychometric properties and (relative) norms for the new SBS are presented. In the psychometric study, 45 adults with mental retardation from a residential facility participated. Of these, 15 were selected for high-rates or very severe forms of stereotyped behaviors, 15 for mild to moderate rates or less severe stereotypies, and 15 for the low rates or absence of stereotyped behaviors. Direct care staff familiar with the participants completed the SBS and the "Stereotypy" subscale of the Aberrant Behavior Checklist-Residential (ABC-R) (Aman, Singh, Stewart & Field, 1985). For 15 participants, two raters independently completed the SBS. In addition, 45-min direct behavior observations were conducted on 16 participants. After approximately four weeks, the instruments were completed a second time by the same raters. As for reliability, the SBS frequency and severity scale total scores yielded test-retest intraclass coefficients (ICC) of 0.93 and 0.71, ICC interrater agreement of 0.76 and 0.75, and each had an internal consistency a of 0.91. For criterion validity, the SBS frequency and severity scores correlated with the ABC-R "Stereotypy" score at 0.80 and 0.84 (Pearson r), with systematic behavior observations at 0.50 and 0.65 (Pearson r), and with the a priori classification at 0.50 and 0.65 (Spearman p). From a previous data set of 550 individuals with stereotypic behavior, normative data (percentile ranks and T-scores) were derived. The data were presented in two tables, one showing a breakdown of gender by age groups, and the second one of age groups by level of functioning.

Adult↗
PubMed1976

Acute increases by p-chlorophenylalanine of apomorphine-induced stereotyped behavior in the rat.

The stereotyped behavioral syndrome induced in the rat by apomorphine was enhanced by acute systemic administration of PCPA. This effect was dependent on the dose of PCPA and half-maximal at approximately 150 mg/kg, i.p.; it occurred within 30 min, was greatest between 1 and 5 h and had nearly disappeared by 24 h after an acute dose of PCPA. A similar effect was not found at 24 or 48 h following 3 repeated doses of PCPA of 300 mg/kg/day. This effect of PCPA was not reversed by 5-HTP or by high doses of a decarboxylase inhibitor. PCPA alone did not produce stereotyped behavior, although it produced some behavioral excitation in high doses following inhibition of monoamine oxidase. This acute behavioral effect of PCPA to potentiate apomorphine-induced stereotyped responses is unexplained. It does not seem to be due to depletion of 5-HT or to the formation of an amine as an active metabolite. We suggest that PCPA can have behavioral excitatory actions independent of its 5-HT-depleting action.

5-Hydroxytryptophan↗
PubMed2003

Structural and environmental characteristics of stereotyped behaviors.

Structural and environmental characteristics of multiple topographies of stereotypic behaviors shown by 8 individuals with developmental disabilities are described. Analysis of structural characteristics show that the parameters of stereotyped behavior (percentage of time, bout length, and bout length variability) were highly correlated. Analysis of the influence of environmental variables indicated that topographies of stereotyped behaviors were more likely to occur under conditions of low stimulation and less likely during conditions involving social contact. Individuals whose stereotyped behaviors were less influenced by environmental factors were more likely to engage in them for greater periods of time. Results suggest that an examination of individual topographies of stereotyped behaviors and their structural and environmental characteristics may provide useful insights for understanding the origins of these behaviors.

Adolescent↗