The New England journal of Medicine: editor's report, 1967-1977.
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Ordering and interpreting laboratory tests take familiarity with the concepts of normal limits, specificity, sensitivity, and prevalence. The relative importance of these test properties for clinical decisions is presented.
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Though therapeutic clinical trials are often categorized as using either "randomization" or "historical controls" as a basis for treatment evaluation, pure random assignment of treatments is rarely employed. Instead various restricted randomization designs are used. The restrictions include the balancing of treatment assignments over time and the stratification of the assignment with regard to covariates that may affect response. Restricted randomization designs for clinical trials differ from those of other experimental areas because patients arrive sequentially and a balanced design cannot be ensured. The major restricted randomization designs and arguments concerning the proper role of stratification are reviewed here. The effect of randomization restrictions on the validity of significance tests is discussed.
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A statistical power analysis of The American Journal of Physical Anthropology (Volume 44, 1976) was conducted. Twenty-five articles, which included 3,304 major significance tests, constituted the final sample. Resultant power estimates of 0.38, 0.62, and 0.81, corresponding to small, medium, and large population effects respectively, were obtained. Although the medium effect size estimate falls short of the recommended 0.80 level, the statistical power of physical anthropological research fares well relative to several of the social scientific fields of inquiry.
The current cancer literature is imprecise and confusing. This hampers the ability to draw meaningful conclusions regarding diagnosis and treatment. It is suggested that all future reporting of statistics contain the following features: (1) discussion of case selection criteria; (2) use of TNM system for case classification; (3) listing of minimal treatment details; (4) explanation for length of follow-up used; (5) standardized terms for evaluation (relating these to individual TNM classification); and (6) listing of all failures by standardized terms. It is proposed that editors of journals and organizers of meetings reject all papers that do not meet these criteria.
A descriptive statistic study about journals and pediatric articles at international level is presented. Three of the main international repetories of medical bibliography, have been used as sources, collecting a total of three hundred periodical pediatric publications. A distribution of these publications by languages, places or impression, periodicity of appearance and percent of sub-specialization is made. In relation with pediatric papers, we have studied their presence in non medical scientific journals, medical but non pediatric journals and in those of the speciality, analizing the percentage of these papers in each one of them.
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