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At least 19 recordsLinked to original sources

[Comparison of the concept of forensic medicine in Southeastern Asia and Central Europe].

Differences in conception of forensic medicine in the central Europe and south-eastern Asia are consisted in both legislative difference and different view of religion as well in fact, that forensic medicine is a very young subject in Vietnam and in some nearby countries that dispose of not enough professional workplaces and specialists. In this point, an intense reverse is coming about, especially owning to possibility of an abroad study of this subject in countries that have longer tradition.

Asia, Southeastern↗

Malaria in prehistoric southeastern Asia.

This paper reviews the evolutionary and natural history of malarias; it is proposed that all human malarial parasites originated from zoonotic simian plasmodiids in tropical forests of southeastern Asia, during the terminal Pleistocene or early Holocene. The modes of malarial transmission among prehistoric natives of that geographic area is reconstructed, based primarily on ecological, archeological and ethnographic evidence. Early Holocene hunters and food gatherers of southeastern Asia shared the same forest habitats as several mosquito members of the Anopheles leucosphyrus group, known to be efficient malarial vectors. These forest dwellers could have maintained endemic malaria, however at low levels due to their low population density. With the abundance and interactive roles in transmitting human malaria of the An. dirus and An. minimus mosquitos in forest fringe areas, the middle Holocene settled farmers occupying such habitats would have been subject all year round to highly endemic malaria. Generally much lower and less uniform transmission of the disease could have been found among early coastal occupants, in the presence of the less efficient An. sundaicus vector. Malaria was practically absent on lowland floodplains, extensively occupied by human populations since the first millennium BC onwards, due to lack of major vectors.

Animals↗

Mutations clustered in exon 5 of the p53 gene in primary nasopharyngeal carcinomas from southeastern Asia.

Mutations in the p53 tumor suppressor gene play an important role in the development of many common human malignancies. In nasopharyngeal carcinomas (NPC), p53 gene mutations were not detected in primary tumors, with one exception for a primary tumor displaying a p53 mutation at codon 280, whereas p53 mutations were identified in some metastatic and nude mouse-passaged NPC specimens. In the present report, 41 NPC primary tumors of the undifferentiated carcinoma nasopharyngeal type (UCNT; 21 from Hong Kong and 20 from Guangxi, southeastern China) were studied. Four point mutations that result in amino acid substitutions were identified by PCR amplification of exons 2-9 and direct DNA sequencing, combined with PCR-single-strand conformation polymorphism analysis. The 4 mutations detected were clustered within the DNA stretch from codon 175 to 177. Our data, taken together with those of others, suggest that mutation in p53 may occur in NPC at various points during tumorigenesis. Alternative mechanisms of p53 inactivation in NPC are also possible.

Animals↗

Population problems in Austronesia.

The author examines population issues facing countries in Oceania and Southeastern Asia. "Analysis is based on recently released population projections from the United Nations Population Division. There are great differences among the countries.... There are nonetheless important areas of commonality: all nations are facing the problem of raising levels of schooling in line with parents' aspirations and economic needs, all face problems of caring for a rising proportion of aged, and all have difficulties with the monitoring and control of international migration. Also, since minority groups in many countries are majority polities in neighbouring states, there is potential for establishing international dialogues aimed at relieving internal tensions." Consideration is given to the role of Australia in promoting international cooperation to deal with these issues.

Asia↗

Genetically distinct populations in an Asian soldier-producing aphid, Pseudoregma bambucicola (Homoptera: Aphididae), identified by DNA fingerprinting and molecular phylogenetic analysis.

To estimate genetic structure of a soldier-producing aphid, Pseudoregma bambucicola, samples from natural populations throughout southeastern Asia were analyzed by a DNA fingerprinting technique. We unexpectedly found that P. bambucicola comprises two geographic groups, the northern group and the southern group, which are genetically distinct from each other but morphologically almost indistinguishable. Molecular phylogenetic and statistical analyses based on mitochondrial ribosomal DNA sequences demonstrated that the northern and southern groups of P. bambucicola are not closely related but constitute distinct lineages in the genus Pseudoregma. Detailed morphological reexamination revealed that the two groups could be distinguished by the number of setae on the 8th abdominal tergite of 1st instar nymphs and soldiers. From these results, it was suggested that P. bambucicola should be divided into two species. The northern group from Japan, Taiwan, Hong Kong, and northern Vietnam retains the name P. bambucicola, whereas we suggest that the name P. carolinensis (R. Takahashi, 1941, Tenthredo 3, 208-220) should be used for the southern group from Thailand, Malay Peninsula, Java, Irian Jaya, and Micronesia. The morphological resemblance between P. bambucicola and P. carolinensis might be due to shared ancestral characters of the genus Pseudoregma.

Animals↗

Interrater reliability of the scoring of the screening test of adolescent language.

Group administrations of the Screening Test of Adolescent Language have been successful in identifying students with English-language problems among groups of university students who include many recent immigrants from southeastern Asia. However, scoring several items requires subjective judgement. Accordingly, interrater reliability was investigated by having two independent examiners score the written responses of 299 first-year medical students at two Australian universities. The examiners produced very similar distributions of total scores with means of 20.36 and 19.36 and achieved a high agreement in the categorisation of students with English problems. The Spearman rank-order correlation of 0.83 was high and statistically significant from zero.

Adolescent↗

Asian domains of four major genotypes of JC virus, Af2, B1-b, CY and SC.

JC virus (JCV) strains worldwide can be classified into various genotypes based on DNA sequence variations. To define the domains of the four major JCV genotypes in Asia, we collected urine samples at six unstudied sites: three in southeastern Asia, two in the central highlands and one in central Asia. DNA was extracted from urine samples, and used to amplify a 610-bp region of the viral genome. For each geographical site, we determined 16 to 31 sequences, from which a phylogenetic tree was constructed to unambiguously classify detected JCV isolates into distinct genotypes. From JCV genotype profiles at the sites studied here and elsewhere, the following conclusions were drawn. Although Af2 is the major genotype in Africa, this genotype also occurs in western and central Asia. B1-b mainly occurs in western and central Asia, including the central highlands. CY occurs in northeastern Asia with the southern boundary between China and southeast Asian countries. Although SC predominates in southeastern Asia, it also occurs in northern and central Asia at lower frequencies. In addition, a few minor JCV genotypes (B1-a, B2 and B3) occur at many sites. We discuss here the anthropological and medical significance of the present findings.

Adult↗

JC virus genotypes in a Taiwan aboriginal tribe (Bunun): implications for its population history.

The origin of Taiwanese aborigines remains obscure; it has been speculated that they may be from either mainland China or southeastern Asia. We used the JCV genotyping method to elucidate the origin of Bunun aborigines who now live in central mountain areas of Taiwan. We found that Bunun aborigines carried two major (B1-a2 and CY) and two minor JCV genotypes (B1-a1 and SC). This was contrasted with the JCV genotype profile in modern Taiwanese: one major (SC) and two minor genotypes (CY and B1-a1). It thus appears that B1-a2 and CY are indigenous to the Bunun tribe. B1-a2 was first identified in this study as a discrete cluster that contained only Bunun and Philippine JCV isolates and that was closely related to B1-a1, one of the three common JCV genotypes in China. CY predominates in North China, while SC predominates in South China and southeastern Asia. The present findings suggest that the Bunun tribe is an admixture of two ethnic groups, one carrying B1-a2 and the other carrying CY. In other words, it is likely that the Bunun tribe was established by two waves of immigrations from mainland Asia, predating those by southern Chinese which began in the 17th century.

Adolescent↗