[Immunogenecity and antigenic properties of staphylococcal toxoid and vaccine in laboratory animals. I. Staphylococcal toxoid].
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After the immunization of pregnant rats with purified adsorbed staphylococcal toxoid the antigen could be detected 2-48 hours later in the parenchymatous organs (the liver, the spleen), but not in the blood serum and the amniotic fluid. The rats immunized at an early period of pregnancy showed the presence of the antigen in their placenta and fetuses, while after the immunization at a late period of pregnancy the antigen could be only seldom detected in the placenta and practically never in the fetuses. There are grounds to believe that staphylococcal toxoid does not pass from the mother to the fetus through the completely formed placenta.
The results of the immunoleukolysis test in 699 women on the 32nd week of pregnancy are presented. Of these, 48 women were examined 1 month and 6 months after the third injection. In this test staphylococcal allergen and E. coli allergen were used. Staphylococcal toxoid was found to have desensitizing action in persons with enhanced initial allergic state. The authors conclude that the immunoleukolysis test may ensure differential approach to the immunization of pregnant women with staphylococcal toxoid.
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